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  • Küçük Resim
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    Can Dehydroepiandrosterone-Sulphate be a New Diagnostic Parameter in Idiopathic Hypogonadotropic Hypogonadism?
    (Galenos Publ House, 2022) Çadırcı, Kenan; Keskin, Havva; Bayrak, Muharrem; Çarlıoğlu, Ayşe; Ceylan Arıkan, Senay
    Objective: Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEA-sulfate (DHEA-s) are major androgen hormones which are synthesis from the adrenal origin. The purpose of this study was to investigate DHEA-s levels in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and to determine whether DHEA-s level are a useful marker for diagnosis of IHH.Methods: A total of 91 subjects, 31 males with IHH (mean age 19.7 +/- 2.6 years) and 60 healthy males (mean age 20.7 +/- 2.6 years), were enrolled in this study. The patients with IHH were selected from the subjects who had not yet started treatment for hypogonadism and who had no additional disease, while the healthy control group consisted entirely from individuals admitted to the same hospital outpatient clinic for routine check-ups. Both groups' blood sampling, anthropometric measures, and physical examination were undertakenResults: Mean DHEA-s level was 133.4 +/- 56.5 mu g/dL in the IHH group and 433.3 +/- 160.3 mu g/dL in the control group (p=0.000). The low DHEA-s level in patients with IHH was independent of age, cortisol, and adrenocorticotropic hormone (ACTH) at multivariate logistic regression analysis. The ROC analysis showed that DHEA-s <= 38.2 mu g/dL supports a diagnosis of IHH with 100% specificity and 100% sensitivity. DHEA-s was as predictive as total testosterone which is used in the diagnosis of patients with IHH.Conclusion: DHEA-s level was significantly lower in the males with IHH compared to controls. Therefore, DHEA-s may be a potential predictive marker for diagnosis of IHH.
  • Küçük Resim
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    Familyal hipokalsiürik hiperkalsemili olgularımız
    (2017) Bayrak, Muharrem; Çadırcı, Kenan; Çarlıoğlu, Ayşe; Sevimli¹, Hakan; Durmaz, Şenay
    Ailesel hipokalsiürik hiperkalsemi, ılımlı hiperkalsemi, idrarda kalsiyum atılımının az olması ile giden ve kalsiyum duyarlı reseptörlerde mutasyonlardan kaynaklanan benign bir hastalıktır. 2010 Ocak ile 2015 Haziran ayları arasında İç hastalıkları polikliniğimize başvuran altı hasta klinik ve biyokimyasal parametrelerle değerlendirilmiştir. Olgularımız, 21 ile 86 yaş arasında, dördü kadın olmak üzere toplam altı hasta idi. Beş olgumuzun çocukları ve bir olgumuzun ebeveynleri poliklinik ortamında değerlendirildi. Olguların değerlendirmesinde ılımlı hiperkalsemi, sınırda yüksek parathormon düzeyleri ve idrarla günlük kalsiyum atılımının belirgin düşüklüğü nedeniyle ailesel hipokalsiürik hiperkalsemi olabileceği düşünüldü. Beş erişkin hastanın çocuklarında ve bir genç hastamızın da annesinde kalsiyum metabolizmasında benzer laboratuvar bulguları saptanması ve hiperkalsemi yapan diğer nedenlerin dışlanması üzerine tanı doğrulandı.
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    Öğe
    Investigation of the neutrophil/lymphocyte and monocyte to high-density lipoprotein cholesterol ratios in differentiated thyroid cancers
    (2020) Dal, Derya; Yıldız, Faruk; Keskin, Havva; Bayrak, Muharrem; Özmen, Hilal Kızıltunç; Durmaz, Şenay; Çarlıoğlu, Ayşe
    Introduction: Thyroid cancers are the most common malignant tumors of endocrine origin. They are classified depending on their histopathological and clinical behaviors. Papillary and follicular cancers are classified as differentiated thyroid carcinomas (DTCs). The neutrophil/lymphocyte ratio (NLR) and the monocyte to highdensity lipoprotein cholesterol ratio (MHR) have recently been shown to be powerful markers of oxidative stress and systemic inflammation, and the MHR has been revealed as a potent marker of mortality in coronary heart disease associated with coronary atherosclerosis. The aim of this study was to evaluate these markers in patients diagnosed with DTC. Material and Method: One hundred twenty-five patients newly diagnosed with DTC and a 75-member control group consisting of entirely healthy individuals were included in the study. The patient and control groups were evaluated by investigation of cholesterol and hematological parameters following 12-h fasting. Results: Significant differences were determined between the patient and control groups in terms of mean NLR (3.2±2.8 vs 2.4±1.3, respectively, p=0.013) and MHR (0.102±0.079 vs, 0.038±0.052 respectively, p<0.001) values. In the correlation analysis, positive correlation was determined between the NLR and white cell count (r=0.530, p<0.001), neutrophil count (r=0.293, p<0.001) and C reactive protein (CRP) (r=0.371, p=0.005), while negative correlation was determined between the NLR and lymphocyte count (r=-0.271, p=0.001). Conclusion: The study data show that DTCs increase systemic inflammation.
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    Öğe
    The Frequency of MEFV Gene Mutations for Familial Mediterranean Fever
    (Kırıkkale Üniversitesi, 2019) Bayrak, Muharrem; Çadırcı, Kenan; Yaralı, Oğuzhan
    Objective: Familial mediterranean fever is anautosomal recessive genetic disease caused by mutations in the MEFV genes. Itwas aimed to determine the types and frequency of MEFV mutations in Familialmediterrenean fever cases due to the fact that there is a common geneticdisease in our region and a low epidemiological data related to the mutations.Material and Methods: Atotal of 212 FMF patients with MEFV mutations wereincluded in the study. The data of the patients were retrospectively reviewed. The MEFV mutation analyses wereperformed using the NextGeneration Sequence method.Results: Of thesepatients, 116 (54.71%) were female and 96(45.29%) were male. M694V (34.9%) was the most common mutation type, E148Q (26%), V726A (16%), M68OI (8.3%)were the other common mutation types. When the distribution of patientswith MEFV mutation was examined according togender, it was observed that M694V, E148Q, V726A, M68OI, and R761H mutationswere more frequent in men while M694V, E148Q, V726A, M68OI, and P369S mutations weremore frequent in women.Conclusion: In our study which was conducted to determinethe frequency of MEFV mutation types, it has been shown that familialMediterranean fever disease is observed in a high rate in some regions and ithas also shown that these different rates can lead to differences betweensocieties. We think that the frequency ofMEFV mutation types may change from region to region and from populationto population. Therefore, because of changing population and the instability ofneighboring countries, large population-based studies aimed to determine thefrequency of MEFV mutation types should be made due to the in our region and inour country.