Yazar "Aydos, Tolga R." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Effect of Naloxone on Oxidative Stress and Testicular Injury due to Spermatic Vessel Ligation of Rat Testis
    (Karger, 2008) Cakan, Murat; Yilmazer, Demet; Cakan, Turkay; Aydos, Tolga R.; Ogus, Elmas; Kilinc, Aytun S.; Altug, Ugur
    Aims: Two-stage Fowler-Stephens orchiopexy has been accompanied by testicular atrophy in some cases but neither of the mechanisms responsible for testicular injury are clear, nor is there an effective agent that might prevent this injury. In this study we aimed to investigate the long-term effects of naloxone, a morphine antagonist, on testicular histopathology and oxidative stress after spermatic vessel ligation (SVL) in rats. Methods: 32 prepubertal rats were randomly divided into four equal groups: group 1: control (only bilateral orchiectomies were performed); group 2: sham-operated group; group 3: SVL, and group 4: SVL+naloxone (1 mg/kg twice daily for 1 month). One month postoperatively, bilateral orchiectomies were performed to evaluate histopathologic findings and measurement of malondialdehyde (MDA) and nitric oxide (NO) levels. Results: Considering group 3, left SVL resulted in significant tissue damage in both testes, more severe in the ipsilateral testis. The SVL resulted in a significant increase in testicular MDA levels of both testes in this group (p < 0.05). While the ipsilateral testicular NO levels of groups 2 and 3 were significantly lower than of group 1 (p < 0.05), the contralateral testicular NO levels of all these groups were similar. After naloxone therapy, while there was no significant improvement in ipsilateral testicular histopathology (p > 0.05), the contralateral testicular histopathology improved significantly (p < 0.05). However, naloxone did not change either testicular MDA or NO levels. Conclusions: The SVL led to bilateral testicular injury, and oxidative stress may be a reason for this injury. Naloxone significantly improved contralateral testicular injury without showing any antioxidative effect. Copyright (c) 2008 S. Karger AG, Basel
  • [ X ]
    Öğe
    The Smooth Muscle Contractility In Aflatoxicated Broiler Chicken Ileum
    (Parlar Scientific Publications (P S P), 2013) Yildirim, Ebru; Aktuna, Zuhal; Yalcinkaya, Ilkay; Eraslan, Gokhan; Kanbur, Murat; Aydos, Tolga R.; Oruc, Ertan
    This study was conducted to investigate the contractility of aflatoxicated isolated broiler ileum smooth muscles. Fourty-eight, one-day old broiler chicks were divided into 4 groups, each containing 12 chicks. The 1st group was the control group, the 2nd group received 1 g/kg yeast glucomannan (Mycosorb), the 3rd group received 2 mg/kg aflatoxin, and the 4th group received 1 g/kg yeast glucomannan + 2 mg/kg aflatoxin in the feed. At the 21st day of the study, chicks were decapitated and the ileum isolated. Decapitation lasted on 28th day of the study. The isolated ileum strips were mounted under a basal tension of 1 g. The contractions of acetylcholine (ACh), nicotine, and bethanechol were calculated as g contraction/mg wet weight of ileum. For histopathologic examination, ileum sections were stained with hematoxylin-eosin and masson trichrome. The isolated ileum muscle contractions with ACh, nicotine, and bethanechol were not statistically significant in the study groups as compared to control group (P>0.05). Pathological examination revealed no histopathological changes in the smooth muscle tissues of the study group chicks when compared with control group. It is concluded that aflatoxins do not specifically change the contractility of broiler chick ileum to agonists most likely due to lack of aflatoxin-induced pathologic changes in the broiler chick ileum.