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    Öğe
    Asemptomatik Nörosifiliz ile İlişkili Optik Nörit Olgusu
    (2022) Atalay, Enes; Gökçınar, Nesrin; Yumusak, Erhan; Örnek, Nurgül; Asal, Neşe
    Bu yazıda, optik nörit ile başvuran bir hastada, sifiliz tanı ve tedavi yaklaşımını sunmayı amaçlıyoruz. Kırk dört yaşındaki erkek hasta, sol gözde görme kaybı ile başvurdu. Tek taraflı vitrit, optik disk ödemi ve görme alanı skotomu vardı. Zührevi hastalıkları araştırma laboratuvarı ve floresan treponemal antikor absorbsiyon immünglobulin G sifiliz testleri pozitifti. Sifilizin dermatolojik veya başka bir sistemik bulgusu yoktu. Ancak kraniyal manyetik rezonans görüntülemesinde periventriküler ve subkortikal derin beyaz cevherde multipl plaklar mevcuttu. Hasta, sifilitik optik nörit ve nörosifiliz tanısı aldı. Nörosifiliz bu olguda, göz bulguları dışında asemptomatikti. İntravenöz penisilin G, oral doksisiklin ve oral metilprednizolon tedavisi uygulandı. Sifiliz, büyük taklitçi olarak bilinmektedir. Özellikle net tıbbi öykünün elde edilemediği durumlarda, inflamatuar göz hastalıklarının ayırıcı tanısında düşünülmelidir.
  • [ X ]
    Öğe
    The role of oxidative damage in cataract etiopathogenesis
    (Sage Publications Ltd, 2023) Atalay, Enes; Ogurel, Tevfik; Derici, Mehmet Kursat
    Background:Cataract usually occurs due to age and diabetes, but the mechanisms of cataract formation have not yet been fully elucidated. In this study, the relationship between cataract and oxidative stress was evaluated by examining the aqueous humor reflecting lens metabolism. Objective:In this study, the effect of oxidative stress on the etiopathogenesis of cataract was investigated through the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and arylesterase (ARE) levels in aqueous humor samples of patients with cataract. Design:A prospective cohort study. Methods:This study was conducted on patients who were scheduled for cataract surgery between June 2020 and March 2021. The patients were divided into four groups according to their cataract density as grades 1, 2, 3, and 4. TOS, TAS, and ARE levels of aqueous humor samples were measured spectrophotometrically, and comparisons were made between groups. Results:A total of 100 eyes of 100 patients were included in this study. TAS levels were found significantly higher in the grade 2 group compared with the grade 4 group (p = 0.006). In addition, a significant negative correlation was present between cataract grade and TAS level (r = -0.237; p = 0.018). There was no significant difference between diabetic and nondiabetic patients in terms of TAS, TOS, OSI, and ARE levels. Conclusion:The aqueous humor of patients with a high degree of cataract is characterized by low antioxidant capacity. Decreased antioxidant capacity has a role in cataract formation and progression.