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Öğe Apelin 13: A promising biomarker for multiple sclerosis.(Sage Publications Ltd, 2016) Alpua, M.; Turkel, Y.; Dag, E.; Kisa, U.…Öğe Is there a relationship between Parkinsons disease and Chlamydia pneumoniae(Medknow Publications & Media Pvt Ltd, 2015) Turkel, Y.; Dag, E.; Gunes, H. N.; Apan, T.; Yoldas, T. K.Objectives: The aim was to investigate a possible relationship between Chlamydia pneumoniae and Parkinsons disease (PD). Study Design: Serum samples obtained from a cohort of 51 patients with PD and from 37 age- and sex-matched controls were assessed for the presence of antibodies. The control group was selected from healthy people. In both groups, 5 mL of blood was taken and after centrifugation frozen at -80 degrees C. Presence and concentration for C. pneumoniae IgM and IgG were determined by the enzyme linked immunosorbent assay (ELISA) and immunofluorescence (IFA), using C. pneumoniae IgG and IgM kit (Euroimmun, Germany). Results: Chlamydia pneumoniae IgG was positive in 50 (98%) patients in ELISA study. C. pneumoniae IgG was positive in 34 (92%) control subjects in ELISA study. C. pneumoniae IgG positivity in patients was slightly higher, but the difference did not reach statistical significance (P = 0.17). No statistically significant difference was found between the patient and the control groups in IFA study (P >= 0.5). C. pneumoniae IgM results (both ELISA and IFA study) was negative in the both PD group and control group.Öğe Mini mental state exam versus Montreal cognitive assessment in patients with age-related macular degeneration(Verduci Publisher, 2014) Dag, E.; Otrnek, N.; Ornek, K.; Gunay, F.; Turkel, Y.OBJECTIVE: To compare the ability of the MMSE and MoCA to identify cognitive dysfunction in patients with age-related macular degeneration (AMD). PATIENTS AND METHODS: The study included 81 (29 female, 52 male) AMD patients who were recruited from the Ophthalmology Department of Kirikkale University during 2012. Participants were screened for cognitive impairment using the MMSE and MoCA. The scores were recorded for all participants. The primary outcome measure was the proportion of patients with a score less than 21 on either test. RESULTS: The percentage of subjects who scored below a cut off of 21/30 was higher on the MoCA (48.1%) than on the MMSE (18.5%) (p = 0.05). The range and standard deviation of scores was larger with the MoCA (7-30, 5.34) than with the MMSE (19-30, 3.26). There was a more pronounced ceiling effect of the MMSE than of the MoCA. The mean MMSE scores of dry-and wet-type AMD patients was significantly higher than the MoCA scores of the same patients (p = 0.000 and p = 0.000). CONCLUSIONS: The MoCA seems to be more sensitive than the MMSE to early cognitive impairment in AMD patients.Öğe Smell functions in patients with multiple sclerosis: a prospective case-control study(Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2016) Kandemir, S.; Muluk, N. B.; Melikoglu, B.; Dag, E.; Inal, M.; Sahin, O.Objectives: The aim of this study is to evaluate the smell function in patients with multiple sclerosis (MS). Methods: Twenty subjects (six males, 14 females) who were diagnosed as having MS, based on the 2010 Revised McDonald criteria, and 20 healthy individuals (six males, 14 females) were included in this study. In order to measure smell identification abilities, each subject completed the 12-item Brief Smell Identification Test (BSIT). Central and peripheral regions of smell were measured using cranial magnetic resonance (MR) images. The central regions of smell (the temporal lobe insular gyrus and the corpus amygdala) and the peripheral regions of smell (the olfactory bulb, tract and sulcus) were examined in the cranial MR images. Regions of smell were also evaluated for the presence of MS lesions (plaques). Results: The total BSIT scores of the subjects in the MS group were found to be significantly lower than those of the control group (p< 0.05). In the MS group, measurement values of the central regions of smell (right corpus amygdala diameter, right and left corpus amygdala) were significantly higher than those of the control group (p< 0.05). There were no MS lesions in the peripheral regions of smell, but MS lesions were observed in the central regions: the right temporal lobe insular gyrus (four patients, 20.0%); the left temporal lobe insular gyrus (two patients, 10.0%); and the right corpus amygdala (one patient, 5.0%). While these results are not sufficient for statistical analysis, the total smell scores of these patients were found to be low. Conclusion: There is a deterioration in the smell functions of patients with MS. Therefore, we highly recommend that ENT specialists use the easily accessible and reliable BSIT for the diagnosis of smell disorders.
