Yazar "Dogru M.T." seçeneğine göre listele

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    Coxiella burnetii seropositivity and coronary ectasia
    (Cardiology Academic Press, 2014) Dogru M.T.; Alpay Y.; Simsek V.; Unal N.; Askar S.; Ebinc H.; Yildirim N.
    Bacterial infections could contribute to atherosclerotic inflammation. We investigated the association of Coxiella Burnetii seropositivity with the atherosclerotic lesion types (obstructive and/or ectatic), serum lipid profile, nitric oxide (NO),total sulfhydryl (SH) groups and malonyldialdehyde (MDA) levels. A total of 150 participants (73 male, mean age: 56.6 ± 11.4 years; 77 female, mean age: 57.3 ± 13.0 years) were enrolled into the study. Coronary angiography was performed all the participants. We also performed serum lipid profile, NO, SH groups and MDA levels to determine the changes in chronic and acute Coxiella burnetii infections. The patients with obstructive and ectatic coronary artery lesions were of higher Coxiella phase I IgG titer (The marker of chronic Coxiella infection) than those of other coronary artery disease groups(One Way ANOVA, p=0.001). There were higher serum total cholesterol levels in the patients with chronic Coxiella infection than those of other patients. The chronic Coxiella Burnetii infection may be an important factor for the formation of coronary artery ectasia on basement of atherosclerotic coronary artery disease. Hyperlipidemia might also facilitate and augment this association.
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    The effects of ACE gene polymorphism on the serum antioxidant capacity
    (Cardiology Academic Press, 2014) Simsek V.; Dogru M.T.; Boyuaga H.; Sayin Kocakap D.B.; Yildirim N.; Guzel M.; Alp C.
    The association between angiotensin converting enzyme (ACE) gene polymorphism serum total sulfhydryl groups (Total SH), nitric oxide (NO) and malonyldialdehyde (MDA) levels and coronary artery disease (CAD) was already shown by the studies. In this study, we aimed to investigate the effects of ACE polymorphism on the serum total SH groups, NO and MDA levels in patients with and without CAD. A total of 146 participants (71 male, mean age: 56.0 ± 11.9 years; 75 female, mean age: 57.1 ± 13.5 years) were enrolled into the study. All the patients were performed coronary angiography. The associations between ACE genotypes (DD,ID,II) and coronary artery disease were evaluated by statistically methods. We determined that there was statistically significant differences about the serum levels of NO, total SH and MDA among ACE genotypes in the patients without CAD (One Way ANOVA, P=0.005, P=0.004 and p<0.001, respectively). Only total SH levels was of statistically significant difference among ACE genotypes in the patients with CAD(One Way ANOVA, P=0.034) In conclusion we determined that there were significant differences about serum total antioxidant capacity, MDA and NO levels among ACE (I/D) genotypes.
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    Serum orexin-a level and the severity of coronary artery disease: Original article
    (Cardiology Academic Press, 2014) Simsek V.; Dogru M.T.; Boyunaga H.; Caglayan O.; Yildirim N.; Tulmaç M.; Ebinc H.
    In this study, we aimed to investigate the correlations of serum Orexin-A level (SOAL) and the severity of coronary artery disease (CAD). A total of 80 participants (mean age: 55.7±12.7 years) were enrolled into the study. SOAL, electrocardiography and transthoracic echocardiography and 24 Hour Holter monitoring (24HHM) and coronary angiography were performed in all participants. Autonomic functions were assessed using the data of Heart Rate Variability measurements. Patients were categorized into three groups according to their Gensini scores as: Group 1: The patients with normal coronary angiogram, Group 2: The patients with mild CAD (Gensini <20) and Group 3: The patients with severe CAD (Gensini ?20). A total of 28 patients were Group 1 (mean age 51.8±12.0 years), 25 patients were Group 2 (mean age 57.7±11.6 years) and 27 patients were Group 3 (mean age 57.6±13.6 years). There were statistically significant differences in SOAL (p=0.004) among the groups. We found that SOAL had statistically significant associations with Gensini score and LF/HF (Sympathetic activity) values. (F= 15.299; p=0.004 and F= 15.470; p=0.004, respectively). Serum Orexin-A levels are positively correlated with severity of CAD and sympathetic activity.