Yazar "Durmaz, Senay" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim
    Öğe
    Author's reply: 'Many confounding factors can affect mean platelet volume in euthyroid Hashimoto's thyroiditis patients'
    (Lippincott Williams & Wilkins, 2017) Carlioglu, Ayse; Timur, Ozge; Durmaz, Senay; Ayhan, Mehmet E.
    …
  • Küçük Resim
    Öğe
    Evaluation of Serum Lipid Parameters in Acromegaly Patients
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2019) Keskin, Havva; Cadirci, Kenan; Kaya, Yasemin; Durmaz, Senay; Arslan, Abdulmuttalip; Yildiz, Faruk; Carlioglu, Ayse
    Objective: In acromegaly, the incidence of cardiovascular disease is higher compared to healthy population because of the association of secondary cardiovascular disease risk factors such as hypertension, glucose intolerance, dyslipidemia, and insulin resistance. This study aimed to evaluate the relationship between Growth Hormone (GH), Insulin-like Growth Factor-1 (IGF-1), and lipid profiles in patients with newly diagnosed acromegaly. Methods: This study included 57 newly diagnosed acromegaly patients and 31 healthy control cases. Blood samples were taken after a 12-hour night fasting to analyze the levels of the hormones, the lipid profiles, and the fasting blood glucose. Results: The mean of LDL-C level in the acromegaly group and control group were respectively 140.2 +/- 61.3 mg/dL and 115.6 +/- 30.4 mg/dL, (p=0.029), triglyceride level 137.6 +/- 84.0 mg/dL and 102.9 +/- 43.0 mg/dL, (p=0.027) and HDL-C level 41.5 +/- 10.5 mg/dL and 50.5 +/- 10.6 mg/dL, (p=0.001). There was a significant positive correlation between GH levels of LDL (r=0.375, p=0.002), TG (r=0.302, p=0.01), IGF-1 (r=0.634, p=0.0001) and HOMA-IR (r=0.699, p=0.0001), IGF-1 and LDL levels (r=0.295, p=0.01) and TG (r=0.476, p=0.0001). There was a negative correlation between HDL and GH (r=-0.399, p=0.001) and HDL with IGF-1 (r=-0.310, p=0.01). Conclusions: Acromegaly is a disorder characterized by an excess of GH and GH appears to adversely affect the lipid profile. It can be considered that this risk factor may be eliminated by the control of the levels of GH and IGF-1 in acromegaly patients. Further studies seem necessary for more clarifica-tion.
  • Küçük Resim
    Öğe
    Nonfunctional adrenal incidentalomas may be related to bisphenol-A
    (SPRINGER, 2020) Eker, Fatih; Gungunes, Askin; Durmaz, Senay; Kisa, Ucler; Celik, Zeynep Rumeysa
    Purpose Bisphenol-A (BPA) is an endocrine-disrupting chemical that may affect the hormones and their receptors. The aim of this study is to determine whether BPA has an effect on the development of nonfunctional adrenal incidentaloma (NFAI). Methods Fifty patients who were admitted to endocrinology outpatient clinics and diagnosed as NFAI were included in the study. Fifty healthy people without adrenal mass and adrenal pathology in the upper abdominal computerized tomography or magnetic resonance imaging were also included as control group. Age, gender and body mass index of the study groups were similar. The serum samples for BPA were stored at -80 degrees C in refrigerator until working in the lab. Serum BPA levels were measured using ELISA technique. Results Mean serum BPA level was 7.06 +/- 3.96 ng/ml in NFAI patients and 4.79 +/- 3.01 ng/ml in control group. Serum BPA level was significantly higher in NFAI group than control group (p = 0.001). Serum BPA levels were also found to be significantly higher in women with NFAI than in men with NFAI (p = 0.019). Conclusions The mechanisms of NFAI development have not been clarified yet. Increased BPA exposure with developed industrialization may play a role in NFAI formation. For the reduction of BPA exposure, the use of plastic prepacked products, plastic containers, and safety measures are essential for public health.