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Öğe BCL-2-related apoptosis markers in cutaneous human papillomavirus-associated lesions(Lippincott Williams & Wilkins, 2004) Erkek, E; Bozdogan, O; Atasoy, P; Birol, A; Kocak, MBackground: Human papilloma virus (HPV) is an etiological agent in benign and malignant epithelial tumors. Resistance to apoptotic stimuli by viral strategies represents an immunologic escape mechanism during virus-induced tumor development and is critical for efficient replication of the virus. Objective: The aim of the present study was to investigate a role of bcl-family proteins in the anti-apoptotic pathways modulated by low-risk HPVs in the development of benign HPV-associated cutaneous tumors. Methods: Forty lesional biopsy specimens from HPV-associated cutaneous lesions and 11 non-lesional control skin biopsies were studied by immunohistochemical analysis for the differential expressions of HPV antigens, the pro-apoptotic bax protein, and the antiapoptotic bcl-2 and bcl-x proteins. Results: Compared with the normal epidermis, bcl-2 and bcl-x expression were significantly reduced in the lesional epidermis. Bax was expressed in HPV-associated cutaneous lesions, although the expression did not reveal a significant deviation from that in normal skin. Conclusion: These findings indicate a discordant expression of bcl2/ bcl-x and bax proteins in HPV-associated skin lesions and suggest that low-risk HPVs mediate other pathways that bypass the action of anti-apoptotic bcl-2 and bcl-x proteins. The presence of bax expression with a prominent decrease in bcl-2/ bax ratio and the lack of massive apoptosis in HPV-associated benign epithelial lesions may imply that interference with the pro-apoptotic proteins of bcl-family may constitute one of the several mechanisms mediated by HPV oncoproteins for the suppression of apoptotic process.Öğe BCL2 expression and its correlation with neuroendocrine differentiation in colon carcinomas(Pensiero Scientifico Editor, 2004) Atasoy, P; Bozdogan, O; Ozturk, S; Ensari, AAims and background: In this study we investigated the association between BCL2 expression and neuroendocrine differentiation in tubular adenomas and colon carcinomas. We also evaluated the prognostic significance of BCL2 expression and neuroendocrine differentiation in the carcinoma group. Methods: Forty-eight colon carcinomas and twelve tubular adenomas were stained immunohistochemically with BCL2 and chromogranin A (CgA). Staining patterns were scored semi-quantitatively and correlated with tumor type, tumor grade, Dukes stage, and survival time. Results: BCL2 expression was detected in 7 of 12 (58.3%) adenomas and 37 of 48 (77.0%) carcinomas. In normal mucosa we observed positive staining only in the basal portions of the crypts. However, diffuse positivity was observed in the adenomas and carcinomas. Carcinomas had significantly higher BCL2 scores than the normal group, but we did not observe any significant differences either between the adenoma and carcinoma group or between the adenoma and normal group. BCL2 scores were higher in stage B than in stage C tumors, and in adenocarcinomas than in mucinous carcinomas. CgA positivity was observed in 24 of 48 (50%) carcinomas. It was not detected in adenomas. We did not find a significant correlation between CgA expression and any of the clinicopathological parameters. Conclusion: On consecutive sections BCL2 and CgA positivity closely paralleled each other and a significant positive correlation was observed between CgA and BCL2 expression. These findings suggest a close association between BCL2 expression and neuroendocrine differentiation and indicate that BCL2 may be involved in neuroendocrine differentiation in addition to its role in protecting cells from apoptosis.Öğe Infantile myofibromatosis in a newborn: a case report(Turkish J Pediatrics, 2003) Caglayan, F; Cakmak, M; Bozdogan, O; Abasiyanik, FInfantile myofibromatosis presents as a firm, nodular mass in soft tissues, muscles, or visceras which can be solitary or multicentric, and it may regress spontaneously. We present a one-day-old boy who was admitted to the hospital for two masses, with one below the umbilicus that looked like a hemangiomatous structure and the other in the abdominal skin as a subcutaneous nodule. There was no intraabdominal involvement, and both of the masses were resected at 10 days of life. The one-year follow-up was uneventful.Öğe Juvenile subcorneal pustular dermatosis: A case report(Blackwell Publishing Inc, 2003) Kocak, M; Birol, A; Erkek, E; Bozdogan, O; Atasoy, PSubcorneal pustular dermatosis is a chronic, relapsing, pustular dermatosis that usually develops in elderly women. It is rarely seen in childhood and adolescence. The hallmark of the disease is formation of a subcorneal pustule detected on histopathologic examination. Herein we present a 13-year-old girl diagnosed with subcorneal pustular dermatosis based on the typical clinical and histologic findings. Direct and indirect immunofluorescence and serum protein electrophoresis had negative results. The patient partially recovered after 5 weeks of treatment consisting of oral dapsone and a topical steroid ointment.Öğe Kimura's disease in a Caucasian male treated with cyclosporine(Blackwell Publishing, 2005) Birol, A; Bozdogan, O; Keles, H; Kazkayasi, M; Bagci, Y; Kara, S; Kocak, M…Öğe Pigmented terminal hair cysts within an intradermal melanocytic naevus(European Acad Dermatology & Venereology, 2003) Erkek, E; Bozdogan, OThe combination of melanocytic naevi and cysts of adnexal or epithelial origin has been described previously. Herein we describe a case of intradermal melanocytic naevus containing pigmented terminal hair cysts, a rare variant of epithelial cysts. Our observation suggests that pigmented follicular cysts and combined cystic-melanocytic lesions may be attributed to follicular occlusion.Öğe Torsion of an epididymal cyst(Wiley, 2004) Yilmaz, E; Batislam, E; Bozdogan, O; Basar, H; Basar, MMTorsion of an epididymal cyst is a very rare condition. We present a case of torsion of an epididymal cyst in a 13-year-old boy. The patient presented with acute scrotal pain. Scrotal ultrasonography showed a 38 x 35 x 30 mm fluid-filled mass within the caput of the left epididymis. Histologically, the cells of the epididymal duct were necrotic. To our knowledge, this is the second case report in the literature.
