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    İDİYOPATİK PARKİNSON HASTALARINDA OLFAKTÖR BULBUS VOLÜM VE OLFAKTÖR SULKUS DERİNLİĞİNİN MANYETİK REZONANS GÖRÜNTÜLEME İLE DEĞERLENDİRİLMESİ
    (2019) Doğan, Adil; Burulday, Veysel; Alpua, Murat
    Amaç: Bu çalışmada idiopatik Parkinson hastalığı (İPH) olanbireylerde, olfaktör bulbus (OB) hacimleri ve olfaktör sulkus(OS) derinliğini incelemek amaçlandı.Gereç ve Yöntem: Bu çalışma retrospektif bir olgu kontrolçalışması olarak dizayn edildi. Manyetik rezonans görüntüleme(MRG) incelemeleri, standart bir kafa koili kullanılarak, 1.5-tesla MRG sistemi (Philips MRI Systems, Achieva Release 3.2Level 2013-10-21, Philips Medical) ile yapıldı. OB hacimhesaplamaları ve OS derinlik ölçümü için yağ baskılı T2Akoronal kesitler kullanıldı ve İPH grubundaki hastalarınverileri sağlıklı kontrol grubu ile karşılaştırıldı.Bulgular: Çalışmaya yaş ortalaması 69.07±10.48 yıl olan 39İPH hastası ile yaş ortalaması 69.57±10.12 yıl olan 40 sağlıklıkontrol dahil edildi. İPH hasta grubu ile kontrol grubukarşılaştırıldığında sağ (30.12±6.49, 39.13±6.55) ve sol(32.57±8.08, 38.17±4.96) OB hacimleri ile sağ (6.91±0.9,7.39±0.65) ve sol (6.82±0.7, 7.38±0.58) OS derinliklerininhasta grupta kontrollere göre belirgin olarak azaldığı görüldü.Sonuç: İPH hastalarında, OB hacimleri ve OS derinliklerininsağlıklı kontroller göre belirgin olarak azaldığı ve bu durumunhastaların tedavi ve yaşam kalitelerinin yönetimi açısındanönem taşıdığı sonucu ortaya çıkmıştır.
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    Kronik Dönemde İnme Geçirmiş Hastaların Olfaktör Bulbus Hacimlerinin Ve Olfaktör Sulkus Derinliklerinin Değerlendirilmesi
    (2019) Doğan, Adil; Burulday, Veysel; Alpua, Murat
    AMAÇ: Bu çalışmada, kronik dönemdeki inme geçirmiş hastaların olfaktör bulbus (OB) hacimleri ve olfaktör sulcus (OS) derinliğini değerlendirmek amaçlandı. GEREÇ VE YÖNTEM: Bu çalışma retrospektif ve olgu kontrol çalışması olarak planlandı. Kronik dönemde (>6 ay) inme geçirmiş hastaların OB hacimleri ve OS derinliği ölçümü, manyetik rezonans görüntüleme 1.5-tesla MRG sistemi (Philips MRI Systems, Achieva Release 3.2 Level 2013-10-21, Philips Medical) ile standart kafa coili kullanılarak yapıldı. OB hacim ve OS derinliği ölçümleri, yağ baskılı T2 koronal kesitler kullanılarak yapıldı. İnmeli hastaların verileri sağlıklı kontrol grubu ile karşılaştırıldı. BULGULAR: Çalışmaya, yaş ortalaması 47.7±10.7 yıl olan 45 (21 erkek, 24 kadın) inme geçirmiş hasta ile yaş ortalaması 44.5±8.7 yıl olan 45 (19 erkek-26 kadın) sağlıklı kontrol dahil edildi. İnme grubu ile kontrol grubu karşılaştırıldığında sağ (34.8±10.1 vs. 44.0±7.4 mm3) ve sol OB (34.9±10.0 vs. 49.1±6.2 mm3) hacimlerinin ortalama değerlerinin inme geçirmiş grupta kontrollere göre belirgin olarak azaldığı görüldü. Olfaktör sulkus derinliği ise sağda gruplar arasında değişiklik göstermezken (7.0±0.0 vs. 7.0±0.7 mm) ve solda inmeli grupta daha yüksek bulundu (7.1±0.9 vs. 6.7±0.6 mm). SONUÇ: İnme sonrası kronik dönemdeki hastalarda olfaktör bulbus hacimlerinin azaldığı görüldü.
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    MR spectroscopy features of normal appearing white matter in patients with lung cancer
    (Scientific Publishers of India, 2017) Doğan, Adil; Sigirci, Ahmet; Ermiş, Hilal; Aytemur, Zeynep Ayfer; Baysal, Tamer; Alkan, Alpay; Yoloğlu, Saim
    Context: Spectroscopic imaging can be helpful to identify metabolite changes in a normal appearing brain parenchyma after MR imaging in patients with lung cancer. Aims: To detect metabolic changes in the cerebellar and cerebral normal appearing white matter with single-voxel H-MR spectroscopy (MRS) in patients with lung cancer. Methods and material: MRS was performed in the Cerebellar White Matter (CWM) and Parietal White Matter (PWM) of patients with lung cancer (n=38; age range: 44-82 y; mean age: 66.1 ± 8.7) and an age-matched control group (n=32; age range: 42-80 y; mean age: 62.9 ± 8). Biopsies of lung masses showed 25 Non-Small Cell Lung Cancer (NSCLC) and 13 Small Cell Lung Cancer (SCLC). NAA/Cr, NAA/Cho and Cho/Cr ratios were calculated. Statistical analysis used: The unpaired-t test was used for the assessment of metabolite ratio differences between patients and control subjects. Mann-Whitney U test was used among SCLC, NSCLC, and control group for the evaluation of metabolite ratio differences. Results: The Cho/Cr ratios in the CWM were significantly lower in the patients compared to controls (p=0.03). The Cho/Cr ratio of patients with SCLC was significantly lower in PWM than both NSCLC (p=0.02) and control group (p=0.03). Conclusion: Decreased Cho/Cr ratio possibly represents increased uptake of Cho or reduced brain function. These results may be important in assessing patients with lung cancer in order to help with treatment planning and prognosis. © 2017, Scientific Publishers of India, All rights reserved.
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    Olfactory Fossa and New Angle Measurements: Lateral Lamella-Cribriform Plate Angle
    (Lippincott Williams & Wilkins, 2019) Asal, Neşe; Muluk, Nuray Bayar; İnal, Mikail; Şahan, Mehmet Hamdi; Doğan, Adil; Arıkan, Osman Kürşat
    Objectives: The authors investigated the olfactory fossa (OF) in patients with unilateral nasal septal deviation (NSD) and presented the lateral lamella-cribriform plate angle (LLCPA). Methods: Paranasal sinus computed tomography images of 300 adult subjects with unilateral NSD (111 males, 189 females) were evaluated retrospectively. Septal deviation angle (SDA), Keros Classification, OF depth and width, LLCPA; and orbital plate and cribriform plate (OPCP) distance were measured. Results: The OF depth values (ipsilateral, contralateral) were found as Keros III >Keros II >Keros I (P-adjusted<0.0175). The OF width values (ipsilateral) were detected as Keros I >Keros II and Keros I >Keros III (P-adjusted<0.0175). In patients with higher SDA values, ipsilateral OF depth values decreased (P<0.05). The LLCPA and OPCP values were higher in Keros I and lower in Keros III (P<0.05). Conclusion: In patients with lower LLCPA and OPCP, endoscopic sinus surgery will be more dangerous for trauma to lateral lamella and intracranial penetration.
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    Pancreas and kidney changes in type 2 diabetes patients: the role of diffusion-weighted imaging
    (Tubitak Scientific & Technological Research Council Turkey, 2021) Şahan, Mehmet Hamdi; Özdemir, Adnan; Asal, Nese; Karadeniz Bilgili, Yasemin Mirace; Doğan, Adil; Güngüneş, Aşkın
    Background/aim: The aim of this study was to compare renal and pancreatic apparent diffusion-coefficient (ADC) values of diabetic patients and control subjects and to examine their potential association with several diabetes-related clinical parameters. Materials and methods: A total of 80 sex-and age-matched patients were included in the study. Of them, 40 were patients with type 2 diabetes and 40 were nondiabetic participants. Abdominal diffusion-weighted MRIs of both groups were retrospectively reviewed. Diabetes-related clinical parameters were recorded. Results: The difference between the mean ADC values of the patient group and the control group was significant (p = 0.012). It was also found that the mean pancreatic ADC values of diabetic patients and the control group significantly differed (p = 0.02). Besides, there were positive correlations between the mean pancreatic ADC values and age, Hb1Ac level, treatment type, and disease duration (p < 0.05). While eGFR values positively correlated with the mean renal ADC values (p < 0.05), there were negative correlations between such values and age, serum creatinine level, and disease duration (p < 0.05). Conclusion: Renal and pancreatic ADC values of diabetic patients could potentially play a role, as markers of renal and pancreatic functions, in clinical decisions in the follow-up of such patients.
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    Pancreas and kidney changes in type 2 diabetes patients: The role of diffusion-weighteimaging
    (Turkiye Klinikleri, 2021) Şahan, Mehmet Hamdi; Özdemir, Adnan; Asal, Neşe; Karadeniz Bilgili, Yasemin Mirace; Doğan, Adil; Güngüneş, Aşkın
    Background/aim: The aim of this study was to compare renal and pancreatic apparent diffusion-coefficient (ADC) values of dipatients and control subjects and to examine their potential association with several diabetes-related clinical parameters. Materials and methods: A total of 80 sex-and age-matched patients were included in the study. Of them, 40 were patients with type 2 diabetes and 40 were nondiabetic participants. Abdominal diffusion-weighted MRIs of both groups were retrospectively reviewed. Diabetes-related clinical parameters were recorded. Results: The difference between the mean ADC values of the patient group and the control group was significant (p = 0.012). It was also found that the mean pancreatic ADC values of diabetic patients and the control group significantly differed (p = 0.02). Besides, there were positive correlations between the mean pancreatic ADC values and age, Hb1Ac level, treatment type, and disease duration (p < 0.05). While eGFR values positively correlated with the mean renal ADC values (p < 0.05), there were negative correlations between such values and age, serum creatinine level, and disease duration (p < 0.05). Conclusion: Renal and pancreatic ADC values of diabetic patients could potentially play a role, as markers of renal and pancreatic functions, in clinical decisions in the follow-up of such patients. © TÜBİTAK.
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    Peripheral and Central Smell Regions in Migraine Patients using Maras Powder (Smokeless Tobacco): A Magnetic Resonance Imaging Evaluation
    (Thieme Medical Publ Inc, 2022) Doğan, Adil; Bayar Muluk, Nuray; İnanç, Yılmaz
    Objective In the present study, we investigated the efficacy of Mara powder (smokeless tobacco) use on smell regions in migraine patients. Methods The cranial magnetic resonance imaging images of 58 adult patients were included in this retrospective study. Thirty-eight of them were migraine patients (18 of them using Mara powder and 20 of them not using Mara powder) and 20 of them were healthy controls. Bilateral peripheral (olfactory bulb [OB] volume and olfactory sulcus depth) and central smell regions (insular gyrus area and corpus amygdala area) as well as nasal septal deviation were evaluated. Results In migraine patients (using or not using Mara powder), OB volumes, and in Mara powder using migraine patients, corpus amygdala areas were lower than those in the control group (p<0.05). In Mara powder-using migraine patients, left insular gyrus areas of the females were significantly lower than the males (p<0.05). Conclusion We concluded that the peripheral smell region of the OB volume decreased in migraine patients (using or not using Mara powder). However, the central smell region of corpus amygdala area decreased in Mara powder using migraine patients. Mara powder usage may increase vascular shrinkage, and the decrease in OB volume and corpus amygdala area becomes prominent. It can be said that Mara powder usage may cause a size decrease in the peripheral and central smell regions in migraine patients. Therefore, migraine patients and non-migrainous people should be noticed for the harmful effects of Mara powder on the vascular system and smell system in the aspects of OB volume and corpus amygdala area decrease.