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    Comparison and evaluation of CA 15-3, c-erbB-2, ER and PR tumor markers in pleural fluid cytology from metastatic breast cancer as a diagnostic tool
    (2009) Oğuztüzün, Serpil; Atay, Meral; Kiliç, Murat; ÖZhavzali, Müzeyyen; Atay, Ziya
    This study has been conducted to determine the diagnostic value of CA 15-3 in detecting metastatic breast carcinoma in pleural fluid. The material studied consisted of 115 malignant pleural effusions from invasive breast cancer patients. Expressions of CA 15-3, c-erbB-2, estrogen receptor (ER) and progesterone receptor (PR) were studied using immunocytochemistry. Of the cases studied, 115 were evaluated for CA 15-3, 70 for c-erbB-2, 100 for ER and 97 for PR. The 94% of the breast cancer cases studied showed a positive reaction with CA 15-3, while 31% for c-erbB-2, 20% for ER and 9% for PR were positive (p<0.01). The sensitivities of CA 15-3, c-erbB-2, ER and PR were 94%, 31%, 20% and 9%, respectively, for metastatic breast carcinoma. Our results indicate that CA 15-3 has the highest sensitivity for diagnosing malignant breast carcinomas in pleural fluids.
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    Thyroid transcription factor-1, cytokeratin 7 and cytokeratin 8 for differentiating primary and metastatic lung adenocarcinoma
    (2010) Oğuztüzün, Serpil; Kılıç, Murat ; Tandoğan, Nisa ; Öztürk, Latif ; Atay, Ziya
    Adenocarcinomas are the most common cause of malignancy in pleura fluids. Usual primary sites include the lung, breast, gastrointestinal tract and genitourinary tracts. Predicting the site of origin of an adenocarcinoma is difficult due to overlapping morphologic characteristics. Thyroid transcription factor-1 (TTF-1), Cytokeratin7 (CK7) and Cytokeratin8 (CK8) were investigated to differentiate the primary and metastatic lung adenocarcinoma in 14 pleura fluid samples. There was a significant difference between TTF-1, CK 7 and CK 8 expressions in primary lung adenocarcinomas (P=0.028; Chi-squared test) and in metastatic lung adenocarcinomas (P=0.004; Chi-squared test). The sensitivity of TTF-1, CK7 and CK8 as a marker for primary lung adenocarcinomas were 0, 87 and 57%, respectively. Moreover, the sensitivity of TTF-1, CK7 and CK8 as a marker for metastatic lung adenocarcinomas were 16, 86 and 75%, respectively. Overall results for primary lung adenocarcinomas demonstrated CK8 reactivity in 4 (57%) of 7 cases. Nine metastatic lung adenocarcinoma samples (75%) were positive for CK8. TTF-1 was expressed in 16% of metastatic lung adenocarcinomas, but negative TTF-1 staining was observed in all primary lung adenocarcinoma cases. It was concluded that these results confirmed that the method of TTF-1, CK7 and CK8 immunohistochemistry is not sensitive enough for the differential diagnosis of primary and metastatic lung adenocarcinomas. © IDOSI Publications, 2010.
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    The usefulness of GST lsoenzymes as markers of malignancy in urinary cytology
    (2010) Oğuztüzün, Serpil; Kılıç, Murat; Çakır, Ebru; Atay, Ziya
    This study investigated the usefulness of GST lsoenzymes immunostaining as an early marker of malignancy in urinary cytology. They are also correlated with cytopathology diagnosis. In this study, the slides from 22 patients of benign urinary cytology who have benign urinary diseases and 6 patients who have clinical diagnosis of bladder carcinoma were observed. The cytomorphological characteristics and the immunocytochemical expression of GST alpha (GSTA), pi (GSTP), mu (GSTM4), theta (GSTT 1) isoen2ymes were examined. Immunohistochemical examinations showed that the urothelial cancer cells had stronger staining intensity than the benign cells in 5 (83%) cases for GSTA, 5 (%83) cases for GSTP, 1(%17) case for GSTM4 and 4 (%67) cases for GSTT1. The atypical cells had stronger staining intensity than the benign cells in 10 (%45) cases for GSTA, 16 (%73) cases for GSTP, 12 (%55) cases for GSTM4 and 13(%59) cases for GSTT1. There was no significant difference in GSTA, GSTM4, GSTT1, GSTP expressions for benign, atypical and malign cells (p>0.05). In conclusion, GST lsoenzymes were not found to be markers of malignancy in urinary cytology. © IDOSI Publications, 2010.