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Öğe Development and Assessment of a Coping Scale for Infertile Women in Turkey(Womens Health & Action Research Centre, 2018) Karaca, Aysel; Unsal, Gul; Asik, Elif; Keser, Ilkay; Ankarali, Handan; Merih, Yeliz DoganInfertile women feel more psychological stress and pressure than their husbands, and the prevalence of anxiety and depression among them are higher. This study aimed to develop a culture-specific measurement tool to identify the strategies of infertile women in dealing with infertility-related problems. This was a scale development study. This study was carried out in three different fertility centers in the three largest cities in Turkey. The data were collected using personal information form and through the application of a Coping Scale for Infertile Women (CSIW) protocol. Ways of Coping with Stress Inventory. Cronbach's alpha, Intraclass Correlation Coefficient and Spearman` s Rank correlation analyses were used to determine the reliability of the scale. The results of explanatory factor analysis and a factor structure of the Coping Scale for Infertile Women, comprising 50 items, were examined, and the data were determined to be suitable to perform factor analysis. The internal consistency of the scale was found to be 0.880. The number of factors in the scale was 10, and the internal consistency of the factors was 0.720. The results showed that the CSIW had good reliability and validity.Öğe An evaluation of a psychoeducation programme for emotion identification and expression in individuals diagnosed with schizophrenia(WILEY, 2020) Asik, Elif; Unsal, GulThe inability of individuals diagnosed with schizophrenia to recognize facial expressions is an important issue that has an impact on social functioning. This study was conducted to determine the effects of a psychoeducation programme for emotion identification and expression in those diagnosed with schizophrenia on their ability to identify and discriminate between emotions and social functionality. This quasi-experimental study (pretest-post-test, with control group) comprised an intervention (21) and a control (21) group conducted with individuals diagnosed with schizophrenia. A 10-week psychoeducation programme was offered to the intervention group. Measuring instruments were administered to the groups before the intervention, after the intervention, and 3 months after that. The measuring instruments consisted of a personal information form, the Facial Emotion Identification Test, Facial Emotion Discrimination Test, and Personal and Social Performance Scale. The data were analysed using the 'two-way repeated measures analysis of variance'. The TREND method was used for reporting. In the first measurements taken after the psychoeducation programme, a significant difference was found between the two groups in terms of their 'Facial Emotion Identification Test' and 'Personal and Social Performance Scale' mean scores. In the measurements taken 3 months after the psychoeducation programme, this difference had disappeared. The psychoeducation programme is an effective programme that makes recognition of facially expressed emotions possible and increases the social functioning of patients.Öğe Modified gold-based siRNA nanotherapeutics for targeted therapy of triple-negative breast cancer(Future Medicine Ltd, 2017) Shahbazi, Reza; Asik, Elif; Kahraman, Nermin; Turk, Mustafa; Ozpolat, Bulent; Ulubayram, KezbanAim: In this study, we aimed to therapeutically target eukaryotic elongation factor 2 kinase (eEF-2K) in an in vivo triple-negative breast cancer (TNBC) tumor model. Materials & methods: We synthesized a highly monodisperse nanoformulation using polyethylenimine-modified gold nanoparticles (AuNP-PEI) as siRNA delivery vehicle and evaluated gene downregulation. Results: We found that AuNP-PEI/eEF-2K nanoformulation was highly effective for in vitro and in vivo gene downregulation and showed remarkable antitumor efficacy that was associated with eEF-2K knockdown, inhibition of Src and MAPK-ERK signaling pathways in a TNBC orthotopic tumor model. Conclusion: Our study suggests that eEF-2K plays an important role in TNBC tumorigenesis and its inhibition by AuNP-PEI/eEF-2K siRNA-based nanotherapeutics may be a potential therapeutic strategy for TNBC.Öğe Nursing Practices Addressing Metabolic Syndrome Risk in Patients using Antipsychotic Drugs(Aves Press Ltd, 2016) Asik, Elif; Albayrak, Sevil; Erdogan, NerminObjective: This study was conducted among psychiatric nurses from the provinces of Ankara, Bolu, and Kirikkale for the purpose of determining which practices were undertaken against the risk of developing MetS among patients taking antipsychotic drugs. Methods: This study was a descriptive research. The legally required permissions for the studies were obtained from the three provinces. Ethical Board Permission was obtained from a university. The study comprised 145 persons, and 78.6% of the study population (n=114) participated in the research voluntarily. The data collection form was prepared by the researchers based on the literature and comprised 24 questions. The data were based on self-reporting. Results: Regarding the equipment available at the clinics for use in evaluating patients for MetS, 98.2% of the nurses said they had scales, 87.7% reported height measuring tools, 86.0% reported waist measuring tape, and all of the nurses reported the availability of a sphygmomanometer. Of the nurses, 36.8% said that they frequently encountered patients carrying MetS risk. Of the nurses, 55.8% however reported that they did not counsel patients to check their blood sugar and blood lipids after their discharge from the hospital, 42.5% said they did not advise patients to check their blood pressure after discharge, 42.5% said they did not educate their patients to regularly keep track of their waist measurements and weight after discharge, and 60.2% stated that they did not always tell patients that they should check their body mass index reading. Conclusion: Nurses usually have available materials to follow up on patients who are at a risk of developing MetS. However, approximately half of the nurses revealed that they did not inform patients during their discharge or at their follow-ups about the monitoring procedures that are necessary in terms of MetS risk.
