Yazar "Caglayan, F" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Öğe Effect of extratesticular hematoma on testicular blood flow and the histology of the testis and dartos fascia - An experimental study(Karger, 2004) Caglayan, F; Cakmak, M; Karadeniz, Y; Atasoy, P; Eroglu, E; Apan, AIntroduction: Hematoma is a common complication of inguinoscrotal surgery in childhood. We aimed to identify the possible effects of extratesticular hematoma on blood flow and the histology of testes in the early period. Also, the dartos tissue was evaluated histologically. Materials and Methods: Unilateral extratesticular hematoma was created in 12 New Zealand rabbits. Parenchyma of the testes and scrotum walls was evaluated by B-mode ultrasound and the spectrum from the intratesticular vessels was obtained by color Doppler ultrasound on days 1, 7 and 15 of the procedure. Testes and scrotal walls were removed at the end of the study for histologic evaluation. Results: There were no significant pathologic findings in the evaluation of the parenchyma and hemodynamia of the testes on days 1, 7 and 15. A well-organized but continuing hematoma was observed on day 15. Increased fibroblastic activity, dense inflammatory cells, necrotic areas and destruction of the muscular layer were observed at pathologic evaluation of the scrotum. Conclusions: Extratesticular hematoma has no effect on testicular histology and hemodynamia in the early period. Pathologic evaluation revealed fibrosis of the dartos fascia at the end of the second week. Destruction and fibrosis of this tissue may have an adverse effect on spermatogenesis by altering thermoregulation. Copyright (C) 2004 S. Karger AG, Basel.Öğe The effect of ischemia reperfusion on intestinal contractility regulated by the nitrergic system(Scientific Technical Research Council Turkey, 2004) Caglayan, F; Sahin, A; Gunel, E; Cakmak, M; Caglayan, OBecause of the interaction between nitric oxide (NO) and the superoxide anion radical, the effect of ischemia-reperfusion on intestinal contractility regulated by the nitrergic system was investigated in the present study. The study was performed on 3 groups of rabbits: group 1, ischemia; group 2, ischemia and 1 h of reperfusion; group 3, ischemia and 24 h of reperfusion. Tissue samples were obtained from ischemic, ischemia-reperfused and adjacent uninjured intestines as study and control samples. The effects of atropine, tetrodotoxin, L-NAME and L-arginine on the intestinal response to electrical field stimulation (EFS) were investigated. Guanethidine was used to minimize adrenergic activity. Tetrodotoxin and atropine prevented contractions. L-NAME enhanced the responses to EFS in all tissue samples except for the study tissue of group 2, and L-arginine reversed this contraction elevation. Group 2 study tissue response was as high as 170% of that of the control tissue in standard Krebs-Henseleit solution, and no change was seen on this level with L-NAME and L-arginine addition. The effects of tetrodotoxin and atropine revealed that EFS affects via the cholinergic neuronal system. Ischemia reperfusion affects intestinal contractility, especially in the early phases of reperfusion. In the light of the increased response to EFS and insensitivity to L-NAME and L-arginine of the affected tissue during this period it was thought that the nitrergic system is considerably affected by ischemia reperfusion. Excessive production of superoxide anion radicals or reversible inhibition of nitric oxide synthase may be the cause of this.Öğe Infantile myofibromatosis in a newborn: a case report(Turkish J Pediatrics, 2003) Caglayan, F; Cakmak, M; Bozdogan, O; Abasiyanik, FInfantile myofibromatosis presents as a firm, nodular mass in soft tissues, muscles, or visceras which can be solitary or multicentric, and it may regress spontaneously. We present a one-day-old boy who was admitted to the hospital for two masses, with one below the umbilicus that looked like a hemangiomatous structure and the other in the abdominal skin as a subcutaneous nodule. There was no intraabdominal involvement, and both of the masses were resected at 10 days of life. The one-year follow-up was uneventful.Öğe Protective effects of trapidil in lung after abdominal aorta induced ischemia-reperfusion injury: an experimental study(Springer, 2005) Somuncu, S; Cakmak, M; Erdogan, S; Caglayan, O; Caglayan, F; Akman, H; Kaya, MWe aimed to investigate the protective effects of trapidil after the occlusion of abdominal aorta and the reperfusion injury in lung. Eighteen New Zealand albino rabbits were used in the study. In six animals [group 1, ischemia-reperfusion (IR) group], the abdominal aorta was exposed and a microvascular clamp was placed in the infrarenal abdominal aorta for 60 min. After the ischemic period, the microvascular clamp was removed and reperfusion was provided for 2 h. After the reperfusion period, the lungs were removed carefully and specimens were prepared for histopathological and biochemical studies in appropriate conditions. In group 2 (study group), trapidil (Rocarnal, Rentschler-UCB GmbH, Kerpen, Germany) was administered intraperitoneally as a single dose 1 h prior to trial, the IR procedure was performed and lung specimens were prepared similar to group 1. In group 3 (sham group), the infrarenal abdominal aorta was exposed and lung specimens were prepared for histopathological and biochemical studies at the end of the study. Histopathological changes, malondialdehyde (MDA), nitric oxide (NO) and total sulfhydryl group (T-SH) levels were evaluated. There was a statistical difference between the IR group and study group regarding NO and MDA levels (P < 0.05 and P < 0.01, respectively), but this was not detected between the IR group and the sham group (P > 0.05). There was no statistical difference among the three groups regarding T-SH levels (P > 0.05). While a statistical difference was found between the sham group and study group in the NO level (P < 0.05), no statistical difference was found in the MDA level (P > 0.05). There was a statistical difference in interstitial edema, PMN infiltration and hemorrhage scores among the groups (P < 0.05). There was a statistical difference between the IR group and study group in PMN infiltration (P < 0.05), but this was not detected between the groups in interstitial edema and hemorrhage scores (P > 0.05). There was a statistical difference between IR group and sham group in interstitial edema, PMN infiltration and hemorrhage scores (P < 0.05). Statistical difference was found between the sham group and study group in interstitial edema and hemorrhage scores (P < 0.05), but not in PMN infiltration (P > 0.05). Conclusions: Infrarenal abdominal aortic occlusion and reperfusion causes lung injury. We conclude that trapidil has preventive effects in the lung tissue after IR injury.
