Yazar "Bayraktar, Mehmet Refik" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim
    Öğe
    Changes in the rates of antimicrobial resistance among clinical isolates of Pseudomonas aeruginosa between 2002 and 2004 in a tertiary-care teaching hospital in Turkey
    (Edizioni Int Srl, 2008) Iseri, Latife; Bayraktar, Mehmet Refik
    Pseudomonas aeruginosa is an important opportunistic pathogen usually resistant to most antimicrobials. We present changes in the resistance pattern of R aeruginosa to amikacin (AK) and ciprofloxacin (CIP) between January 2002 and June 2004. The physicians of each unit were given information on antibiotic resistance rates of P aeruginosa isolated from ward patients at regular intervals. The antibiotic resistance of 161 P aeruginosa isolates isolated from intensive care units (ICUs) and non-ICUs were tested by disk diffusion method, and the results were interpreted according to the guidelines of National Committee for Clinical Laboratory Standards. Thirty-five percent of all the P aeruginosa isolates were resistant to AK in 2002, 18% in 2003, and 20% in 2004. The CIP resistance rates were 4% in 2002, 26% in 2003 and 20% in 2004. In that period, resistance to AK decreased, whereas resistance to CIP increased. The usage rate of AK in 2002 was 32%, which fell to 26% in 2003 (p<0.05). This rate increased to 27% in 2004 (p<0.05). The usage rate of CIP was very low in 2002 (3%). Subsequently, it increased to 8% in 2003 and 2004 (p<0.05). The changes in resistance rates may have been due to alteration in drug usage policy in our hospital. It is important to provide physicians with information on antibiotic resistance rates at regular intervals to guide therapy for critical P. aeruginosa infections.
  • Küçük Resim
    Öğe
    The consistency of total immunoglobulin E with the symptoms according to age and the selection of allergy panels in Malatya (Turkey)
    (Pharmaceutical Soc Japan, 2007) Abut, Latife; Apan, Teoman Zafer; Bayraktar, Mehmet Refik
    Distribution of allergens may change according to characteristics of regions. Measurements of total immunoglobulin E (TIE) and specific IgE antibodies are used to diagnose allergic diseases. In this study, we investigated sensitivity of TIE and its consistency with allergic symptoms, and compared the appropriateness of some allergy panels with features of Malatya, south-eastern Turkey province. Sera of 233 allergic patients of various age groups were tested for TIE. The specific IgE's were worked with 529 sera for food panel 5 (FP5) and one inhalant panel by using chemiluminesence technique. The sixty of inhalant panel positive sera were tested with specific IgE against house dust mites, Dermatophagoides pteronyssinus and Dermatophagoides farinae. The specific IgE against egg white, milk, wheat, corn, tomato, beef, strawberry and banana were investigated in sixty of FP5 positive sera by enzyme immunoassay method. The sensitivity of TIE was found to be 85%. We concluded that TIE can be used as a scanning test in children aged 5-18 years (69% positive) but it is not useful for 0-5 age group nor in adults (38%, 53% positive, respectively). The allergen scanning test panels should be designed according to custom of society and characteristics of the region.
  • Küçük Resim
    Öğe
    Investigation of an outbreak of Salmonella Typhi in Battalgazi district, Malatya-Turkey
    (Soc Brasileira Microbiologia, 2009) İşeri, Latife; Bayraktar, Mehmet Refik; Aktaş, Elif; Durmaz, Rıza
    Salmonella Typhi infections are important public health problems for the developing countries. In this study we investigated the molecular epidemiology of a suspected well-water borne S. Typhi outbreak occurred in a district of Malatya-Turkey. This outbreak affected 10 patients in two days. Arbitrary primed polymerase chain reaction (AP-PCR) based typing showed two clones, one had seven, and the other had three strains, supporting outbreak speculation. By adding chlorine to wells by local municipal authority, the outbreak ended within a very short time (about ten days).
  • Küçük Resim
    Öğe
    Multiple-Locus Variable-Number Tandem-Repeat Analysis Genotyping of Human Brucella Isolates from Turkey
    (Amer Soc Microbiology, 2011) Kilic, Selcuk; Ivanov, Ivan N.; Durmaz, Riza; Bayraktar, Mehmet Refik; Ayaslioglu, Ergin; Uyanik, M. Hamidullah; Kantardjiev, Todor V.
    A multiple-locus variable-number tandem-repeat analysis (MLVA) was applied to investigate the epidemiological relationship and genetic diversity among 162 human Brucella isolates collected from all geographic regions of Turkey in an 8-year period (2001 to 2008). The isolates were genotyped by using an MLVA assay developed in Orsay, France (MLVA-16(Orsay)) including eight minisatellite (panel 1) and eight microsatellite (panel 2, subdivided into 2A and 2B) markers. Panels 1 and 2A distinguish 14 genotypes; two of these represented 85% of the strains. Panel 2B displayed a very high discriminatory power. Three loci from panel 2B had diversity index values higher than 0.74. MLVA-16(Orsay) yielded 105 genotypes; 73 were represented by a unique isolate, and 32 included two to eight isolates. The isolates from different patients within the same outbreak or from the same patient before first-line therapy and after relapse showed identical genotypes. A number of MLVA genotypes appeared to be partially restricted to some geographic areas and displayed no annual variation, possibly reflecting persistence of genotypes in certain areas for a time span of at least a decade. This study, representing the first molecular typing results of human Brucella isolates from Turkey, indicated that Turkish human Brucella melitensis isolates were most closely related to the neighboring countries' isolates included in the East Mediterranean group.