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    Effect of ondansetron for preventing of ovarian hyperstimulation syndrome: in an experimental rat model
    (Taylor & Francis Ltd, 2022) Bakirci, Suekrue; Sagsoez, Nevin; Devrim, Tuba; Sahin, Yasar; Bulanik, Murat; Goezueyukari, Hilal
    Objective: Ovarian hyperstimulation syndrome is an iatrogenic condition that occurs in the treatment of infertility. There is no specific treatment available for OHSS. Cabergoline is a dopamine receptor 2 agonist and VEGF-VEGF2 receptor antagonist . Recently, cabergoline has been widely used to prevent the development of OHSS and reduce its severity Serotonin is known as a neurotransmitter and thought to have a role in the mechanism of angiogenesis and in signaling in endothelial cells. Serotonin is said to have similar effects to VEGF . Ondansetron is Selective Serotonin (5-HT3) Receptor Antagonist . It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. In the clinical practice today, there is no choice other than cabergoline, to prevent occurrence and reduce severity of OHSS, and sometimes its effects are limited. Methods: In our study, we compared the effect of cabergoline and ondansetron. 32 immature rats were used and the OHSS model was created. Parameters such as hematocrit value , ovarian size, the number of follicles in the ovary, endometrial capillary congestion and thickness values were evaluated and compared. Results: As a result, in our study, it was seen that ondansetron was effective on OHSS in many parameters. It is thought to be as effective as cabergoline. When we look at the literature, this is the first study in which ondansetron was evaluated for this purpose. It would be good to show this effect of ondansetron with other studies.
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    The Effect of Varenicline on The Ovarian Follicle and Hormones, and Endometrial Thickness In An Experimental Model
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Bulanik, Murat; Sagsoz, Nevin; Bakirci, Şükrü; Yeral, Mahmut Ilkin; Atasoy, Pinar; Boyunaga, Hakan
    It was aimed to evaluate the histological, biochemical, and hormonal changes in the reproduct ive system of varenicline exposed female rats in an experimental model. Forty female rats were randomized into 4 groups. (1) Control group (n = 10); (2) Smoking group (smoking exposure 30 minutes twice a day) (n = 8); (3) Varenicline group (1 ml/kg); (4) Smoking+Varenicline (varenicline treatment (1 ml/kg) after smoking exposure (30 minutes twice a day). After the experiment, ovarian follicle count and endometrial thickness were examined; biochemical hormones-include Anti-mullerian hormone-and free oxygen radical levels were calculated. AMH levels were significantly lower in group 4 than in group 1 (p = 0.049). Group 2 and group 3 were significantly lower than group 1 (p = 0.038, p = 0.045, respectively). There was no statistically significant difference in endometrial thickness and free oxygen radical levels between the groups (p>0.05). We found that varenicline is related to reduced AMH and PRMF levels. The difference in endometrial thickness between the groups was not detected. These findings show that varenicline may harm ovarian functions. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.