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Öğe Comparison of American and European Guidelines for the Management of Patients With Valvular Heart Disease(Elsevier Inc, 2023) Inanc, Ibrahim Halil; Cilingiroglu, Mehmet; Iliescu, Cezar; NInios, Vlasis; Matar, Fadi; Ates, Ismail; Toutouzas, KonstantinosThis review compares the recommendations of the recent 2020 American College of Cardiology (ACC)/American Heart Association (AHA) and 2021 European Society of Cardiology (ESC)/European Association for CardioThoracic Surgery (EACTS) guidelines on the management of patients with valvular heart disease (VHD). ACC/ AHA and ESC/EACTS guidelines are both the updated versions of previous 2017 documents. Both guidelines fundamentally agree on the extended indications of percutaneous valve interventions, the optimal use of imaging modalities other than 2D echocardiography, the importance of a multidisciplinary Heart Team as well as active patient participation in clinical decision making, more widespread use of NOACs and earlier intervention with lower left ventricular dilatation thresholds to decrease long-term mortality. The differences between the guidelines are mainly related to the classification of the severity of valve pathologies and frequency of follow-up, level of recommendations of valve intervention indications in special patient groups such as frail patients and the left ventricular diameter and ejection fraction thresholds for intervention. (c) 2022 Elsevier Inc. All rights reserved.Öğe Effectiveness and Safety of Same-Day Discharge After Left Atrial Appendage Closure Using Moderate Conscious Sedation: One-Year Follow-Up Outcomes(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe EMCAPT Study: Effect of MitraClip Treatment on the Mitral Annulus and Left Atrial Appendage by Transesophageal Echocardiography(Elsevier Science Inc, 2023) Ates, Ismail; Inanc, Ibrahim Halil; Mutlu, Deniz; Polat, Fuat; Kaya, Zeynettin; Arslan, Gamze Yeter; Dogru, Mehmet[Abstract No tAvailable]Öğe EMCAPT study: the effect of MitraClip treatment on the mitral annulus and left atrial appendage evaluation by transoesophageal echocardiography(Termedia Publishing House Ltd, 2023) Polat, Fuat; Inanc, Ibrahim Halil; Dogru, Mehmet; Kadri, Zeina; Dindar, Ismet; Ates, IsmailIntroduction: Data on the change in mitral valve annulus diameter (MAD), and left atrial appendage (LAA) structure and function after transcatheter edge-to-edge repair (TEER) of the mitral valve in patients with secondary mitral regurgitation (MR) are lacking.Aim: To evaluate the change in these parameters just after the clip insertion and its relationship with prognosis in the long term.Material and methods: A total of 50 patients (age: 71.5 +/- 11.3 years, 70% male) with moderate-to-severe or severe MR were included in the study. Transthoracic (TTE) and transoesophageal echocardiography (TEE) were performed before and after the pro-cedure. Prognostic data were recorded with post-procedure telephone calls and follow-up visits.Results: TEE performed during the procedure showed that LAA contraction and filling velocity significantly increased (p < 0.001 for all). Systolic pulmonary artery pressure (SPAP), MAD, and LAA landing zone dimension significantly decreased (p < 0.001 for all). There was only a significant correlation between the MAD before clip placement and the MAD change after clip placement (r = 0.6, p < 0.001). During a mean follow-up period of 10.5 +/- 8.9 months, no significant correlation was found between MAD change, LAA contraction and filling velocity change, and LAA landing zone dimension change and rehospitalization, stroke, mortality, and composite outcome.Conclusions: The contraction and filling velocity of LAA, SPAP, MAD, and LAA landing zone dimension changed significantly im-mediately after the MitraClip procedure. Although these parameters are not related to composite outcome in our study, MAD, LAA diameter, and velocity need to be compared between successful and unsuccessful procedures to predict their clinical relevance.Öğe Feasibility of Same-Day Discharge Approach After Transcatheter Mitral Valve Repair Procedures: One-Year Follow-Up Outcomes(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Open Radial Artery (ORAS) Study(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Open Radial Artery Study(Excerpta Medica Inc-Elsevier Science Inc, 2024) Inanc, Ibrahim H.; Mutlu, Deniz; Efe, Zeynep N.; Kulaksizoglu, Sibel; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, IsmailRadial artery occlusion (RAO) has been the most common postprocedural complication of transradial artery access. The optimal method of prevention of RAO is still lacking. In our study, we aimed to evaluate the effect of patent hemostasis on early (24 hours) and late (2 weeks) RAO prevention. The Open Radial Artery Study was a single-arm, prospective, and multicenter study. The primary end points were early and late RAO at the vascular access site after transradial coronary procedures. Secondary end points were access site hematoma, pseudoaneurysm formation, arteriovenous fistula, and nerve injury. A total of 2,181 patients were analyzed (67% male, mean age 68 years). The mean interventional duration and hemostatic times were 75.6 +/- 55.6 and 60 +/- 5.6 minutes, respectively. Radial artery spasm occurred in 10% of patients (n = 218). Catheter kinking, radial artery rup-ture, or dissection were not observed during the procedure. RAO, hematoma, pseudoa-neurysm, arteriovenous fistula, or nerve damage was not observed in any of the patients in the early or late period. In patients who undergo coronary diagnostic or interventional procedures through transradial artery access, the patent hemostasis method seems a criti-cal step in the prevention of early and late RAO. (c) 2023 Elsevier Inc. All rights reserved. (Am J Cardiol 2024;211:130-136)Öğe Transcatheter mitral valve repair in a liver transplant candidate(Wiley, 2022) Ates, Ismail; Mutlu, Deniz; Inanc, Ibrahim Halil; Marmagkiolis, Konstantinos; Iliescu, Cezar A.; Kilic, Ismail Dogu; Cilingiroglu, MehmetUntreated severe mitral regurgitation (MR) is associated with poor outcomes due to the adverse consequences of long-standing volume overload on the left ventricle and left atrium, which leads to pulmonary hypertension and right-sided heart failure. Early intervention results in favorable long-term outcomes making appropriate timing of intervention very critical. We present a 53-year-old male with severe symptomatic MR and right sided-heart failure which progressed to cardiac cirrhosis necessitating enrollment to the liver transplant list. Transcatheter mitral valve repair (TMVR) using MitraClip implantation resulted in impressive clinical improvement and resolution of cirrhosis. Eventually, the patient was taken off the transplant list. Treatment of severe MR may lead to improvements in congestive hepatopathy.Öğe Use of IVOCT for Assessment of the Lesion Characteristics as Well as Evaluation of Vascular Healing Effects of Different Technologies in PAD Patients(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Use of SAFARI 2 as Workhorse Wire for Left-Sided Structural Heart Interventions(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Rollefson, William; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc[Abstract No tAvailable]Öğe Use of SAFARI 2n° as workhorse wire for left-sided structural heart interventions(Elsevier Inc, 2024) Inanc, Ibrahim H.; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Cilingiroglu, MehmetBackground: With the advances in percutaneous treatment technologies, the left atrial appendage occlusion (LAAO) and the transcatheter mitral valve repair using MitraClip (TMVR) are increasingly being performed today. The SAFARI 2n degrees guidewire is primarily used during transcatheter aortic valve implantation (TAVI), our group has also been using it during MitraClip and LAAO procedures. Our clinical study aimed to share our data on the safety and effectiveness for the use of the SAFARI 2n degrees guidewire during MitraClip or LAAO procedures. Methods: This study included a total of 1730 patients (948 patients of MitraClip and 782 of LAAO). It was designed as single arm, retrospective, and multicenter between July 2016 and August 2022. SAFARI 2n degrees guidewire was used exclusively during all the procedures. Results: A total of 1730 patients (male 55.8 %) were included in the study. There was no guidewire-related complications, stroke/transient ischemic attack, bleeding (minor/major/life-threatening), need for cardiac surgery, pneumonia, and vascular dissection/rupture in patients undergoing LAAO. There were 2 device-related pericardial effusions without tamponade. No stroke/transient ischemic attack, bleeding (minor/major/life-threatening), mortality, need for cardiac surgery, pneumonia, guidewire-related complication, pericardial effusion, vascular dissection/rupture, or clip embolization was observed in patients undergoing MitraClip. Conclusions: By taking advantage of its pre-shaped structure, the SAFARI 2n degrees guidewire seems to offer a reliable and safe device delivery for both MitraClip and LAAO procedures as a regular work horse wire. Our results should be confirmed by larger randomized or prospective trials.