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Öğe Bioactivity of Centaurea persica boiss. (Asteraceae)(Inst Bioloska Istrazivanja Sinisa Stankovic, 2012) Sarker, Satyajit D.; Nahar, Lutfun; Gujja, Srikanth; Begum, Shazi; Celik, SezginThe free-radical-scavenging property, antibacterial activity and brine shrimp toxicity of petroleum ether (PE), dichloromethane (DCM) and methanol (MeOH) extracts of Centaurea persica, a Turkish medicinal plant, were assessed using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the resazurin microtiter plate based assay, and the brine shrimp lethality assay, respectively. Additionally, the disc diffusion assay was also used to assess antibacterial activity. Only the MeOH extract of C. persica exhibited a significant free-radical-scavenging property in the DPPH assay, with an RC50 value of 0.025 mg/mL. However, in the TLC-based qualitative assay, petroleum ether and DCM extracts showed an extremely low level of free-radical-scavenging property. Among the solid-phase extraction fractions of the MeOH extract, the fractions eluted with 60% and 80% MeOH in water exhibited the highest level of free-radical-scavenging activity (RC50 = 0.010 and 0.015 mg/mL, respectively). While DCM extract showed reasonable antibacterial activity against five out of the nine test strains both in the disc diffusion assay and in the resazurin assay, the MeOH extract was highly active against both Escherichia coli and ampicillin-resistant E. coli strains. Among the solid-phase extraction fractions of the MeOH extract, fractions eluted with 80% MeOH in water and 100% MeOH displayed significant antibacterial potencies against both E. coli species. None of the extracts showed any significant toxicity towards brine shrimps (LD50 = >1.00 mg/mL).Öğe Canonical correlation analysis for studying the relationship between the basic morphological and some soil chemical characteristics of Centaurea mucronifera DC. (Asteraceae)(Asian Journal Of Chemistry, 2008) Celik, Sezgin; Yuecel, Ersin; Mendes, Mehmet; Tug, G. Nilhan; Oeztuerk, MuenirThis aim of this study was to investigate the relationship between the basic morphological features and some soil chemical characteristics in order to enlighten the differentiation in the Centaurea mucronifera populations distributed at 16 different places under varying environmental conditions. For this purpose method of Canonical correlation analysis (CCA) was used. The results revealed that morphological features like length of terminal leaves (Y3), length of capitula (Y4), length of involucrum (Y5) and length of achen (Y6) are affected positively by N (X6) and Ca2+ (X7) in the soil but the length of plant (Y1), length of basal leaves (Y2) and length of pappus (Y7) are affected negatively.Öğe Carolina poplar (Populus x canadensis Moench) as a biomonitor of trace elements in Black sea region of Turkey(Triveni Enterprises, 2010) Celik, Sehnaz; Yucel, Ersin; Celik, Sezgin; Gucel, Salih; Ozturk, MunirIn this study, the leaves, bark and the soil supporting Populus x canadensis Moench were tested as a possible biomonitor of trace element pollution in the Middle Black Sea region of Turkey The investigations were carried out at 23 sites. The leaves, bark and soil were analyzed for Pb++, Cd++, Fe++, Cu++ and Zn++ contents. The values of Pb++, Cd++, Fe++, Cu++ and Zn++ in the leaves varied between 14.5-40.0, 0.5-1.5, 135-486, 5.0-14.0 and 43-246 ppm, respectively. In the bark the values were between 15.5-36.5 (Pb++), 1.5-2.0 (Cd++), 39-575 (Fe++), 5.0-14.0 (Cu++) and 40.0-1468 ppm (Zn++), whereas in the soil values forPb** were 1.0-4.1 ppm, for Cd++ 0.2 ppm, for Fe++ 0.6-1.8 ppm, for Cu++ 0.1-0.9 ppm and for Zn++ 0.1-1.9 ppm. A positive correlation was found between traffic density and the amount of Pb++, Fe++ and Cu++ in leaves, while a negative correlation was documented for Cd++ and Zn++. In the bark samples there was a positive correlation between traffic density and Pb++, and a negative one with Cd++, Fe++, Cu++ and Zn++. Apositive correlation was determined between traffic density and the amount of Pb++, Fe++, Cu++ and Zn++ in soil. However, the amount of Cd++ was 0.2 ppm and no relationship between Cd++ and traffic density was observed.Öğe Conservation strategy of critical endemic Centaurea hausknetchii Boiss. (Section : Cyanoroides) and effects of different salt, nitrate and acid concentrations on the germination of seeds(Asian Journal Of Chemistry, 2008) Celik, Sezgin; Yucel, ErsinCentaurea hausknetchii is a local endemic species growing only in the Nemrut Mountain Historical National Park in the Southeast Anatolian region of Turkey. It grows in three small areas of this mountain and all these areas are under heavy grazing pressure. The germination behaviour of the seeds was studied and for this purpose seeds were left under two different photoperiods (8 h light-16 h darkness and 16 h light-8 h darkness) and treated with different concentratios of NaCl, KNO(3), H(2)SO(4) and HCl solutions. There was no germination in 3 % NaCl, 1-3 % KNO(3), 1-3 % H(2)SO(4) and 2-3 % HCl concentrations in each photoperiod. According to the univariate variance analysis of germination Lest results, germination media with different salts, nitrate and acid concentration (e.g., 0.5 %,1.0 %, 2.0 % NaCl; 0.5 %.1.0 %.2.0 %,3.0 % KNO(3); 0.5 % H(2)SO(4); 0.5 %, 1.0 % HCl) under different photoperiods (8 h light-16 h darkness and 16 h light-8 h darkness and 24 h light) and control have been investigated. The photoperiod and photo period-treatment interaction had a significant impact on the germination percentage and rate (p < 0.05). C. hausknetchii is in the critically endangered category (CR) in the IUCN 2000 Red Data Book. The habitat characteristics of the distribution sites were thus investigated, vegetative growth behaviour followed and interrelations between the increase and spread of populations recorded. The factors effecting the productivity were determined. This report will be helpful in the population biology studies and development of alternatives for effective protection programme.Öğe Ethnoecology of poisonous plants of Turkey and Northern Cyprus(Pakistan Botanical Soc, 2008) Ozturk, Munir; Uysal, Ismet; Guecel, Salih; Mert, Tuba; Akcicek, Eren; Celik, SezginInterest in plants is increasing and much work is being carried out these days on their multipurpose uses. A great impetus has been given to this during the last 3 decades. Several publications have been made by different investigators. Large number of naturally growing plants are collected and sold at the markets. Nearly 500 plants are used for primary health care in Turkey and a 23 in Cyprus. However, not much is known about the poisonous plants. Some of these are toxic and others cause reaction. Plant poisoning lies around 6%, rurals suffer more from the consumption of naturally growing plants as compared to urban dwellers. One has to be very cautious before using these plants as the plants used for the purpose of treatment of diseases as a whole or parts thereof or consumed by the public directly could prove dangerous for the health. This paper describes ethnoecological aspects of the widely distributed major poisonous plants in Turkey and Northern Cyprus which can prove fatal if used unknowingly. Major applications and active constituents of plant taxa are outlined.Öğe Morphological variation and plant nutrients effects of two taxonomically distant Centaurea L. species(Asian Journal Of Chemistry, 2008) Celik, Sezgin; Oezkan, Kuersad; Yuecel, ErsinIn this study, the influence of habitat on Centaurea mucronifera and C pyrrohoplephara, whose morphological variants show obvious differences, spreading on calcareous soils of Mediterranean, Central and East Anatolia were examined. C. mucronifera and C pyrrohoplephara are both perennials and have the height between 4 and 50 cm. The influence of nutrition elements in plant and physical and chemical properties of soils on morphological variations of C mucronifera and C. pyrrohoplephara were determined with the models that have the highest explanation portion without multiple linkage problems on the base of model and variant and their relationships were investigated by using Stepwise Regression Analysis. It was found that there was a univariate independent model, showing the positive contribution of phosphorus content of root on plant nutrition element content and root length and for sodium content of stem on length of basal leaf and outer whorl of pappus in C mucronifera. In C pyrrohoplephara, between morphological characteristics and plant nutrition elements, on the base of model and variant, models having highest explanation portion without multiple relation problems were defined for variants of root length, plant length, width of basal leaf, capitula and involucrum, achene length, pappus inner whorl length. There was not any defined model determining the relationships between physical and chemical properties of soils and length and width of terminal leaf(p < 0.05). According to these results, it was found that, for C.mucronifera and C pyrrohoplephera, physical and chemical properties of soils have an important role on the morphological structure of these species and there could be relationships between morphological structures of these taxa and the ratios of the variants of these plant nutrition element contents and also the influence of plant nutrition elements on the morphological differentiations of these species is relatively low (p < 0.05).Öğe Morphology, anatomy, ecology and palynology of two Centaurea species from Turkey(Bangladesh Botanical Soc, 2008) Celik, Sezgin; Uysal, Ismet; Menemen, YusufCentaurea L. sect. Plosimopappa, a local endemic group in the Mediterranean and South East Anatolia, is represented by only two species, namely C. ptosimopappa Hayek and C. ptosimopappoides Wagenitz in Turkey. Both these species show a very restricted distribution as serpentine habitat indicators and are recorded as vulnerable. Present study was carried out to enlighten the morphological, anatomical and ecological features of these two species in detail. The structure of achene, indumentum and pollen grains were investigated by using Scanning Electron Microscope (SEM). The capitulum, involucre and leaf structure of these two species are rather similar, but their achenes and pollen grains differ from each other. In C. ptosimopappa pollen spinules are densely distributed but in C. ptosimopappoides they are sparsely distributed. The achenes are obovate in C. ptosimopappa and rectangular in C. ptosimopappoides. C. ptosimopappa is a scrub species but C. ptosimopappoides is a subscrub species. A negative relation in terms of the proportion of sand to silt content of the soil and positive relation between the percentage of CaCo3 and pH was observed for C. ptosimopappa (p < 0.05). A negative relation in terms of the proportion of sand to silt content of the soil was observed in C. ptosimopappoides (p < 0.01).Öğe An Overview Of The Geobotanical Structure Of Turkish Pinus Sylvestris And Carpinus Betulus Forests(Pakistan Botanical Soc, 2008) Gucel, Salih; Özkan, Kürşat; Celik, Sezgin; Yücel, Ersin; Öztuerk, MünirPinus L and Carpinus L. are the two widely distributed genera of gymnosperms being represented by 80 and 170 species respectively. The former has 5 species in Turkey and latter 2 species namely; P.pinea, P.halepensis, P.brutia, P.sylvestris, P.nigra ssp.pallasiana, Carpinus betulus and C.orientalis. In this paper an attempt has been made to present all overview of the geobotanical structure of Pinus sylvestris L. and Carpinus betulus L. in Turkey. Out of 20.2 million hectares of forests in Turkey yellow pine covers nearly 1.3 million ha and hornbeam species around 10 thousand ha. The forests of P. sylvestris are found in North, Northeast Anatolia, oil Murat Mountains around Kutahya and C. betulus mainly in Thrace, Marmara, Black Sea and Inner Anatolia. P.sylvestris is represented by 9 associations;Pinus sylvestris-Vaccinum myrtillus, Pinus sylvestris - Daphne glomerata, Pinus sylvestis - Astragalus adzharicus, Pinus sylvestris-Lilium ciliatum, Pinus sylvestris-Daphne pontica, Pinus sylvestris-Populus tremula, Populo-Pinetum sylvestris, Pinus sylvestris-Orthilio secundo, Pinus sylvestris Llazica-Epimedium pinnatum subsp. colchicum, Triseto-Pinetum sylvestris. whereas C.betulus has only 6 associations Carpinus betulus-Scaligeria tripartita, Carpinus betulus-Acer campestre, Quercus petraea ssp. iberica-Carpinus betulus, Carpinus betulus-Quercus petrae ssp. iberica, Fagus orientalis-Carpinus betulus. P.sylvestris associations are floristically rich having 275 taxa as compared to C.betulus forests which embody only 121 taxa. The life form spectrum of P.sylvestris forests includes 146 chamaephytes, 44 hemicryptophytes, 40 phanerophytes, 28 cryptophytes and 17 therophytes, whereas C.betulus forests include 23 phanerophytes, 39 chamephytes, 36 hemicryptophytes,14 cryptophytes and 8 therophytes. Phytogeographically a major part of the taxa in P.sylvestris forests are Euro-Siberian elements (24.4%) followed by the Irano-Turanian (6.4%) and Mediterranean (1.4%). In C.betulus forests the distribution is as follows; Euro-Siberian-Euxine elements (83%) followed by Mediterranean (14%) and Irano-Turanian (3%). These observations stress the fact that geobotanically these forests prefer mainly high altitude moist habitats in the north and northeastern parts of Turkey.Öğe Plant species microendemism, rarity and conservation of pseudo - alpine zone of Kazdagi (Mt. Ida) national park - Turkey(Elsevier Science Bv, 2011) Ozturk, Munir; Uysal, Ismet; Karabacak, Ersin; Celik, SezginKazdag (Mt. Ida) forms a natural border between the Provinces of Canakkale and Balikesir in the north-western part of Turkey. It was declared as National Park in 1993 because of its rich plant cover, a restricted zone of Abies nordmanniana ssp. equi-trojani forest, natural beauty and mythology. The pseudo-alpine zone consists of 189 specific and infraspecific taxa of vascular plants. A total of 55 endemic taxa (29.10%) were recorded from this area. Out of these 22 (40%) taxa are restricted only to this area, and 5 taxa are non-endemic but rare in Turkey. In this paper, habitat characteristics, conservation strategies and management of these taxa are given. Our investigations revealed that, out of 55 taxa, 12 are critically endangered (CR), 10 endangered (EN), 11 vulnerable (VU), 9 not threatened (NT) and 18 with lower risk (LC). Although Hieracium idae, Dianthus arpadianus var. trojanus, Minuartia garckeana and Paronychia sintenisii are recorded as data deficient (DD) category in IUCN criteria, these taxa are transferred to CR category. (C) 2011 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of The 2nd International Geography Symposium-Mediterranean EnvironmentÖğe Polymorphisms and Protein Expressions of Glutathione S-Transferase M1 and T1 in Non-Small Cell Lung Cancer(Turkish Pharmacists Assoc, 2017) Kilic, Murat; Ada, Ahmet Oguz; Oguztuzun, Serpil; Demirag, Funda; Celik, Sezgin; Bicakcioglu, Pinar; Iscan, MumtazObjectives: The deletion polymorphisms of glutathione S-transferase (GST) GSTM1 and GSTT1 genes result in the absence of the corresponding protein, which decreases the detoxification of carcinogens. Studies evaluating polymorphisms and protein expressions in the same patients are limited. Therefore, in this study, we aimed to investigate the association between polymorphisms and protein expressions of GSTM1 and GSTT1 in lung tissues of patients with non-small cell lung cancer (NSCLC). Materials and Methods: For protein expression and gene deletion studies, tumor and surrounding tumor free (normal) tissue of 33 patients with NSCLC were used. In paraffin-embedded tissues, immunohistochemistry was used to detect protein expressions, and multiplex polymerase chain reaction amplification was used to identify gene deletions. Results: GSTM1 and GSTT1 protein expressions were not detected in patients with GSTM1 and GSTT1 gene deletions, whereas protein expressions were detected in lung tissues of all patients carrying GSTM1 and GSTT1 genes. The protein expression level of GSTT1 was 2.0-fold higher in tumors of patients lacking GSTM1 genes than those with GSTM1 genes (p=0.018). Protein expression of GSTM1 was statistically higher in tumor tissues than in normal tissues of patients with GSTM1 genes (p=0.001). Conclusion: These results show that a) there is an association between gene deletions and protein expressions of GSTM1 and GSTT1 in patients with NSCLC, b) in the absence of GSTM1 genes, enhancement of expression of GSTT1 in tumors is likely to show that GSTT1 increases its capacity to detoxify the toxic electrophiles in tumors, and c) GSTM1 protein expression is higher in tumors compared with normal lung tissues of patients with NSCLC.Öğe Verbascum ergin-hamzaoglui (Scrophulariaceae), a new species from South Anatolia, Turkey(Tubitak Scientific & Technical Research Council Turkey, 2011) Karaveliogullari, Faik Ahmet; Celik, Sezgin; Baser, Birol; Yavru, AhterVerbascum ergin-hamzaoglui Karavel. sp. nova (Sect. Bothrosperma Murb.), is described for the first time to the scientific community from South Anatolia in Turkey. The diagnostic morphological characters of these new species and other closely related species (V. diversifolium Hochst. and V cymigerum Hub.-Mor.) are discussed. In addition, distribution maps of V ergin-hamzaoglui and its related species are provided. The pollen morphologies of 3 taxa belonging to Verbascum L. from the family Scrophulariaceae from Turkey were investigated using a light microscope (LM) and scanning electron microscope (SEM). This family's pollens show similarities to the eurypalynous family. The pollens of these taxa are generally of radial and isopolar symmetries. Pollen shape changes from subprolate to spheroidal. The shape of the aperture is tricolporate, sculpture is tectate, and ornamentation is reticulate. The seeds of this group are brown and are of oblong shape in V diversifolium and V cymigerum, while the shape is ovate in V ergin-hamzaoglui.Öğe Verbascum ozturkii (scrophulariaceae), a new species from East Anatolia, Turkey(Pakistan Botanical Soc, 2008) Veliogullari, Faik Ahmet Kara; Uzunhisarcikli, M. Erkan; Celik, SezginA new species Verbascum ozturkii Karavel., Uzunh. & S. Celik sp. nov. (Sect. Bothrosperma Murb.), has been described here. It was collected from East Anatolia in Turkey The species is related to V. oocarpum Murb. and thus a comparison was made. It differs from V. oocarpum Murb. Mainly in its hair Situation, basal leaves, inflorescence. pedicels, calyx. corolla, stamens and capsule features.
