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Öğe Conservative treatment of femoral neuropathy following retroperitoneal hemorrhage: a case report and review of literature(Lippincott Williams & Wilkins, 2014) Tosun, Aliye; Inal, Elem; Keles, Isik; Tulmac, Murat; Tosun, Ozgur; Aydin, Gulumser; Orkun, SevimAnticoagulant drugs are used to reduce the incidence thromboembolic events in patients at risk. However, minor and major bleeding complications may occur during anticoagulation therapy. Femoral neuropathy secondary to retroperitoneal hematoma is a well known complication of anticoagulant drugs. However, treatment of these patients is still controversial, both conservative and surgical treatments have been advocated. Herein, we report a male patient receiving warfarin for 7 years who developed femoral neuropathy due to retroperitoneal hematoma and was successfully treated with conservative methods. We suggest that conservative treatment and appropriate rehabilitation program should be given to the patients who do not demonstrate any signs of a continued bleeding and any progressive neurological deficits. Blood Coagul Fibrinolysis 25:769-772 2014 (C) Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.Öğe Does Autonomic Dysfunction Exist in Postmenopausal Osteoporosis?(Lippincott Williams & Wilkins, 2011) Tosun, Aliye; Dogru, Mehmet Tolga; Aydin, Gulumser; Keles, Isik; Arslan, Ayse; Guneri, Mahmut; Ebinc, HaksunTosun A, Dogru MT, AydNn G, Keles I, Arslan A, Guneri M, Orkun S, Ebinc H: Does autonomic dysfunction exist in postmenopausal osteoporosis? Am J Phys Med Rehabil 2011;90:1012-1019. Objective: The aim of this study was to investigate the presence of autonomic dysfunction in patients with osteoporosis. Design: This is a prospective controlled trial. Sixteen postmenopausal female patients with osteoporosis and 10 age-matched postmenopausal nonosteoporotic controls were included in the study. Participants were divided into the postmenopausal osteoporosis group and the nonosteoporotic control group according to bone mineral densities. Heart rate variability parameters and sympathetic skin responses were studied to evaluate autonomic functions. Results: The latencies of sympathetic skin responses obtained from both hands were significantly increased in the patient group when compared with the control group. The sympathetic skin response amplitude of the right hands and both feet of the patient group were found to be decreased significantly when compared with that of the control group. A 24-hr high-frequency value was significantly decreased in the patient group than in control group. A 24-hr low-/high-frequency value was significantly higher in the patient group than in the control group. Conclusions: Autonomic dysfunction characterized with increased sympathetic and decreased parasympathetic activity may be present in osteoporosis, and cardiac functions in patients with osteoporosis may also be affected by accompanying autonomic dysfunction.Öğe Effects of ovariectomy and ascorbic acid supplement on oxidative stress parameters and bone mineral density in rats(Taylor & Francis Ltd, 2011) Arslan, Ayse; Orkun, Sevim; Aydin, Gulumser; Keles, Isik; Tosun, Aliye; Arslan, Mustafa; Caglayan, OsmanObjectives: The aim of this study is to investigate the effects of ovariectomy on bone mineral density (BMD) and oxidative state in rats, and the alterations in these effects that vitamin C supplementation may produce. Materials and methods: Twenty female Wistar albino rats were randomly divided into three groups: control (C, n = 6); ovariectomy (O, n = 7); and ovariectomy + vitamin C supplement (OV, n = 7). Oxidative stress (OS) was assessed 100 days postovariectomy by measuring the activity of several enzymes, including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase, as well as the concentrations of malondialdehyde (MDA), nitric oxide (NO), and total sulfhydryl groups in plasma and bone homogenates. Results: A significant decrease in BMD was observed in O group compared with C group (p = 0.015), and a significant increase was observed in OV compared with O group (p = 0.003). When groups were compared with respect to parameters of OS, MDA and NO levels in bone tissue were significantly higher in O than in C (p = 0.032, p = 0.022) and were significantly lower in OV than in O (p = 0.025, p = 0.018). SOD activity was significantly higher in O than in C (p = 0.032). In plasma, MDA activity was significantly higher in O than in C (p = 0.022) and NO level was significantly higher in O than in C and OV (p = 0.017, p = 0.018). Conclusions: Our results suggest that ovariectomy may produce osteoporosis and OS in females, and vitamin C supplementation may provide alterations regarding improvement in OS and BMD values. We assume that studies including more subjects are needed to make a decisive conclusion about OS-BMD relation.Öğe Electrophysiologic evaluation of cremasteric reflex in experimental orchitis(Elsevier Sci Ltd, 2013) Soyer, Tutku; Inal, Elem; Boybeyi, Ozlem; Balci, Mahi; Aslan, Mustafa Kemal; Aydin, GulumserAim: Absent cremasteric reflex (CR) is a well known but not reliable sign of testicular torsion. We hypothesized that CR can also be altered in other causes of acute scrotum in children. An experimental study was performed to evaluate the clinical and electrophysiological features of CR in orchitis. Method: Eighteen Wistar albino rats were allocated into three groups: control (CG), sham (SG) and orchitis (OG). In CG, after anesthetization with ketamine hydrochloride, the medial site of the anterior superior iliac spine was stimulated to obtain CR electrophysiologically, and latency and duration were recorded with a needle electrode placed in the cremasteric muscle. Electrophysiologic evaluations were performed 24 h after injection of 0.1 ml of 10(6) cfu/ml Escherichia coli (0: 6 strain) in 1 ml of physiologic saline into the right testicle in OG, and 1 ml of saline only in SG. All testicles were sampled to check for orchitis after the electrophysiologic evaluations. Results: CR was obtained in all rats in CG and in 83.3% and 66.6% in SG and OG respectively (p < 0.05). The latency of CR was significantly higher in OG (15.1 +/- 0.9 ms) and SG (15.5 +/- 1.2 ms) than CG (10.5 +/- 0.7 ms) (p < 0.017). The duration of CR was 15.1 +/- 3.2 ms in CG, 16.2 +/- 4.9 ms in SG and 18.5 +/- 3 ms in OG (p > 0.05). Histopathologic confirmation of orchitis was obtained in all testicle samples in OG, and number of neutrophils and total orchitis score was significantly higher in OG than the other groups (p < 0.05). Conclusion: Electrophysiologic parameters of CR may be altered in orchitis. Prolonged latency of CR in orchitis may be due to inflammation of the genitofemoral nerve or cremasteric muscle. (C) 2013 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.Öğe Lipoma Arborescens in Childhood: A Report of Two Sisters(Turkish League Against Rheumatism, 2012) Aydin, Gulumser; Keles, Isik; Tosun, Ozgur; Tosun, Aliye; Yilmaz, Latife Ozlem; Karagulle, Tuba Kendi; Orkun, SevimLipoma arborescens (LA) is a rare benign lesion of synovial joints and bursae. The knee is the most common site of the involvement. Magnetic resonance imaging findings are typical in the diagnosis. The number of case reports of LA in children is significantly lower compared to the adults. In this article, two nine-year-old and 15-year-old sisters who were examined for the complaints of bilateral pain and swelling in knees were presented. Magnetic resonance imaging demonstrated typical features of LA in the right knees of both children. Pediatric patients with mono/oligoarticular effusion and synovial hypertrophy without systemic involvement, LA should be considered in differential diagnosis. Magnetic resonance imaging is a sensitive modality in the diagnosis of LA.
