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    Chromosomal aberrations induced by radiotherapy in lymphocytes from patients with lung cancer
    (Triveni Enterprises, 2009) Cavuşoğlu, Kültigin; Arıca, Şükran Çakır; Bökesoy, Işık; Kurtman, Cengiz
    In this study we tried to define incidence and types of chromosomal aberrations (CAs) caused by radiotherapy (RT) in circulating lymphocytes from patients with lung cancer. For this purpose, we used cumulative dose-effect relationship, and correlate these data with statistical parameters. CAs were evaluated in terms of chromosome break, dicentric, ring and chromosome gap. Abnormal metaphase number (AMN) was also calculated. Chromosome studies were carried out in peripheral blood lymphocytes of 20 cancer patients receiving RT Patients were treated with 10 Gy of gamma (gamma) radiation during five wk(s). In all patients, a significant increase in AMN and frequency of CAs (e.g. chromosome break, dicentric, ring and chromosome gap) observed during the RT depend on cumulative radiation dose when compared to before RT and this increase was statistically significant (p<0.05). The highest CAs frequency was observed at the end of fifth wk. Among the CAs, chromosome breaks have a high incidence. But no CAs and abnormal metaphase was observed in lymphocytes before RT The present study showed that RT possess a significant effect in increasing of CAs and chromosome break, dicentric, ring and chromosome gap are very sensitive and useful biomarkers in the study of this effect. In other words, these CAs may be used as possible fingerprints of RT.
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    Öğe
    Effects of exposure to heavy metal ions and gamma radiation on some biochemical parameters in mice
    (Parlar Scientific Publications (P S P), 2009) Cavuşoğlu, Kültigin; Yalçın, Emine; Atmaca, H. Tarık
    The present study was carried out to evaluate the effects of Pb and Hg ions, as well as (gamma)-radiation on serum parameters in Swiss albino mice. For this purpose, we determined the concentrations of albumin (ALB), total bilirubin (TB), as well as the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) enzymes which are, especially, markers of liver injury. The study was carried out on 80 male mice. The animals were randomly divided into 4 groups. The control group (group I) mice were treated with tap water, whereas mice in group II 20 ppm Pb and those in group III 20 ppm Hg was orally given, and mice in group IV were treated with 10 Gy gamma-radiation for consecutive 14 days. The blood samples were collected from the mice at the end of the 7(th) and 14(th) day to determine the effect of exposure time on serum parameters. The AST, ALT, ALP and GGT levels, and the ALB and TB concentrations were determined by using an autoanalyzer. Serum analysis results indicated that there was an alteration in enzyme levels and concentrations of ALB and TB depending on exposure time in all treated groups when compared to controls. The levels of AST, ALT, ALP and GGT significantly increased in serum of mice in all treatment groups at. the end of 7 days, but enzyme levels showed a decrease at the end of 14(th) day. Even so, this decrease was still higher when compared to that of control and 7(th) day. Moreover, enzyme levels were higher in mice exposed to gamma-radiation than in Hg and Pb-treated ones, and difference was statistically significant (P<0.05). Besides, an increase in the concentration of TB and a decrease in the concentration of ALB were observed during exposure. All these findings were also supported by histopathology of liver and kidney tissues. These results indicated that AST, ALT, ALP, GGT, ALB and TB parameters are very sensitive and useful biomarkers for the evaluation of the harmful effects of various agents, such as heavy metal ions and gamma-radiation.