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    The Comparison of the Incidence of Horseshoe Kidney in Autopsy Cases Versus Urologie Patient Population
    (1999) Başar, Halil; Başar, Ruhgün; Başar, M.Murad; Erbil, Mine
    This study was applied on 9665 cases between January 1993 and October 1998. Of these, 6985 (72.3%) were urologic patients and 2680 (27.7%) were autopsy cases. The patients having urinary complaint investigated by urine analysis and kidney-ureter-bladder film (KUB), routinely. In all patients who have pathological urine, ultrasonography exam was done and in all patients who established an abnormality on ultrasonografy, intravenous pyelography (IVP) was taken, also. We established the horseshoe kidney in 23 of patients (1/304) and in 6 of autopsy cases (1/447) with overall incidence 1/333. There were 21 male and 8 female with horseshoe kidney (male/female = 2.6/1). Abdominal discomfort with lower lumbar pain and Rovsing's sign were seen in 56.5% and in 65.2% of patients respectively. We concluded that horseshoe kidney incidence is almost the same as reported in the literature, although its clinical appearance is higher in our urologic patient population. In the urological out-patient evaluation, at least Rovsing's sign should be applied to all patients with lower lumbar pain with vague abdominal discomfort and an abdominal ultra-sonographic exam should be applied, if this sign is positive.
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    Seminal Plasma Transforming Growth Factor-β (TGF-β) and Epidermal Growth Factor (EGF) Levels in Patients with Varicocele
    (2008) Kısa, Üçler; Başar, M.Murad; Ferhat, Mehmet; Çağlayan, Osman
    Aims: The aim of this study was to analyze seminal plasma epidermal growth factor (EGF) and transforming growth factor-? (TGF-?) levels in infertile patients with varicocele and normal fertile cases, and to evaluate the relationships between seminal plasma EGF and TGF-?, seminal parameters and serum hormone levels. Materials and Methods: A total of 100 patients with varicocele were enrolled into the study. Semen analyses were performed after 2 and 5 days of sexual abstinence. These patients were divided into two groups based on the results of semen analysis as oligoasthenoteratozoospermia (Group 1) and normal semen analysis (Group 2). Additionally, 100 fertile cases without any scrotal pathology were accepted as the control group (Group 3), and semen analysis was also performed in these cases. Seminal plasma EGF and TGF-? levels were measured with ELISA. Additionally, serum gonadotropin and serum sex steroid levels were measured in patients and controls. Statistical analysis was performed by using one-way ANOVA test and post hoc Bonferroni test. Results: There was a statistically significant difference between patients and controls regarding seminal parameters (P < 0.05). Seminal plasma EGF and TGF-? levels were higher in patients with varicocele (Group 1 and Group 2) than Group 3; however, there was a statistically significant difference only in TGF-? levels (P = 0.017). Seminal plasma EGF and TGF-? levels showed a negative relationship with seminal parameters (P < 0.005). However, there was no relationship between these growth factors and serum hormone levels. Conclusions: This study showed that increased levels of EGF and TGF-? were associated with decreased seminal parameters in patients with varicocele. However, the relationship was more evident with TGF-?. © TÜBİTAK.