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Öğe CA-125 in the Diagnosis of Pulmonary Tuberculosis(Natl Inst Infectious Diseases, 2009) Ayaslioglu, Ergin…Öğe A Case of Brucellosis Presenting With Widespread Maculopapular Rash(Lippincott Williams & Wilkins, 2009) Ayaslioglu, Ergin; Kocak, Mukadder; Bozdogan, OnderHuman brucellosis is a multisystemic infectious disease with a broad spectrum of clinical manifestations. Severe complications involving musculoskeletal, nervous, genitourinary, and cardiovascular systems may be encountered during the course of the disease; however, cutaneous complications have been reported rarely. We report a patient with brucellosis in whom the main presenting clinical feature was a maculopapular rash and fever. He was initially diagnosed as brucellosis based on the standard tube agglutination test and blood culture positivity. Histopathologic examination of these maculopapular lesions showed perivascular and periadnexal inflammation with loose granuloma formation including giant cells. We emphasize that brucellosis is an infectious disease that should always be kept in mind in the differential diagnosis of a patient with rash and fever, especially in endemic areas.Öğe Multiple-Locus Variable-Number Tandem-Repeat Analysis Genotyping of Human Brucella Isolates from Turkey(Amer Soc Microbiology, 2011) Kilic, Selcuk; Ivanov, Ivan N.; Durmaz, Riza; Bayraktar, Mehmet Refik; Ayaslioglu, Ergin; Uyanik, M. Hamidullah; Kantardjiev, Todor V.A multiple-locus variable-number tandem-repeat analysis (MLVA) was applied to investigate the epidemiological relationship and genetic diversity among 162 human Brucella isolates collected from all geographic regions of Turkey in an 8-year period (2001 to 2008). The isolates were genotyped by using an MLVA assay developed in Orsay, France (MLVA-16(Orsay)) including eight minisatellite (panel 1) and eight microsatellite (panel 2, subdivided into 2A and 2B) markers. Panels 1 and 2A distinguish 14 genotypes; two of these represented 85% of the strains. Panel 2B displayed a very high discriminatory power. Three loci from panel 2B had diversity index values higher than 0.74. MLVA-16(Orsay) yielded 105 genotypes; 73 were represented by a unique isolate, and 32 included two to eight isolates. The isolates from different patients within the same outbreak or from the same patient before first-line therapy and after relapse showed identical genotypes. A number of MLVA genotypes appeared to be partially restricted to some geographic areas and displayed no annual variation, possibly reflecting persistence of genotypes in certain areas for a time span of at least a decade. This study, representing the first molecular typing results of human Brucella isolates from Turkey, indicated that Turkish human Brucella melitensis isolates were most closely related to the neighboring countries' isolates included in the East Mediterranean group.Öğe Nicolau's syndrome in a newborn caused by triple DTP (diphtheria-tetanus-pertussis) vaccination(2006) Erkek, Emel; Tuncez, Fatma; Şanlı, Cihat; Duman D.; Kurtipek, Gülcan S.; Bagcı, Yeter; Ayaslioglu, Ergin[No abstract available]Öğe Reliability of VITEK (R) 2 System for Identification of Yeasts: An Isolate of Candida parapsilosis Incorrectly Identified as Cryptococcus neoformans(Aves, 2017) Kacmaz, Birgul; Gul, Serdar; Karabicak, Nilgun; Ayaslioglu, Ergin; Bulut, Cemal; Caliskan, Okan…Öğe The role of CD14 gene promoter polymorphism in tuberculosis(Academic Press Ltd- Elsevier Science Ltd, 2011) Ayaslioglu, Ergin; Kalpaklioglu, Fusun; Kavut, Ayse Bascioglu; Erturk, Arzu; Capan, Nermin…Öğe The role of CD14 gene promoter polymorphism in tuberculosis susceptibility(Elsevier Taiwan, 2013) Ayaslioglu, Ergin; Kalpaklioglu, Fusun; Kavut, Ayse Baccioglu; Erturk, Arzu; Capan, Nermin; Birben, EsraBackground: CD14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in the innate immunity to intracellular infections. Recent research findings have revealed an association between the CD14 gene promoter polymorphism and several major infectious diseases. Objective: The aim of the present study was to investigate the association between the CD14-159C/T polymorphism and tuberculosis in a Turkish population. Methods: For this purpose, 88 consecutive patients with tuberculosis (63 pulmonary, 25 extra-pulmonary) and 116 control subjects were enrolled into a prospective study. We determined CD14-159 genotypes by polymerase chain reaction - restriction fragment length polymorphism analysis and also measured serum concentrations of soluble CD14 (sCD14) by using a quantitative sandwich enzyme immunoassay technique. Results: There was no significant difference in terms of genotype distribution between patients with tuberculosis (CC 18.2%, CT 48.9%, TT 33.0%) and controls (CC 12.9%, CT 50.9%, TT 36.2%) or between patients with pulmonary and extrapulmonary tuberculosis. Serum levels of sCD14 were significantly increased in patients with active tuberculosis compared to those with inactive tuberculosis and healthy controls (p < 0.001). However, levels of sCD14 were not associated with any genotypes of CD14-159. Conclusion: The genotyping findings of the present study do not support a role for the CD14-159C/T polymorphism in the development of tuberculosis, at least in the geographical region of central Anatolia. Significantly elevated serum sCD14 levels in patients with active disease reflect the importance of the mononuclear phagocytic system activation in tuberculosis. Copyright (C) 2012, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. All rights reserved.Öğe Sandfly fever virus as a rare cause of acute viral hepatitis(Elsevier Sci Ltd, 2014) Ayaslioglu, Ergin; Guliter, Sefa; Karabicak, Cigdem; Ecemis, Kenan; Gulhan, Muhammet; Edis, Cigdem Torun…Öğe Serum soluble CD30 levels in Behçet's disease(2004) Düzgün, Nursen; Ayaslioglu, Ergin; Tutkak, HüseyinBehçet's disease is associated with the inflammatory response. Several reports indicate the presence of primarily CD4+ T cells of the Th1 subtype in the inflammation process of the disease. Serum soluble CD30 (sCD30) is reported to be released from CD4+ Th2 type cells and has been suggested to be a marker of Th2 activity. In this study, serum sCD30 levels were measured in active and inactive patients with Behçet's disease, healthy controls and a group of patients with rheumatoid arthritis, typical Th1 disorder using enzyme immunoassay kit. Mean sCD30 value of 54 active patients were found significantly higher than in those of 17 inactive patients (p = 0.027), 20 healthy controls (p = 0.040) and 25 patients with rheumatoid arthritis (p < 0.001). There was a significant correlation between increased sCD30 levels and clinical activity index in active patients with Behçet's disease. High serum levels of sCD30 may reflect the activation qf CD4+ T cells or a subset of them in active BD patients. In addition to serum sCD30 levels, measurements of the Th2 cytokines may be a helpful tool for the evaluation of Th2 activity in Behçet's disease. © Copyright Clinical and Experimental Rheumatology 2004.Öğe The resistance of Gram-negative rods against isepamicin and other aminoglycosides(Aves, 2005) Kaygusuz, Sedat; Ayaslioglu, Ergin; Ozluk, Ozlem; Kilic, DilekThis study was conducted to investigate the resistance of Gram-negative rods against isepamicin and other aminoglycosides. Resistance against five different aminoglycosides were tested in 861 Gram-negative microorganisms which were isolated in nosocomial infections, including 546 Escherichia coli, 116 Proteus spp., 87 Klebsiella spp., 56 Enterobacter spp. and 56 nonfermentative bacteria. The microorganisms from various infection sites tested by using the disk diffusion method according to NCCLS recommendations. The resistance rates of all Gram-negative bacteria included in the study were 0.8% for isepamicin, 2.0% for amikacin, 2.1% for netilmicin, 5.9% for gentamicin and 7.9% for tobramycin. We conclude that isepamicin is the aminoglycoside with highest activity, and tobramycin with highest resistance rate. The resistance of aminoglycoside should be controlled and the use of rational antibiotic should be taken into condideration in nosocomial infections.
