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Öğe The Effect of Body Mass Index on the Clinical Course of Appendicitis in Children(Ortadogu Ad Pres & Publ Co, 2012) Aslan, Mustafa Kemal; Cesur, Ozkan; Soyer, Tutku; Hancerliogullari, Oymen; Turkmen, Feyza; Cakmak, MuratObjective: A retrospective study was performed to evaluate the effect of body mass index (BMI) on the clinical course of appendicitis in children. Material and Methods: Patients between 6 and 18 years of age, who had undergone appendectomy in the last 2 years, were evaluated for age, sex, BMI, time from the beginning of complaints to diagnosis, acute Or perforated appendicitis, duration of hospitalization and complications retrospectively. BMI was evaluated according to percentiles developed for Turkish children between 6 and 18 years of age. Patients with percentiles between 10 to 75 were accepted as the normal BMI group, lower than 10 was the low BMI group and more than 75 was assessed as the high BMI group. Results: Ninety-six patients were included in the study. The median age was 13 (min: 6, max:16) in the normal BMI group [n=37, male/female (M/F)=1.84], 12(6-16) in the low BMI group (n=38, M/F=1.53) and 9(6-15) in the high BMI group (n=21, M/F=3.2). The acute/perforated appendicitis ratios were 3.1, 2.8 and 1.3, respectively in the normal, low and high BMI groups. There was no significant difference between the groups regarding the time from the beginning of complaints to diagnosis and duration of hospitalization (p>0.05). Although complication rates showed no difference between the normal and low BMI groups, the high BMI group had a higher incidence of complications compared to the normal and low BMI groups (p=0.04 and p=0.018,respectively). The follow-up period of the patients were 2 months to 2 years and the most common complication was wound infection. Conclusion: Children with high BMI have higher complication rates during the clinical course of appendicitis compared to children with low and normal BMI.Öğe Effect of P/E-selectin blockage on antisperm antibody development and histopathological alterations in experimental orchitis(W B Saunders Co-Elsevier Inc, 2013) Cesur, Ozkan; Aslan, Mustafa Kemal; Ayva, Sebnem Kupana; Fedakar-Senyucel, Mine; Soyer, Tutku; Kisa, Ucler; Cakmak, MuratAim: This study aimed to evaluate the effect of P/E-selectin blockage on antisperm antibody (ASA) development and histopathological alterations in experimental orchitis. Materials and Methods: Thirty-six Wistar albino-type male rats weighing 100-150 g were included in the study. Rats were allocated into six groups (n = 6) including control (CG), sham (SG), orchitis (OG), antimicrobial treatment (AG), P/E-selectin blockage (PESG), and both antimicrobial and P/E-selectin treatment (TG) groups. In CG, serum samples were taken from the tail vein prior to the procedure and followed by extraction of both testes. In SG, 1 ml of saline solution was injected in testicular parenchyma. OG was obtained by injecting 0.1 ml 106 cfu/ml Escherichia coli (0: 6 strain) and 1 ml saline solution into the right testes. AG received ciprofloxacin (50 mg/kg/day) twice a day through gastrogavage 24 hours after generating orchitis. In PESG, P/E-selectin antibody (100 mu g) was administered intravenously via the tail vein 24 hours after the induction of orchitis. Finally, both ciprofloxacin and P/E-selectin antibody were administered in TG 24 hours after the induction of orchitis for 14 days. At the end of treatment, 1 ml of serum sample was obtained to evaluate the ASA, P-selectin and E-selectin levels. In order to evaluate spermatogenesis (Johnsen score) and testicular injury (Cosentino score), both testes were extracted at the end of the 14th day. Results: In orchitis-induced groups (OG, ATG, PSEG, TG), ASA levels were significantly increased at the 14th day when compared to SG (p < 0.05). In TG, ASA levels were decreased when compared to AG. However, similar alteration in ASA levels was not detected in PSEG (p > 0.05). In OG and AG, P-selectin levels were decreased at the 14th day when compared to levels observed on 0 day (p < 0.05). E-selectin levels on 0 day showed that each group had higher levels of E-selectin when compared to CG (p > 0.05). There was no significant difference regarding E-selectin when compared to CG (p > 0.05). No significant differences regarding E-selectin levels were detected on the 0th and 14th days between AG and CG (p > 0.05). When the Cosentino and Johnsen scores were compared among groups, TG and PSEG has decreased scores of Cosentino than OG on the right testicle (p < 0.05). In contrast, an increased Johnsen score was detected in TG and PSEG when compared to OG (p < 0/05). No significant difference was detected for both Cosentino and Johnsen scores on the left testicle (p > 0.05). There was no difference with regard to the right and left testicular injury in TG. In P/E-blocked groups, decreased histopathological alterations were observed in the contralateral testis. Conclusion: P/E-selectin blockage may reduce ASA production after orchitis when combined with antimicrobial treatment. P/E-selectin blockage not only has a protective effect on blood-testis barrier but also decreases the histopathological alterations in both the affected and contralateral testis. Histopathological parameters of spermatogenesis may also be prevented by P/E-selectin blockage in experimental orchitis. (C) 2013 Elsevier Inc. All rights reserved.Öğe Intrascrotal Extratesticular Neurofibroma as a Possible Cause of Failed Descent in Ipsilateral Testis(All India Inst Medical Sciences, 2012) Soyer, Tutku; Vargel, Ibrahim; Ayva, Sebnem; Cavusoglu, Tarik; Cesur, Ozkan; Bulbul, Selda; Cakmak, MuratIntrascrotal extratesticular neurofibromas (IEN) often originate from genitofemoral nerve (GFN) and present as a paratesticular mass. Synchronous presence of IEN and undescended testis has not been reported previously. A 12-year-old boy with neurocutaneous syndrome and congenital giant melanocytic nevi along with IEN and ipsilateral undescended testis is presented, to discuss the underlying pathophysiology of failed testicular descent in the presence of IEN.
