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    Neopterin levels in nonreplicative HBV carriers
    (Elsevier Sci Ireland Ltd, 2002) Kilic, D.; Boyunaga, H.; Kaygusuz, S.; Akgul, E.O.; Al Rashed, M.; Kenar, L.; Kutluay, T.
    The aim of this study was to determine the existence of immune activation by measuring neopterin in HBV (Hepatitis B virus) carriers with viral load (HBV DNA) less than 5 pg/ml. Forty-three subjects and 56 healthy controls were included in the study. Neopterin levels of were compared. ALT and ALP levels in one patient and AST levels in two patients were found minimally higher than upper limit, and GGT levels were within the reference range in all patients. Neopterin levels in the patient group and in the controls were 159.97 +/- 13.39 and 84.10 +/- 11.45 nmol/l, respectively (P < 0.0001). The difference between the two groups was statistically significant (P < 0.0001). In conclusion, the increased neopterin levels of HBV carriers might be the indicators of the effect of cellular immunity. This increase might also implicate a background inflammation based on mainly cellular immunity that exists within the liver. (C) 2002 Elsevier Science B.V. All rights reserved.
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    A new inflammatory marker in overweight patients: triggering receptor expressed on myeloid cells-1
    (COMENIUS UNIV, 2020) Cifci, A.; Ceylan, Durmaz S.; Oklu, K.; Gungunes, A.; Katar, D.; Karahan, I; Boyunaga, H.
    BACKGROUND: Triggering receptor expressed on myeloid cells 1 (TREM-1) is secreted by phagocytes in adipose tissue and it also upregulates the expression of genes involved in the inflammatory response and atherosclerotic conditions. This study was aimed to investigate the serum TREM-1 levels in overweight patients. METHODS: Twenty-eight subjects in the overweight group (OG) and 20 age-matched healthy subjects in the control group (CG) (BMI 27.6 +/- 1.2 vs 23.1 +/- 2.17 kg/m(2), respectively, p< 0.001) were included in the study. The serum sTREM-1 level was measured by ELISA. The homeostasis model assessment score (HOMA-IR) was also calculated. RESULTS: The mean TREM-1 levels were significantly higher in OG than in CG (407.3 +/- 323.7 vs 150.3 +/- 152.7 pg/mL, respectively, p< 0.001). The HOMA-IR score was also significantly higher in OG than in CG (3.42 +/- 3.63 vs 2.77 +/- 1.61, respectively). A positive correlation was detected between TREM-1 and BMI (r= 0.318, p= 0.028). CONCLUSIONS: This study mainly demonstrated that a high serum TREM-1 level might be an early inflammatory marker in overweight patients. We found that TREM-1 might be associated with BMI in overweight patients regardless of insulin resistance (Tab. 1, Ref. 21). Text in PDF www.elis.sk.
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    A research on the level of urine neopterin to see if it may provide a vital clue for a provisional diagnosis of breast cancer in menopausal women
    (Elsevier Ireland Ltd, 2004) Bayram, M.; Bayram, O.; Boyunaga, H.; Özer, G.
    Objectives: To search the relation between the level of neopterin in urine and breast cancer developed in menopause. Methods: In this study, urine samples were collected from randomly selected menopausal and post-menopausal women who attended hospital, and from a control group. The participants were classified into two representative sample groups and a control group; 1st group: 30 menopausal and post-menopausal women whose ages varied from 45 to 80 and who suffered from breast cancer but had no viral infections, chronic inflammatory diseases and smoking habit; 2nd group: 30 menopausal and post-menopausal women aged between 48 and 63 with no complaint of any type of tumors, viral infections or chronic inflammatory diseases and with no smoking habit; 3rd group: A control group with 20 women aged between 20 and 28, who did not take part in sexual activities yet, and had no complaint of any type of tumors, viral infections or chronic inflammatory diseases and had no smoking habit. Urinalysis was carried out for each sample in order to measure the level of neopterin. Results: The mathematical results of neopterin levels for the groups showed that group I was significantly higher than group 11 and III (P = 0.0001); group H was significantly higher than group III (P = 0.003). Conclusions: If the results of this study were not confounded by another factor, then can we deduce that this relationship can be used as a risk factor that should warrent further investigation of breast cancer during the care and treatment of menopausal women. (C) 2004 Elsevier Ireland Ltd. All rights reserved.