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Öğe Comparison of American and European Guidelines for the Management of Patients With Valvular Heart Disease(Elsevier Inc, 2023) Inanc, Ibrahim Halil; Cilingiroglu, Mehmet; Iliescu, Cezar; NInios, Vlasis; Matar, Fadi; Ates, Ismail; Toutouzas, KonstantinosThis review compares the recommendations of the recent 2020 American College of Cardiology (ACC)/American Heart Association (AHA) and 2021 European Society of Cardiology (ESC)/European Association for CardioThoracic Surgery (EACTS) guidelines on the management of patients with valvular heart disease (VHD). ACC/ AHA and ESC/EACTS guidelines are both the updated versions of previous 2017 documents. Both guidelines fundamentally agree on the extended indications of percutaneous valve interventions, the optimal use of imaging modalities other than 2D echocardiography, the importance of a multidisciplinary Heart Team as well as active patient participation in clinical decision making, more widespread use of NOACs and earlier intervention with lower left ventricular dilatation thresholds to decrease long-term mortality. The differences between the guidelines are mainly related to the classification of the severity of valve pathologies and frequency of follow-up, level of recommendations of valve intervention indications in special patient groups such as frail patients and the left ventricular diameter and ejection fraction thresholds for intervention. (c) 2022 Elsevier Inc. All rights reserved.Öğe Effectiveness and Safety of Same-Day Discharge After Left Atrial Appendage Closure Using Moderate Conscious Sedation: One-Year Follow-Up Outcomes(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Feasibility of Same-Day Discharge Approach After Transcatheter Mitral Valve Repair Procedures: One-Year Follow-Up Outcomes(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Open Radial Artery (ORAS) Study(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Review of intravascular lithotripsy for treating coronary, peripheral artery, and valve calcifications(Wiley, 2024) Gruslova, Aleksandra B.; Inanc, Ibrahim H.; Cilingiroglu, Mehmet; Katta, Nitesh; Milner, Thomas E.; Feldman, Marc D.Management of intracoronary calcium (ICC) continues to be a challenge for interventional cardiologists. There have been significant advances in calcium treatment devices. However, there still exists a knowledge gap regarding which devices to choose for the treatment of ICC. The purpose of this manuscript is to review the principles of intravascular lithotripsy (IVL) and clinical data. The technique of IVL will then be compared to alternative calcium treatment devices. Clinical data will be reviewed concerning the treatment of coronary, peripheral artery and valvular calcifications. Controversies to be discussed include how to incorporate IVL into your practice, what is the best approach for treating calcium subtypes, how to approach under-expanded stents, what is the ideal technique for performing IVL, how safe is IVL, whether imaging adds value when performing IVL, and how IVL fits into a treatment program for peripheral arteries and calcified valves.Öğe Superficial Femoral Artery Endovascular Therapy: 12-Month Primary Patency Rates of Contemporary Endovascular Devices from 25,051 Patients(H M P Communications, 2022) Marmagkiolis, Konstantinos; Kilic, Ismail Dogu; Inanc, Ibrahim Halil; Iliescu, Cezar; Ajmal, Muhammad; Cilingiroglu, MehmetBackground. Approximately 5.8 million people experience peripheral arterial disease (PAD) in the United States today. Superficial femoral artery (SFA) disease is the most common cause of symptomatic PAD. New-generation nitinol stents, drug-coated stents, drug-coated balloons (DCB), covered stents, and directional or orbital atherectomy devices have shown promising results. However, clinical equipoise persists regarding the optimal selection of devices, largely attributable to the different inclusion criteria, study populations, length of lesions treated, definitions of patency and restenosis, and follow-up methods in the up-to-date pivotal trials. Methods. A prospective protocol was developed. We performed a literature search using PubMed from January 2011 to July 2021. All published articles including endovascular interventions in the SFA with reported 12-month primary patency rates as endpoints were included. Results. We identified 25,051 patients in 124 studies reporting 12-month primary patency rates in patients with SFA disease. Primary patency rates were (weighted average) 82.6% for drug-eluting stents, 77.2% for drug-coated balloons, 75.2% for covered stents, 73.9% for nitinol self-expanding stents, 66.1% for atherectomy, and 44.5% for bare balloon angioplasty. Conclusion. The most frequently used endovascular devices yielded various 12-month primary patency rates ranging from 44.5% to 82.6%. The increased variation in inclusion criteria, lesion length, and complexity of lesions between studies does not allow direct comparison between the individual devices. Larger randomized trials in specific patient populations comparing these modalities are needed well before we can make proper recommendations on the superiority of one device over the other.Öğe Transcatheter mitral valve repair in a liver transplant candidate(Wiley, 2022) Ates, Ismail; Mutlu, Deniz; Inanc, Ibrahim Halil; Marmagkiolis, Konstantinos; Iliescu, Cezar A.; Kilic, Ismail Dogu; Cilingiroglu, MehmetUntreated severe mitral regurgitation (MR) is associated with poor outcomes due to the adverse consequences of long-standing volume overload on the left ventricle and left atrium, which leads to pulmonary hypertension and right-sided heart failure. Early intervention results in favorable long-term outcomes making appropriate timing of intervention very critical. We present a 53-year-old male with severe symptomatic MR and right sided-heart failure which progressed to cardiac cirrhosis necessitating enrollment to the liver transplant list. Transcatheter mitral valve repair (TMVR) using MitraClip implantation resulted in impressive clinical improvement and resolution of cirrhosis. Eventually, the patient was taken off the transplant list. Treatment of severe MR may lead to improvements in congestive hepatopathy.Öğe Use of IVOCT for Assessment of the Lesion Characteristics as Well as Evaluation of Vascular Healing Effects of Different Technologies in PAD Patients(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Use of SAFARI 2n° as workhorse wire for left-sided structural heart interventions(Elsevier Inc, 2024) Inanc, Ibrahim H.; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Cilingiroglu, MehmetBackground: With the advances in percutaneous treatment technologies, the left atrial appendage occlusion (LAAO) and the transcatheter mitral valve repair using MitraClip (TMVR) are increasingly being performed today. The SAFARI 2n degrees guidewire is primarily used during transcatheter aortic valve implantation (TAVI), our group has also been using it during MitraClip and LAAO procedures. Our clinical study aimed to share our data on the safety and effectiveness for the use of the SAFARI 2n degrees guidewire during MitraClip or LAAO procedures. Methods: This study included a total of 1730 patients (948 patients of MitraClip and 782 of LAAO). It was designed as single arm, retrospective, and multicenter between July 2016 and August 2022. SAFARI 2n degrees guidewire was used exclusively during all the procedures. Results: A total of 1730 patients (male 55.8 %) were included in the study. There was no guidewire-related complications, stroke/transient ischemic attack, bleeding (minor/major/life-threatening), need for cardiac surgery, pneumonia, and vascular dissection/rupture in patients undergoing LAAO. There were 2 device-related pericardial effusions without tamponade. No stroke/transient ischemic attack, bleeding (minor/major/life-threatening), mortality, need for cardiac surgery, pneumonia, guidewire-related complication, pericardial effusion, vascular dissection/rupture, or clip embolization was observed in patients undergoing MitraClip. Conclusions: By taking advantage of its pre-shaped structure, the SAFARI 2n degrees guidewire seems to offer a reliable and safe device delivery for both MitraClip and LAAO procedures as a regular work horse wire. Our results should be confirmed by larger randomized or prospective trials.