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Protective effects of ketoprofen on oxidative stress and histopathological changes in testicular ischemia-reperfusion injury in a rat
(2007) Çakan Murat; Çakan Türkan; Aydos Tolga; Yilmazer Demet; Öğüş Elmas; Kılıç Aytun S.
Introduction: Testicular torsion is a common surgical emergency affecting newborns, children and adolescents. A possible cause of testicular injury is ischemia-reperfusion (I/R) injury. In this study we evaluated the effect of ketoprofen, a non-steroidal anti-inflammatory drug, on I/R injury due to testicular torsion-detorsion (T/D). Materials and Methods: Twenty-eight prepubertal male Wistar rats were divided into four groups each containing 7 rats: Group 1, control; Group 2, sham; Group 3, T/D; and Group 4, T/D+ketoprofen. Group 3 and 4 underwent 2 hours of left testicular torsion and 4 hours of detorsion. In Group 4, ketoprofen (5 mg/kg) was administrated intraperitoneally 60 minutes before detorsion. At the end of the study, bilateral orchiectomies were performed for measurement of MDA and NO levels and histopathologic examination. Results: Testicular torsion-detorsion significantly induced oxidative stress and tissue damage in both ipsilateral and contralateral testes. Administration of ketoprofen significantly lowered MDA level and improved histologic parameters of spermatogenesis in both testes. Conclusion: Ketoprofen has a protective effect on testicular ischemia-reperfusion injury due to testicular torsion/detorsion.