Yazar "Dursun, Ali" seçeneğine göre listele

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    Öğe
    Artificial Neural Networks with Turkey Interconnected System for Day Ahead Market Transmission Lines Estimated Losses
    (Kırıkkale Üniversitesi, 2020) Dursun, Ali; Eke, İbrahim; Tezcan, Süleyman Sungur
    Today, the cost of energy losses is very important because of the negativeeffects on the national economies. Transmission system losses are not desirablebut cannot be reset. In this context, our country’s interconnected transmissionsystem that occurred energy losses, balancing on March 28, 2015 and SettlementRegulation (BSR). What added in accordance with the provisions of the TemporaryArticle 27, Turkey Electricity Transmission Company (TEIAS) is left to theliability. Since the mentioned date, TEİAŞ has made its predictions as a marketparticipant in the day ahead market operated by Energy Markets OperationCompany (EPİAŞ) and has been obliged to purchase these amounts from the marketbefore the actual data appear. The average resource allocated by TEAIS for thetransmission system losses from the income ceiling is 1 500 000 000 TL.  It allocates a significant portion of thisresource to forecast errors for the day ahead market. In this study, it isaimed to reduce the amount paid by making transmission system loss estimates inthe most accurate way and to contribute to the national economy especially inTEİAŞ. In this context, priority has been described as the interconnectedtransmission system losses and Turkey electricity market, are given informationabout artificial neural networks.  Finally,in order to provide the data required, originally made software, TurkeyInterconnected Transmission Forecast program is described and the estimatesmade by means of artificial neural networks were compared on an hourly basiswith the actual transmission losses. If TEIAS uses this study in transmissionsystem loss estimations, it is foreseen to reduce the amount and the amount ofenergy imbalance.
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    Öğe
    Gün Öncesi Piyasası için Yapay Sinir Ağları ile Türkiye Enterkonnekte Sistemi İletim Hatları Kayıplarının Tahmini
    (2020) Dursun, Ali; Eke, İbrahim; Tezcan, Süleyman Sungur
    Günümüzde ülke ekonomilerine olumsuz etkileri nedeniyle enerji kayıplarının maliyeti oldukça önem arz etmektedir. İletim sistemi kayıpları istenilen bir durum olmamakla beraber sıfırlanması da mümkün değildir. Bu kapsamda, ülkemiz enterkonnekte iletim sisteminde meydana gelen enerji kayıpları, 28 Mart 2015 tarihinde Dengeleme ve Uzlaştırma Yönetmeliği(DUY)’ne eklenen geçici 27. madde hükümleri doğrultusunda, Türkiye Elektrik İletim Anonim Şirketi(TEİAŞ) yükümlülüğüne bırakılmıştır. Söz konusu tarihten itibaren Enerji Piyasaları İşletme Anonim Şirketi(EPİAŞ) tarafından işletilen gün öncesi piyasasında TEİAŞ piyasa katılımcısı olarak ön görülerini yapıp, gerçekleşen veriler ortaya çıkmadan önce bu miktarları piyasadan satın almakla yükümlü hale getirilmiştir. TEAİŞ’ın iletim sistemi kayıpları için gelir tavanından ayırdığı kaynak ortalama 1.500.000.000 TL, dir. Bu kaynağın, 150.000.000 TL’lik kısmını ise gün öncesi piyasası için yapılan tahmin hatalarına ayırmaktadır. Bu çalışmada, iletim sistemi kayıp tahminlerinin en doğru şekilde yapılarak ödenen tutarın azaltılması ve TEİAŞ özelinde ülke ekonomisine katkı sağlanması amaçlanmıştır. Bu kapsamda, öncelikli olarak enterkonnekte iletim sistemi kayıpları ve Türkiye elektrik piyasası anlatılmış, yapay sinir ağları hakkında bilgi verilmiştir. Son olarak, gerekli olan verilerin sağlaması amacıyla, özgün olarak yazılımı yapılan, Türkiye Enterkonnekte İletim Kaybı Tahmin programı olarak adlandırılan yazılım programı anlatılmış ve yapay sinir ağları aracılığıyla yapılan tahminler, gerçekleşen iletim kayıpları ile saatlik olarak kıyaslanmıştır. Çalışmanın, TEİAŞ tarafından iletim sistemi kayıp tahminlerinde kullanması durumunda, enerji dengesizlik miktarının ve tutarının azalması öngörülmektedir.
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    Öğe
    Investigation of Analgesic Minimum Effective Dose of Apelin-13 With Different Doses of Intraperitoneal Injections and its Effects on Kidney Tissue
    (WILEY, 2020) Dursun, Ali; Özdemir, Çagri; Sezen, Şaban; Küçük, Ayşegül; Arslan, Mustafa
    [Özet Yok]
  • Küçük Resim
    Öğe
    Microarray based mutational analysis of patients with methylmalonic acidemia: Identification of 10 novel mutations
    (Academic Press Inc Elsevier Science, 2012) Dündar, Halil; Özgül, Rıza Köksal; Güzel-Ozantürk, Ayşegül; Dursun, Ali; Sivri, Serap; Aliefendioğlu, Didem; Tokatli, Ayşegül
    Methylmalonic acidemia is an autosomal recessive metabolic disorder affecting the propionate oxidation pathway in the catabolism of several amino acids, odd-chain fatty acids, and cholesterol. Methylmalonic acidemia is characterized by elevated levels of methylmalonic acid in the blood and urine. Mutations in the MUT gene, encoding methylmalonyl-CoA mutase carries out isomerization of L-methylmalonyl-CoA to succinyl-CoA, cause methylmalonic acidemia. In this study, 30 Turkish patients diagnosed with mut methylmalonic acidemia were screened for mutations using custom designed sequencing microarrays. The study resulted in detection of 22 different mutations, 10 of which were novel: p.Q132*, p.A137G, c.753 + 1T, p.T387I, p.Q514E, p.P615L, p.D625V, c.1962_1963delTC, p.L674F, and c.2115_2116insA. The most common, p.P615T, was identified in 28.0% of patients. These results suggest that microarray based sequencing is a useful tool for the detection of mutations in MUT in patients with mut methylmalonic acidemia. (C) 2012 Elsevier Inc. All rights reserved.
  • Küçük Resim
    Öğe
    A newborn with VLCAD deficiency Clinical, biochemical, and histopathological findings
    (Springer, 2007) Aliefendioglu, Didem; Dursun, Ali; Coskun, Turgay; Akcoeren, Zuhal; Wanders, Ronald J. A.; Waterham, Hans R.
    Here we report a newborn with VLCAD deficiency with a severe neonatal onset type who presented with hypoglycemia, cardiomyopathy, mild hepatomegaly and slight hypoalbuminemia. The patient was also homozygous for a new missense mutation (R456H). Postmortem examination of the liver, heart and skeletal muscle revealed diffuse lipid accumulation in various amounts. Mild lobular and portal fibrosis as well as severe macrovesicular steatosis were also found in the liver. The fatal course of the patient may have resulted from diffuse lipid accumulation in the liver and myocardium, which probably began during the intrauterine life with slight hypoalbuminemia as a silent marker of this process.
  • Küçük Resim
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    Novel Mutations in the PC Gene in Patients with Type B Pyruvate Carboxylase Deficiency
    (Springer-Verlag Berlin, 2013) Ostergaard, Elsebet; Duno, Morten; Moller, Lisbeth Birk; Kalkanoglu-Sivri, H. Serap; Dursun, Ali; Aliefendioglu, Didem; Wibrand, Flemming
    We have investigated seven patients with the type B form of pyruvate carboxylase (PC) deficiency. Mutation analysis revealed eight mutations, all novel. In a patient with exon skipping on cDNA analysis, we identified a homozygous mutation located in a potential branch point sequence, the first possible branch point mutation in PC. Two patients were homozygous for missense mutations (with normal protein amounts on western blot analysis), and two patients were homozygous for nonsense mutations. In addition, a duplication of one base pair was found in a patient who also harboured a splice site mutation. Another splice site mutation led to the activation of a cryptic splice site, shown by cDNA analysis. All patients reported until now with at least one missense mutation have had the milder type A form of PC deficiency. We thus report for the first time two patients with homozygous missense mutations with the severe type B deficiency, clinically indistinguishable from other patients with type B form of PC deficiency. The mutations found here are novel; it is noteworthy that four Turkish patients did not have any mutations in common, despite the rarity of PC deficiency. There is thus no evidence for recurrent mutations in the Turkish or other populations.
  • Küçük Resim
    Öğe
    Phenotypic and genotypic spectrum of Turkish patients with isovaleric acidemia
    (Elsevier, 2014) Ozgul, Riza Koksal; Karaca, Mehmet; Kilic, Mustafa; Kucuk, Ozgul; Yucel-Yilmaz, Didem; Unal, Ozlem; Dursun, Ali
    We aim to investigate the genetic basis of isovaleryl-CoA dehydrogenase (IVD) gene mutations and genotype-phenotype correlations in Turkish patients. Accordingly, bi-directional sequencing was performed to screen 26 patients with isovaleric acidemia (IVA). Nine novels (c.145delC, c.234 + 3G > C, c.506_507insT, p.Glu85Gln, p.Met147Val, p.Ala268Val, p.Ile287Met, p.Gly346Asp and p.Arg382Trp) and six previously reported (c.456 + 2T > C, p.Arg21His, p.Arg21Pro, p.Arg363Cys, p.Arg363His p.Glu379Lys) pathogenic mutations were identified. Pathogenicity of the novel mutations was supported using computational programs. No clear genotype-phenotype correlation could be determined. One of the cases with the novel c.234 + 3G > C mutation has portoseptal liver fibrosis, the clinical condition that was first reported for IVA. This study is the first comprehensive report from Turkey related to IVA genetics that provides information about the high number of disease-causing novel mutations. (C) 2014 Elsevier Masson SAS. All rights reserved.