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  • Küçük Resim
    Öğe
    Association Between Tuberculosis and Atopy: Role of the CD14-159C/T Polymorphism
    (Esmon Publicidad S A, 2012) Kavut, A. Baccioglu; Kalpaklioglu, F.; Birben, E.; Ayaslioglu, E.
    Background: The development of allergic hypersensitivity depends on both genetic and environmental factors. Different amounts of microbial products could affect patients with atopy and different genotypes. Objective: We aimed to evaluate the role of varying degrees of exposure to infection by Mycobacterium tuberculosis (tuberculosis) in atopic patients and analyze the association with genetic factors. Methods: We performed CD14-159C/T genotyping in atopic patients (n=118) and healthy individuals (n=62) and recorded the following variables: rural lifestyle, exposure to persons with tuberculosis, bacille Calmette-Guerin (BCG) vaccination, tuberculin skin test (TST), skin prick test, and phenotypes of atopy. Blood samples were analyzed for soluble-CD14 (sCD14), interferon (IFN) gamma, total immunoglobulin (Ig) E, and eosinophil levels. A score was used to identify the likelihood of exposure to tuberculosis. Results: Almost all the study participants had had a BCG vaccination, and half had a positive TST result. No differences were observed between atopic patients with high/low tuberculosis scores and CD14 genotypes in terms of atopic phenotypes, allergen sensitization, and levels of total IgE, sCD14, and IFN-gamma. However, the frequency of asthma was higher in atopic patients with a high tuberculosis score and was not associated with CD14 genotypes. Eosinophil counts in blood were higher in atopic patients with a high tuberculosis score and CC+CT genotypes. Conclusions: These results suggest that the C allele of the CD14-159C/T polymorphism has a marked effect on eosinophil levels in atopic patients with increased exposure to tuberculosis. In addition, the degree of exposure to tuberculosis in atopic patients may modify the development of asthma.
  • [ X ]
    Öğe
    Is CD14-159C/T gene polymorphism in atopy associated with tuberculosis or with hygiene hypothesis?
    (Wiley-Blackwell, 2010) Kavut, Baççıoğlu A.; Kalpaklıoğlu, F.; Birben, E.; Kalkan, Koca, I
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