Yazar "Ayaslioglu, E" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Evidence of chronic Chlamydia pneumoniae infection in patients with Behcet's disease(Informa Healthcare, 2004) Ayaslioglu, E; Duzgun, N; Erkek, E; Inal, ABehcet's disease is a chronic vasculitis of unknown aetiology. Particular viral and bacterial pathogens have long been suspected of playing a role in the pathogenesis of the disease. Chlamydia pneumoniae is an intracellular bacterium capable of causing chronic infections. Some reports have suggested that the microorganism might be involved in the pathogenesis of vasculitis. The purpose of the present study was to investigate a possible correlation between C. pneumoniae infection and Behcet's disease. For this purpose, 90 consecutive patients with Behcet's disease and 50 healthy controls were enrolled. Immunoglobulin A (IgA) and IgG antibodies to C. pneumoniae were determined by 2 different techniques, namely indirect fluorescent antibody assay (IFA) and enzyme linked immunosorbent assay (ELISA). IgA antibodies to C. pneumoniae were detected in 17 (18.9%) patients with Behcet's disease and in 1 (2%) healthy control by IFA. By ELISA 27 patients (30.0%) and 6 controls (12.0%) had C. pneumoniae IgA. A significant difference was observed for IgA seropositivity between the 2 groups. Although IgG seropositivity between the 2 groups did not differ significantly, the number of individuals with IgG titres of greater than or equal to 1: 1000 was significantly higher in the patient group (43.1%) compared with the control group (13.9%). These finding provide serological evidence of chronic C. pneumoniae infection in association with Behcet's disease.Öğe Plasma thrombomodulin levels in patients with Behcet's disease(Springer-Verlag, 2003) Duzgun, N; Ayaslioglu, E; Tutkak, H; Sahin, M; Aydintug, O; Olmez, UThe plasma levels of thrombomodulin in 54 patients with Behcet's disease (BD) and 20 healthy control subjects were studied. The mean thrombomodulin (TM) level was significantly higher in active BD patients than in inactive patients and healthy controls (P<0.001 and <0.01, respectively). Plasma TM levels did not show a significant relation with clinical manifestations. Increased plasma TM levels are associated with active disease and may reflect the presence of endothelial cell activation and/or injury.Öğe Serum soluble CD30 levels in Behcet's disease(Clinical & Exper Rheumatology, 2004) Düzgün, N; Ayaslioglu, E; Tutkak, HBehcet's disease is associated with the inflammatory response. Several reports indicate the presence of primarily CD4+ T cells of the Th1 subtype in the inflammation process of the disease. Serum soluble CD30 (sCD30) is reported to be released from CD4+ Th2 type cells and has been suggested to be a marker of Th2 activity In this study, serum sCD30 levels were measured in active and inactive patients with Behcet's disease, healthy controls and a group of patients with rheumatoid arthritis, typical Th1 disorder using enzyme immunoassay kit. Mean sCD30 value of 54 active patients were found significantly higher than in those of 17 inactive patients (p = 0.027), 20 healthy controls (p = 0.040) and 25 patients with rheumatoid arthritis (p < 0.001). There was a significant correlation between increased sCD30 levels and clinical activity index in active patients with Behcet's disease. High serum levels of sCD30 may reflect the activation of CD4+ T cells or a subset of them in active BD patients. In addition. to serum sCD30 levels, measurements of the Th2 cytokines may be a helpful tool for the evaluation of Th2 activity in Behcet's disease.Öğe Tetanus antitoxin Seroprevalence in patients with Behget's disease(Informa Healthcare, 2003) Ayaslioglu, E; Erkek, E; Kilic, D; Kaygusuz, S; Karaca, F; Duzgun, NAnti-tetanus antibody status was evaluated by enzyme-linked immunosorbent assay in 82 patients with Behcet's disease and 79 healthy individuals. 76 patients with Behcet's disease (92.7%) and 74 healthy controls (93.7%) had protective antibody titres against tetanus, with geometric mean levels of 1.0194+/-1.2755 and 1.3899+/-1.6533 IU/ml, respectively. The difference between the 2 groups was not statistically significant. There was a significant inverse correlation between antitoxin titres and age in patient and control groups. These findings imply that patients with Behcet's disease have intact overall immunity against tetanus.
