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    Effect of smoking on folic acid and vitamin B-12 after nonsurgical periodontal intervention
    (Wiley, 2007) Erdemir, Ebru Olgun; Bergstrom, Jan
    Aim: The main purpose of this study was to investigate the effect of smoking on the serum levels of folic acid and vitamin B-12 in smokers and nonsmokers with chronic periodontal disease after nonsurgical intervention. Material and Methods: The study base consisted of 45 current smokers and 43 nonsmokers. The clinical parameters included plaque index (PI), gingival index (GI), pocket depth (PD), and clinical attachment level (CAL). Folic acid and vitamin B-12 were determined from peripheral blood samples. Clinical measurements and blood samples were collected at baseline and 1, 3, and 6 months after the intervention. Results: Mean PI was significantly greater in smokers compared with non-smokers throughout the observation period (p < 0.001). During the first month, GI levels significantly decreased in both groups. From months 1 through 6, a significant return towards an increased GI level was observed in smokers (p < 0.001). PD and CAL levels significantly decreased during the first month in both groups. Thereafter, increasing levels of PD and CAL were seen in both groups, although significantly more pronounced in smokers. Throughout the observation period, the mean CAL was significantly greater in smokers relative to nonsmokers (p < 0.001). In smokers, the mean folic acid level gradually and significantly decreased and a slight and significant decrease in mean vitamin B-12 levels was observed in both groups over the entire observation period (p < 0.001). Conclusion: The clinical response to nonsurgical intervention is impaired by smoking and smoking seems to negatively influence the serum level of folic acid following non-surgical intervention.
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    Periodontal health in children exposed to passive smoking
    (Wiley, 2010) Erdemir, Ebru Olgun; Sönmez, Isil Saroglu; Oba, Aylin Akbay; Bergstrom, Jan; Çağlayan, Osman
    P>Aim To determine (1) the cotinine levels of saliva, urine and gingival crevicular fluid (GCF) of children in families with and without smoking members and (2) a possible association between the periodontal health of the children and exposure to passive smoking. Material and Methods The study population comprised of 109 children in the age range 6-12 years. Children were classified as exposed to passive tobacco smoking (PTS-exposed, n=51) and as unexposed controls (PTS-unexposed, n=58). Plaque index, gingival index, bleeding on probing, probing depth and clinical attachment level (CAL) were recorded. GCF, saliva and urine samples were also collected. The levels of cotinine in these fluids were determined by enzyme-linked immunosorbent assay. Results The mean salivary cotinine concentration was significantly increased in PTS-exposed children compared with PTS-unexposed children (p < 0.05). Further, in a dose-dependent way, the mean salivary concentration was significantly higher in children whose father or mother was a smoker (p < 0.05) as compared, respectively, with children whose fathers and mothers were non-smokers. The mean CAL was significantly less in PTS-exposed children compared with non-PTS-exposed children (0.09 mm; p < 0.05) and also in children whose father was a smoker (p < 0.05), but not in children whose mother was a smoker as compared with non-smoker fathers and mothers, respectively. The GCF cotinine levels were below the detection limits with the assay method that was used. Conclusions We have observed that children who are exposed to passive smoking have elevated cotinine levels in their saliva concomitant with a lowered CAL.
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    Relationship between smoking and folic acid, vitamin B-12 and some haematological variables in patients with chronic periodontal disease
    (Wiley, 2006) Erdemir, Ebru Olgun; Bergstrom, Jan
    Aim: The purpose of this study was to investigate the relationship between cigarette smoking and the serum levels of folic acid, vitamin B-12 and some haematological variables in patients with periodontal disease. Patients and methods: The study base consisted of 88 volunteer patients with periodontal disease, including 45 current smokers in the age range 31-68 years and 43 non-smokers in the range 32-66 years. The clinical parameters included plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD) and clinical attachment loss (CAL). Folic acid, vitamin B-12 and haematological variables were determined from peripheral blood samples. Results: PI, PD and CAL means were significantly higher in smokers than nonsmokers (p < 0.05). The serum folic acid concentration of smokers was lower than that of non-smokers (p < 0.05), whereas the white blood cell count was higher in smokers than in non-smokers (p < 0.05). Conclusion: The results of this study suggest that among patients with periodontal disease the serum folic acid concentration is lower in smokers compared with non-smokers.