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    Comparison and evaluation of CA 15-3, c-erbB-2, ER and PR tumor markers in pleural fluid cytology from metastatic breast cancer as a diagnostic tool
    (2009) Oğuztüzün, Serpil; Atay, Meral; Kiliç, Murat; ÖZhavzali, Müzeyyen; Atay, Ziya
    This study has been conducted to determine the diagnostic value of CA 15-3 in detecting metastatic breast carcinoma in pleural fluid. The material studied consisted of 115 malignant pleural effusions from invasive breast cancer patients. Expressions of CA 15-3, c-erbB-2, estrogen receptor (ER) and progesterone receptor (PR) were studied using immunocytochemistry. Of the cases studied, 115 were evaluated for CA 15-3, 70 for c-erbB-2, 100 for ER and 97 for PR. The 94% of the breast cancer cases studied showed a positive reaction with CA 15-3, while 31% for c-erbB-2, 20% for ER and 9% for PR were positive (p<0.01). The sensitivities of CA 15-3, c-erbB-2, ER and PR were 94%, 31%, 20% and 9%, respectively, for metastatic breast carcinoma. Our results indicate that CA 15-3 has the highest sensitivity for diagnosing malignant breast carcinomas in pleural fluids.
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    The usefulness of GST lsoenzymes as markers of malignancy in urinary cytology
    (2010) Oğuztüzün, Serpil; Kılıç, Murat; Çakır, Ebru; Atay, Ziya
    This study investigated the usefulness of GST lsoenzymes immunostaining as an early marker of malignancy in urinary cytology. They are also correlated with cytopathology diagnosis. In this study, the slides from 22 patients of benign urinary cytology who have benign urinary diseases and 6 patients who have clinical diagnosis of bladder carcinoma were observed. The cytomorphological characteristics and the immunocytochemical expression of GST alpha (GSTA), pi (GSTP), mu (GSTM4), theta (GSTT 1) isoen2ymes were examined. Immunohistochemical examinations showed that the urothelial cancer cells had stronger staining intensity than the benign cells in 5 (83%) cases for GSTA, 5 (%83) cases for GSTP, 1(%17) case for GSTM4 and 4 (%67) cases for GSTT1. The atypical cells had stronger staining intensity than the benign cells in 10 (%45) cases for GSTA, 16 (%73) cases for GSTP, 12 (%55) cases for GSTM4 and 13(%59) cases for GSTT1. There was no significant difference in GSTA, GSTM4, GSTT1, GSTP expressions for benign, atypical and malign cells (p>0.05). In conclusion, GST lsoenzymes were not found to be markers of malignancy in urinary cytology. © IDOSI Publications, 2010.