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    Health-related quality of life and parental depression in children with pulmonary arterial hypertension
    (Wiley, 2022) Canbeyli, Fatma H.; Atasayan, Vildan; Tokgoz, Semiha; Tunaoglu, Fatma S.; Oguz, Ayse D.; Celik, Bulent; Kula, Serdar
    Background Impaired health-related quality of life (HRQoL) is a common problem in pulmonary arterial hypertension (PAH), but there is limited data on HRQoL in children with PAH. We aimed to investigate the QoL, determine the potential risk factors for poor HRQoL in children with PAH, and assess the depression and anxiety of their families. Methods We performed a prospective cross-sectional study of children with PAH, healthy peers, and their parents. HRQoL was measured by the self-reported and age-adapted KINDL questionnaire. Beck Depression Inventory (BDI) and hospital anxiety and depression scale (HADS) were used to assess the depression and anxiety of parents. Results Children with PAH had statistically lower total HRQoL scores than healthy peers (p < 0.001). There was no correlation between HRQoL and duration of disease, World Health Organization functional class, pro-B-type natriuretic peptide, 6-min walk test, and combined or single treatment. BDI and HADS scores were significantly higher in the parents of patients (p < 0.001, p = 0.023, p < 0.001, respectively). There was a negative correlation between HRQoL and BDI in patients (p = 0.016), while there was no significant correlation between HRQoL and HADS (p > 0.05). Conclusion We demonstrated impairment of HRQoL of children with PAH. In addition, there was a correlation between the depression of the families and the QoL of the children.
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    Prognostic value of oxygen saturation and heart rate during a six-minute walk test in pediatric pulmonary hypertension
    (Tubitak Scientific & Technological Research Council Turkey, 2021) Atasayan, Vildan; Canbeyli, Fatma; Tunaoglu, Fatma Sedef; Oğuz, Ayşe Deniz; Çelik, Bülent; Kula, Serdar
    Background/aim: Th evaluate the pre and post-treatment heart rate and oxygen (O-2) saturation values measured before, during and after 6MWT in children who received PAH-specific treatment and to determine the effect of these variables on prognosis. Materials and methods: This retrospective study included 29 patients who were diagnosed as PAH and treated. The transcutaneous O-2 saturation and heart rate levels were recorded before the test: baseline (Sat0, HR0), at the end of the test: exercise (Sal1, HR1) and 5 min after the test: recovery (Sat2, HR2). The increase in heart rate was defined as HR1-HR0 and the decrease in saturation as Sat0-Sat1. The results obtained before and after the PAH-specific treatment were analyzed and their effect on survival was assessed. Results: Fifteen of 29 patients were female (51.7%). The mean age was 127.2 +/- 44.8 months and the median follow-up time was 60 (12-156) months. Only pre-treatment HR1 was found associated with survival. The mean HR1 value of survivors was 122.8 +/- 18.4 and that of deceased 94.3 +/- 19.1 (p = 0.03). Post-treatment 6MWT was associated with survival. It was 453.3 +/- 96.5 in for survivors and 250 +/- 135.2 m for deceased (p = 0.02). Conclusion: Post-treatment 6MWT, FC and proBNP had prognostic value in pediatric patients with PAH. The decrease in saturation and increase in heart rate were not found to have a prognostic value. Pre-treatment HR1 was associated with survival. Identification of these prognostic factors at the beginning and throughout the treatment may be a guide for detecting the severity of the disease and follow-up.