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Öğe An investigation of cardiac effects in patients presenting to the pandemic clinic with suspected COVID-19(2022) Karslı, Aysun; Özsan, Sinan Oğuzhan; Comertpay, Ertan; Başkürkçü, Ahmet Faruk; Eroğlu, Oğuz; Deniz, TurgutAim: COVID-19 is a virus capable of causing cardiovascular complications. This study investigates whether any cardiac effect is present in patients presenting with suspected COVID-19 in the light of Electrocardiography (ECG) findings. Material and Method: This prospective study involved patients with chest pain presenting to the pandemic clinic with suspected COVID-19. Patients were divided into two groups based on their PCR results, PCR-positive and -negative. All participants’ demographic characteristics, presentation symptoms and the duration thereof, physical examination findings, laboratory results, and ECG findings were recorded. Patients with positive PCR results were invited for checks on the 15th day, when repeat ECG was performed. Results: A-50 patients with positive PCR results and 50 with negative PCR results were included in the study. The mean age of the entire patient group was 52.30±16.02 years, and 56% were women. No difference was determined between the positive and negative PCR result patients in terms of age or sex (p=0.116; 0.687, respectively). Presentation high sensitive cardiac Troponin (hs-cTn) levels were significantly higher in the patients with positive PCR results than in the PCR-negative patients (p<0.001). Rates of detection of ST-T change at presentation ECG were 38% in the patients with positive PCR results and 16% in those with negative PCR results (p=0.023). ST-T alteration persisted at 15th day ECG in 36% of the patients with positive PCR results. P-wave amplitude and mean heart rate were significantly higher at presentation ECG in the patients with positive PCR results than at ECG on day fifteen (p=0.038; <0.001 respectively). Conclusion: A cardiac effect does occur in patients with COVID-19, and this can be shown by means of ECG findings. The increase in P-wave amplitude at presentation ECG in patients with positive PCR results may represent a marker of COVID-19-related cardiac overload. ECG should be performed both at presentation and in the following days on COVID-19 patients presenting with chest pain, and care should be taken against potential ischemic ST-T alterations.Öğe The Diagnostic Value of sTWEAK in Acute Ischemic Stroke(GALENOS YAYINCILIK, 2020) Comertpay, Ertan; Vural, Sevilay; Eroglu, Oguz; Badem, Nermin Dindar; Bilgili, Yasemin Karadeniz; Coskun, FigenBackground: Considering the critical role of early diagnosis and management of acute ischemic stroke, biomarkers that can reliable assist in the diagnosis are still needed. These biomarkers should rapidly analyze, have high specificity for brain damage, and be available in the emergency settings for early diagnosis and exclusion of other conditions that mimic acute ischemic stroke. Soluble tumor necrosis factor-like weak inducer of apoptosis, a protein involved in the regulation of several biological functions, could be a potential acute ischemic stroke biomarker. Aims: To investigate the diagnostic value of soluble tumor necrosis factor-like weak inducer of apoptosis in patients with acute ischemic stroke and examine the relationship between ischemic area volume determined at diffusion-weighted magnetic resonance imaging and soluble tumor necrosis factor-like weak inducer of apoptosis. Study Design: A prospective, case-control study. Methods: This case-control prospective study included 36 patients with acute ischemic stroke and 36 healthy volunteers. Information on age, sex, presence of chronic disease, neurological examination findings, times of presentation to the emergency department after acute ischemic stroke, soluble tumor necrosis factor-like weak inducer of apoptosis levels, ischemic area volumes at diffusion-weighted magnetic resonance imaging, and 6-month mortality rates after stroke were recorded. The results were analyzed on SPSS 22.0 software (SPSS Inc., Chicago, IL, USA), and p<0.05 was considered statistically significant. Results: A soluble tumor necrosis factor-like weak inducer apoptosis cut-off value of 995.5 pg/mL exhibited a sensitivity of 80.5% and a positive predictive value of 82.5% with an area under the curve of 0.84 (95% confidence interval: 0.74-0.94; p<0.001). The mean soluble tumor necrosis factor-like weak inducer of apoptosis level - in the acute ischemic stroke group (1968.08=1441.99 mu g/L) were significantly higher than those in the control group (704.81 +/- 291.72 14,1) (p<0.001). No correlation was observed between soluble tumor necrosis factor-like weak inducer of apoptosis levels and ischemic area volume measured at diffusion-weighted magnetic resonance imaging (r=-0.008; p=0.07). The mean ischemic area volume was 505.68 +/- 381.10 and 60.96=80.89 mm(3) in the nonsurviving and surviving patients, respectively (p =.002). Conclusion: Soluble tumor necrosis factor-like weak inducer of apoptosis can be used in the diagnosis of acute ischemic stroke. However, it is inconclusive in estimating ischemic area volume and early mortality following acute ischemic stroke. Ischemic area volume measured at diffusion-weighted magnetic resonance imaging is a marker of poor prognosis and can be used in predicting early mortality.Öğe Dose-response effects of 8-week resistance training on body composition and muscular performance in untrained young women: A quasi-experimental design(Lippincott Williams & Wilkins, 2024) Ugurlu, Dondu; Gulu, Mehmet; Yapici, Hakan; Yagin, Fatma Hilal; Comertpay, Ertan; Eroglu, Oguz; Afonso, JoseBackground:The purpose of this study was to investigate the effects of 8-week resistance training with different training volumes on body composition, maximum strength, peak power, and muscle thickness in non-training women.Methods:This was a 3-arm, prospectively designed, randomized controlled trial. A total of 45 adult women aged 20.7 +/- 1 years, the mean heights of the participants were 166 +/- 0.07 cm, body weight was measured as 54.5 +/- 8.8 kg, and body mass index was 19.9 +/- 2.1 kg/m2. They were randomized to low-volume training resistance training (LVT; n = 15, 3 sessions of 12 exercises per week), moderate-volume training resistance training (MVT; n = 15; 4 sessions of 12 exercises per week), and high-volume resistance training (HVT; n = 15; 5 sessions of 12 exercises per week) for 8 weeks. The muscle thickness (MT) of the vastus lateralis was assessed at baseline and 8 weeks later using a portable ultrasound device.Results:A total of 39 adult women completed the study, with 2 participants from each group lost to follow-up. All experimental groups 1RM increased (P = .001, effect size (ES) = 0.463) All groups showed improved muscle thickness (MT) (P = .001) and CMJ (P = .004). The group x time interaction is statistically significant (P = .001) suggests that the changes in muscle thickness over time differ significantly between the different training volume groups (eta p(2)) is 0.368.Conclusion:In untrained young women, resistance training improved muscle hypertrophy, maximal strength, power, and body composition in untrained young women. However, 4 sessions MVT per week were superior to LVT and HVT sessions, suggesting a nonlinear dose-response relationship favoring moderate volume over low or high volumes, at least in previously untrained young women.Trial Registration:ClinicalTrials.gov (NCT06449300)Öğe Electrocardiography abnormality in a suicide attempt with levetiracetam(Asean Neurological Assoc, 2021) Comertpay, Ertan; Say, Bahar; Eroglu, Oguz; Deniz, Turgut; Coskun, FigenWe present a case of suicide attempt with levetiracetam (LEV) in an epilepsy patient. Multifocal ventricular contractions were observed together with bradycardia in this patient due to LEV overdose. Reported patient of LEV overdose in the literature rarely show electrocardiography findings. Although LEV is less toxic than other antiseizure medications, clinicians should be aware of its potential cardiac side effects.
