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    Effect of dexmedetomidine on erythrocyte deformability during ischaemia-reperfusion injury of heart in diabetic rats
    (Comenius University, 2014) Arslan M.; Comu F.M; Kip G.; Alkan M.; Kiraz H.A.; Ozer A.; Sivgin V.
    The aim of this study is to evaluate the effect of dexmedetomidine on erythrocyte deformability during IR heart injury in diabetic rats. Methods: Eighteen Wistar Albino rats were included in the study after streptozocin (55 mg/kg) treatment for four weeks. In the Group C and DC (sham-control group), the coronary artery was not occluded or reperfused in the control rats. In the Group DIR, a branch of the left coronary artery was occluded for 30 minutes followed by two hours of reperfusion to produce IR. In the Group DIRD, a branch of the left coronary artery was occluded for 30 minutes followed by two hours of reperfusion to produce IR, and dexmedetomidine was administrated via 100 ?g/kg IP route 30 minutes before ligating the left coronary artery. Deformability measurements were performed in erythrocyte suspensions containing Htc 5 % in a PBS buffer. Results: The deformability index was signifi cantly increased in diabetic rats; however, it was similar in the Group DC and DIRD. It was signifi cantly increased in the Group DIR when compared to the Group C, DIRD and DC. The relative resistance was increased in IR models. Conclusion: Erythrocyte deformability was decreased in rats having diabetes and IR injury. This injury might lead to further problems in microcirculation. It was shown that dexmedetomidine might be useful in enhancing the adverse effects of this type of injury.
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    The effect of levosimendan on myocardial ischemia[1] reperfusion injury in streptozotocin-induced diabetic rats
    (Co-Action Publishing, 2015) Kiraz H.A.; Poyraz F.; Kip G.; Erdem Ö.; Alkan M.; Arslan M.; Çomu F.M.
    Objective: Ischemia/reperfusion (I/R) injury is an important cause of myocardial damage by means of oxidative, inflammatory, and apoptotic mechanisms. The aim of the present study was to examine the potential cardio protective effects of levosimendan in a diabetic rat model of myocardial I/R injury. Methods: A total of 18 streptozotocin-induced diabetic Wistar Albino rats (55 mg/kg) were randomly divided into three equal groups as follows: the diabetic I/R group (DIR) in which myocardial I/R was induced following left thoracotomy, by ligating the left anterior descending coronary artery for 60 min, followed by 2 h of reperfusion; the diabetic I/R levosimendan group (DIRL), which underwent I/R by the same method while taking levosimendan intraperitoneal 12 mg kg-1; and the diabetic control group (DC) which underwent sham operations without tightening of the coronary sutures. As a control group (C), six healthy age-matchedWistar Albino rats underwent sham operations similar to the DC group. Two hours after the operation, the rats were sacrificed and the myocardial tissue samples were examined by light microscopy for evidence of myonecrosis and inflammatory cell infiltration. Results: Myonecrosis findings were significantly different among groups (p = 0.008). Myonecrosis was more pronounced in the DIR group compared with the C, DC, and DIRL groups (p = 0.001, p = 0.007 and p = 0.037, respectively). Similarly, the degree of inflammatory cell infiltration showed significant difference among groups (p<0.0001). Compared with C, DC, and DIRL groups, the inflammatory cell infiltration was significantly higher among the DIR group (p<0.0001, p<0.0001, and p=0.020, respectively). Also, myocardial tissue edema was significantly different among groups (p=0.006). The light microscopic myocardial tissue edema levels were significantly higher in the DIR group than the C, DC, and DIRL groups (p=0.001, p=0.037, and p=0.014, respectively). Conclusion: Taken together, our data indicate that levosimendan may be helpful in reducing myocardial necrosis, myocardial inflammation, and myocardial tissue edema resulting from ischemia-reperfusion injury. © 2015 Hasan Ali Kiraz et al.
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    Effect of psychological status on respiratory symptoms
    (2005) Ekici A.; Oğuztürk Ö.; Ekici M.; Kurtipek E.; Akin A.; Arslan M.; Tunçkol M.
    Objective: To investigate whether psychological status affects respiratory symptom reporting and objective measures of the respiratory system. Materials and Methods: This study was performed in 1090 male gun factory workers and in 420 women exposed to biomass. The subjects were questioned using a Respiratory questionnaire. Respiratory functions were measured by portable spirometer. Psychological status was measured by HAD scale. Groups with high HAD total scores and low HAD total scores were classified by the median value. Results: In males: Chronic cough (17.6% vs. 10.7% p=0.001), chronic phlegm (13.2% vs. 8.9%, p=0.02), and probable asthma (39.5% vs. 25.5%, p=0.0001) were significantly more frequent in the group with high HAD total scores than in the group with low HAD total scores but definite asthma was not (6.2% vs. 4.6%, p=0.2). In women: Chronic cough (34.8% vs. 23.5% p=0.009), chronic phlegm (23.9% vs. 15.4%, p=0.02), and probable asthma (53.5% vs. 35.3%, p=0.0001) were significantly more frequent in the group with high HAD total scores than in the group with low HAD total scores but definite asthma was not (7.0% vs. 9.0%, p=0.4). Conclusion: Psychological status might affect the frequency of symptom reporting in respiratory questionnaires. The questionnaires and psychological status indices should be interpreted simultaneously.
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    The evaluation of effects of lornoxicam on blood flow and erythrocyte deformabilityin comparison with IV paracetamol in rats
    (2012) Arslan M.; Comu F.M.; Isik B.; Atac M.S.; Yilmaz D.
    Background: Lornoxicam and iv paracetamol are commonly preferred to be used for postoperative analgesia. Although Aspirin is a well known non-steroid anti-inflammatory drug that decreases the erythrocyte deformability, there is no study comparing lornoxicam and iv paracetamol regarding their effects on erythrocyte deformability recorded in literature. The aim of this study was to compare the effects of lornoxicam and IV paracetamol on blood perfusion and erythrocyte deformability on rats. Methods: Twenty male Wistar Albino rats were randomly divided into three groups as Lornoxicam group (Group L), IV paracetamol group (Group P), and control group (Group C). Intraperitoneal administrations were done in all groups except Group C. Liver and renal blood flows were conducted by laser Doppler and euthanasia was performed via intraabdominal blood uptake. Erythrocyte deformability was measured using a constant flow filtrometer system. Results: Lornoxicam increased the relative resistance which shows the erythrocyte deformability in rats (p<0.05). The comparison of Groups C and P revealed no statistically different results (p=0.731) while Group L revealed statistically higher results than Group C (p=0.022). No statistically significant differences were found between groups L and P (p=0.073). Liver and renal blood flow values in Group L were just numerically decreased not statistically whilst no statistically significant difference was found between the three groups. Conclusions: Lornoxicam have lead to functional disorders related to tissue perfusion as a result of both decreased blood flow and erythrocyte deformability.
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    The protective effects of dexmedetomidine on hepatic ischemia reperfusion injury
    (Comenius University, 2014) Kucuk A.; Yaylak F.; Cavunt-Bayraktar A.; Tosun M.; Arslan M.; Comu F.M.; Kavutcu M.
    Objective: The aim of this study was to evaluate the effect of dexmedetomidine (100 ?g/kg-ip) on liver ischemia and reperfusion (I/R) in rats. Methods: Twenty-four Wistar Albino rats were separated into three groups as control (C), ischemia-reperfusion injury (I/R) and dexmedetomidine group (I/R-D). Ischemia was induced with portal clampage for 45 minutes and reperfusion period was 45 minutes after declampage. Group I/R-D was received dexmedetomidine 100 ?g/ kg i.p. 30 min before portal clampage. Thiobarbutiric Acid-Reactive Substances (TBARS), glutathioneS-transferase (GST), superoxide dismutase (SOD), Catalase (CAT), and Paraoxonase 1 (PON-1) were investigated in blood samples. Also HSP60 and p53-positive hepatocytes were counted under ImageJ image analysis program. Results: All parameters, except GST levels, were significant between the groups (p < 0.05). Although HSP60 expression was significantly increased between I/R, I/R-D and C groups there were no significant differences between I/R-D and C (p = 0.443). On the other hand, p53 expression was also significantly increased between I/R, I/R-D and C groups At the same time, there were no significant differences between I/R-D and C groups (p = 0.354). Conclusion: All the results suggest that dexmedetomidine has beneficial effects on liver ischemia/reperfusion stress.
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    Serum resistin and adiponectin levels in women with polycystic ovary syndrome
    (2009) Yilmaz M.; Bukan N.; Demirc H.; Öztürk Ç.; Kan E.; Ayvaz G.; Arslan M.
    Aim. This study was performed to compare the serum levels of resistin and adiponectin in women with polycystic ovary syndrome (PCOS) and normal controls. Materials and methods. Seventy-six patients (36 obese, 40 non-obese) with PCOS and 42 healthy subjects were included in the study. Serum levels of resistin, adiponectin, follicle-stimulating hormone, luteinising hormone, dehydroepiandrosterone sulfate (DHEA-S), 17-hydroxy progesterone, free testosterone, androstenedione, glucose, insulin and lipid parameters were measured. Insulin resistance and carbohydrate metabolism were evaluated by using the homeostasis model (HOMA) and the area under the insulin curve (AUCI). Results. Plasma resistin levels, HOMA-IR and AUCI were significantly higher and adiponectin level was lower in women with PCOS than those in healthy women. Plasma resistin levels were similar among obese and non-obese women with PCOS. No correlation was observed between resistin, body mass index (BMI), HOMA-IR, AUCI, insulin, lipid parameters and serum androgen levels. In obese PCOS patients, adiponectin levels were lower than in the lean PCOS patients. A negative correlation was observed among adiponectin, HOMA-IR, AUCI, BMI, testosterone, DHEAS, total-cholesterol, LDL-cholesterol and lipoprotein (a) levels. Conclusion. These results suggest that the serum adiponectin level may be involved in the pathogenesis of PCOS. But resistin levels were independently associated with insulin resistance and BMI in PCOS patients. Nevertheless, wider-scale trials are required to be performed on this subject.