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    Evaluation of Tp-e/QTc Ratio in Obesity
    (Galenos Publ House, 2024) Uyan, Umut; Aydın, Cihan; Demirkiran, Aykut; Karadeniz, Muhammed; Alpsoy, Seref
    Aim: We aimed to detect simple findings that might predict sudden cardiac death in electrocardiography recordings in obese patients. Materials and Methods: Patients were included in our study retrospectively. Two groups with body mass index (BMI) >= 30 kg/m(2) (Group 1) and BMI <30 kg/m(2) (Group 2) were sampled from the study population with similar baseline characteristics, biochemical and echocardiographic features. Ventricular repolarization parameters were compared between the two groups. The Tp-e interval was defined as the period of time between the T waves' peak and their end. Tp-e/QTc ratio was calculated. Results: This study included 190 participants. There were no differences between the two groups in terms of age (p=0.42), diabetes (p=0.238), hypertension (p=0.877), smoking (p=1.000), medical treatment used, laboratory parameters, left ventricular ejection fraction (p=0.673), and left ventricular mass index (p=0.089). The QTc interval was similar between the groups (416.4 +/- 11.6 ms, and 422.1 +/- 14.8 ms; p=0.081). Tp-e, and Tp-e/QTc ratio were greater in Group 1 (93.1 +/- 6.2 ms, and 67.7 +/- 2.5 ms; p=0.00; 0.22 +/- 0.02, and 0.15 +/- 0.01; p=0.001). Twelve months after the first examinations, six deaths were noted in the obese group (p=0.001). Conclusion: Our study results showed that the Tp-e interval and Tp-e/QTc ratio were significantly increased, and sudden cardiac death was more common in patients with BMI >= 30 kg/m(2).
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    Predictors of Severity of Coronary Artery Disease in Patients with Acute ST-elevation Myocardial Infarction
    (Galenos Publ House, 2024) Karadeniz, Muhammed; Aydın, Cihan; Demirkiran, Aykut; Alp, Çağlar
    Aim: Our study aims to investigate the relationship between platelet-lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), and the correlation between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) scores. Materials and Methods: The patients were divided into three groups according to their SYNTAX score. Group 1 included patients with a SYNTAX score <23, group 2 with a SYNTAX score of 23-32, and group 3 with a SYNTAX score of >33. PLR was calculated as the ratio of platelet count to lymphocyte count. Results: In multivariate logistic regression analysis, high PLR and NLR ratios and older age were independent predictors of high SYNTAX score II [odds ratio (OR): 1.052; 95% confidence interval (CI): (0.998-1.119), p=0.011; OR: 1.093; 95% CI: (1.016-1.175), p=0.016; OR:1.023; 95% CI: (1.0101.038), p=0.001, respectively. Patients with high PLR had significantly higher SYNTAX scores [121.7 (114.2-129.3) in group 1; 139.4 (125.9-153.0) in group 2, 187.0 (141.8-232.2) in group 3; p<0.001], and there was a positive correlation between PLR, NLR and SYNTAX scores (r=0.52, p<0.001; r=0.58, p<0.001, respectively). Conclusion: PLR and NLR were associated with the severity and complexity of coronary artery disease in patients with acute ST-elevation myocardial infarction.
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    Role of simple inflammatory parameters in predicting the severity of coronary artery disease
    (Assoc Medica Brasileira, 2023) Aydin, Cihan; Uyan, Umut; Karadeniz, Muhammed; Demirkiran, Aykut
    OBJECTIVE: In our study, we aimed to find simple, useful biomarkers in patients with non-ST elevation myocardial infarction to predict coronary artery severity.METHODS: Between May 2022 and December 2022, patients diagnosed with non-ST elevation myocardial infarction according to the European cardiology guidelines were included in our study. The Synergy between PCI with Taxus and Cardiac Surgery score was calculated to determine the severity of coronary artery disease. These patients were classified into two groups according to Synergy between PCI with Taxus and Cardiac Surgery >= 23 and Synergy between PCI with Taxus and Cardiac Surgery<23 scores. Biochemical markers such as platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were studied in blood tests taken before coronary angiography in patients diagnosed with non-ST elevation myocardial infarction according to current guidelines. These two groups were compared in terms of the data obtained.RESULTS: There were 281 patients in group 1 and 67 patients in group 2. There was no significant difference between the two groups in terms of demographic data such as age and gender. Platelet-to-lymphocyte ratio [group 1=125 (26-134) and group 2=156 (73-293); p=0.001] and neutrophil-to-lymphocyte ratio [group 1=2.71 (1.3-30.2) and group 2=3.2 (2.1-32.1); p=0.002] were higher in the group of patients with a Synergy between PCI with Taxus and Cardiac Surgery score of <23, while lymphocyte-to-monocyte ratio [group 1=3.6 (0.56-11) and group 2=3.4 (0.64-5.75); p=0.017] was lower in group 2.CONCLUSION: We observed that elevated platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios showed coronary artery severity. Multivessel disease and chronic total occlusion rates were observed to be higher in patients with high platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios.