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Öğe Cricoarytenoiditis in rheumatoid arthritis: Radiologic and clinical study(B C Decker Inc, 2003) Bayar, N.; Kara, S.A.; Keles, I.; Koç, C.; Altinok, D.; Orkun, S.The cricoarytenoid (CA) joint involvement in rheumatoid arthritis (RA) is not uncommon. In this study, clinical assessment, laryngeal endoscopy, and high-resolution computed tomography (HRCT) were used in 15 patients with RA to evaluate the diagnostic criteria of CA joint involvement. Symptoms owing to CA joint involvement were present in 66.6% of the patients. The frequency of involvement was 13.3% on laryngeal endoscopy but 80.0% with HRCT assessment. The most common HRCT findings were CA prominence (46.6%), density and volume changes (46.6%), and CA subluxation (39.9%). In some of the patients, soft tissue swelling (20%) near the CA joint and narrowing in the piriform sinus (33.3%) were also observed. Radiologic abnormalities related to CA joint involvement generally precede clinical symptomatology. Therefore, HRCT evaluation may be a useful method in the assessment of CA joint involvement in RA patients to exclude possible causes of laryngeal signs and symptoms.Öğe Effects of electrohydraulic extracorporeal shock wave lithotripsy on submandibular gland in the rat: electron microscopic evaluation(Elsevier Sci Ireland Ltd, 2002) Bayar, N.; Kaymaz, F.F.; Apan, A.; Yilmaz, E.; Cakar, A.N.Objectives: Extracorporeal shockwave lithotripsy (ESWL) has been applied in sialolithiasis as a new treatment modality. The aim of this experimental study is to investigate the local effects of electrohydraulic ESWL applied to the right submandibular gland of the rats. Methods: This prospective study was conveyed in four groups groups I, II, III and IV: each group consisting of 20, 20, 18 and 9 rats, respectively, with a randomized distribution, Groups I, II, III and IV received 250, 500, 1000 and 2000 shock waves at 14-16 kV (average 15.1 kV), respectively, to the right submandibular glands on the 0th day. In groups I, II, III, right submandibular glands of the rats were removed on the 0th 1st, 7th and 15th days, in group IV, this procedure could be managed only on the 0th and 7th days. Light and electron microscopic evaluation were assessed, Using the light microscopic changes, severity of damage score of the glands (SDS) was found. Statistical analysis was done using SDSs. Results: Light and electron microscopic observations have shown that the damage produced by the shock waves were confined to focal areas in the acinar cells (AC), granulated convoluted tubule (GCT) cells and blood vessels at all doses applied. Vacuolization in the cytoplasms of the AC and GCT cells, disintegration of membranes, alteration in the cytoplasmic organization, swelling of the mitochondria and loss of the features were observed on electron microscopy. Increase in the secretion rate; stasis and dilatation in the blood vessels: blebbing and loss of features in the cytoplasm of the endothelial cells were observed, According to the result of the statistical analysis using SDSs, at 250 shock wave dose, a statistically significant difference between the SDSs of the days (0th, 1st, 7th and 15th) was found (P < 0.05), The SDS on the 0th day was found to have the lowest value among the other days. And also a statistically significant difference was found on the 0th day between the SDSs at doses of 250, 500, 1000 and 2000 shock waves (P < 0.05). The SDS at 250 and 500 shock waves was found to have the lower value than the SDS at the 2000 shock wave. It was observed that produced damage was less prominent by small doses (250, 500 doses) initially (0th day). Electrohydraulic ESWL caused a "patchy type" generalized pathology on submandibular glands of the rats and damaged focal areas were widespread all through the gland from the 1st day on. Conclusion: Formation of the damage was concluded to be related to the direct effect of the shock waves rather than the dose used. Electrohydraulic lithotripters are not suitable for sialolithiasis because of the focus problems, local tissue damage and the risk of the damage to the adjacent structures. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.Öğe Efficacy of amitriptyline in the treatment of subjective tinnitus(B C Decker Inc, 2001) Bayar, N.; Böke, B.; Turan, E.; Belgin, E.We investigated the effect of amitriptyline, a tricyclic antidepressant, on patients with subjective tinnitus. The study group consisted of 37 adult patients admitted to the Ear, Nose, and Throat and Audiology Department of Hacettepe University. The amitriptyline group consisted of 20 patients and the placebo group consisted of 17 patients. All of the patients were evaluated using a questionnaire, audiologic evaluation, high-frequency audiometry, impedancemetric tests, auditory brainstem response, tinnitus frequency, and loudness matching assessed by audiometric methods at the beginning and end of the study. The patients in the amitriptyline group received 50 mg/day amitriptyline in the first week and 100 mg/day for the following 5 weeks. In the placebo group, the patients received tablets consisting of lactose starch for 6 weeks, with a dosage of 1 tablet/day. The subjective complaints of the patients in the amitriptyline group decreased, and the "present" symptoms resulted in fewer complaints. The severity of tinnitus decreased in the amitriptyline group by means of subjective and audiometric methods. In the placebo group, no significant change was observed. The success of treatment was 95% in the amitriptyline group and 12% in the placebo group. Amitriptyline therapy was concluded to be effective.Öğe Efficacy of topotecan treatment on an experimental model of transient evoked otoacoustic emissions(Elsevier Ireland Ltd, 2001) Bayar, N.; Boke, B.; Apan, A.; Koc, M.C.Objective: The aim of this study was to investigate the effects of topotecan (Hycamtin(R)), a topoisomerase I inhibiting anticancer agent, on Transient Evoked Otoacoustic Emissions (TEOAEs) of the rabbits. We planned to investigate whether this test might provide a method for monitoring early ototoxic influence of drug administration to the cochlea. Methods: The study was conveyed in two groups each consisting of five rabbits with a total of ten ears. Rabbits in group I received i.v. topotecan (0.5 mg/kg once daily) for 3 days. Rabbits in group II received i.v. topotecan (0.25 mg/kg once daily) for 3 days. Cochlear function was serially monitored using transient evoked otoacoustic emissions before administration (BA) and on the 4th and 15th days after administration of topotecan. TEOAEs were analysed in terms of mean stimulus, stability and emission amplitude at 1.0-4.0 kHz. Results: For group I and II, intergroup and intragroup, differences were not statistically significant in the mean stimulus, stability and emission amplitudes at 1.0-4.0 kHz. Conclusions: We evaluated the potential role of TEOAEs in early identification of cochlear dysfunction induced by, topotecan. It was concluded that topotecan did not have ototoxic effects on the cochlea in the early period of administration. TEOAEs may be useful: to monitor the cochlear function and to detect the late stage of ototoxicity especially in the presence of potentially toxic factors for the prevention of permanent damage. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.Öğe Minnesota multiphasic personality inventory profile of patients with chronic sinusitis(Int Rhinologic Soc, 2001) Bayar, N.; Oğuztürk, O.; Kazkayasi, M.; Koç, M.C.Chronic sinusitis is one of the most common diseases in the general population. We investigated the personality traits of non-psychiatric patients in chronic sinusitis and non-sinusitis groups. In this study we evaluated 25 patients with chronic sinusitis and 25 subjects as a control group. In the analysis of the psychiatric status, MMPI profiles were used. We found that the depression and social introversion subscales were higher in males, whereas the hypochondriasis and social introversion subscales were higher in females with chronic sinusitis. It is concluded that the psychological functions of the patients with chronic sinusitis are poorer than in the non-sinusitic group.Öğe Minnesota multiphasic personality inventory profile of patients with subjective tinnitus(B C Decker Inc, 2002) Bayar, N.; Oguztürk, O.; Koç, C.Subjective tinnitus is frequently seen in the general population. We investigated the personality traits in tinnitus and nontinnitus groups, both of which were nonpsychiatric. In this study, we evaluated 28 patients with subjective tinnitus and 28 subjects for a control group. In the analysis of psychiatric status, Minnesota Multiphasic Personality Inventory (MMPI) profiles were used. Psychasthenia was found to be higher in tinnitus patients of both sexes, whereas Hypochondriasis, Hysteria, Masculinity/Feminity, Psychasthenia, Schizophrenia, and Social Introversion scores were higher in females with tinnitus. In our research, it is thought that the experience of tinnitus may cause the psychological disturbance.Öğe Temporomandibular joint involvement in rheumatoid arthritis: A radiological and clinical study(Taylor & Francis Ltd, 2002) Bayar, N.; Kara, S.A.; Keleş, I.; Koç, M.C.; Altinok, D.; Orkun, S.Temporomandibular joint (TMJ) involvement in rheumatoid arthritis (RA) is not uncommon. In this study a questionnaire, clinical assessment, and high resolution computerized tomography (HRCT) were used in 15 patients with rheumatoid arthritis to evaluate the diagnostic criteria of TMJ involvement. Symptoms due to TMJ involvement were present in 33.3% of the patients. Frequency of involvement was 40.0% on clinical assessment but 86.6% with HRCT assessment. The most common HRCT findings were decreases in the joint space (33.3%) mandibular subchondral cysts (23.3%), temporal subchondral cysts (23.3%), degeneration (23.3%), shape (13.3%) and height (13.3%) anomalies of the mandibular condyle, condylar head resorption (13.3%), erosion of the mandibular condyle (13.3%), and demineralization (13.3%). All patients with positive clinical findings also had positive HRCT patients, there were no symptoms or clinical findings implying TMJ findings. In seven (46.7%) of the involvement; however, they had positive results on HRCT evaluation. The HRCT findings may be the initial sign of TMJ involvement in patients with rheumatoid arthritis. In conclusion, it is suggested that RA patients with the suspicion of TMJ involvement should undergo HRCT evaluation, because HRCT findings may precede the clinical findings.Öğe Total removal of an unruptured orbital hydatid cyst(Canadian Ophthal Soc, 2001) Gökçek, C.; Bayar, N.; Buharai, Z.…
