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  • Küçük Resim
    Öğe
    Bcl-2-related proteins, (alpha)-smooth muscle actin and amyloid deposits in aggressive and non-aggressive basal cell carcinomas
    (Taylor & Francis As, 2002) Bozdoğan, Ö.; Erkek, E.; Atasoy, P.; Koçak, M.; Birol, A.; Caydere, M.
    Aberrant expression of bcl-gene products has been implicated in the development of non-melanoma skin cancers. Recently, altered expression of alpha-smooth muscle actin has been proposed as predictive of tumour behaviour in basal cell carcinomas. The purpose of this study was to compare the aggressive and non-aggressive basal cell carcinomas in terms of bcl-gene products and alpha-smooth muscle actin expression. Fifty excisional biopsy samples were studied by immunohistochemical technique for the differential expressions of bcl-2, bax, bcl-x and alpha-smooth muscle actin. Bcl-2, bcl-x and bax were expressed in 34 (68%), 38 (76%) and 41 (82%) specimens, respectively. Immunoreactivity for alpha-smooth muscle actin was noted both in tumour nests (64%) and within the stroma (54%). There was a significant difference between aggressive and non-aggressive basal cell carcinomas in terms of bcl-2 and stromal alpha-smooth muscle actin immunoreactivity. Non-aggressive basal cell carcinomas display a concordant expression of bcl-family proteins, whereas aggressive tumours reveal a discordant pattern. An increased expression of stromal alpha-smooth muscle actin with a concomitant decrease or loss of bcl-2 expression may be highly suggestive of aggressiveness in basal cell carcinoma.
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    Öğe
    Nocardia farcinica brain abscess: a case report and review of the literature
    (Sociedad Luso-Espanola Neurocirugia, 2004) Sabuncuoglu, H.; Açikgöz, Z.C.; Caydere, M.; Ustun, H.; Keskil, I.S.
    Nocardia infection is not rare as generally been assumed and its mortality rate is high. It is isolated from plants and soil in most regions of the worid. The hosts usually have predisposing conditions and the infection is acquired through the respiratory tract or skin. Nocardial organisms have a tendency to disseminate hematogenously from the primary site of infection to brain, kidney, joints, bones and eyes. Sulfonamides are preferred empirically for the treatment. Because of high relapse rates, the treatment must be continued for 12 months. In nocardia farcinica infection, the characteristic resistance pattern to cephalosporines must be kept in mind. In this article, a rare case of nocardia farcinica infection with a solitary cerebral abscess is presented and the literature is reviewed.