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    Öğe
    The Prognostic Importance of Tumor Budding in Intestinal-Type Gastric Adenocarcinoma
    (2022) Sanioğlu, Gökçe; Bostancı, Mustafa Taner; Yörübulut, Serap; Türkmenoğlu, Tuğba Taşkın; Öztürk, Gulfidan; Duzkale, Neslihan
    Aim: Gastric cancer is one of the leading causes of cancer-related deaths. Tumor budding has been\rshown to be a prognostic factor in many cancers. In this study, we aimed to evaluate the prognostic\rsignificance of tumor budding in intestinal-type gastric adenoc arcinoma.\rPatients and Method: A total of 152 cases diagnosed as intestinal type gastric adenocarcinoma in\rthe Pathology Clinic between 2015 and 2021 were included in the study. Tumor budding was grouped\ras low, medium and high. Hematoxylin and eosin-stained slides were re-evaluated in terms of tumor\rdifferentiation, lymphovascular invasion (LVI), perineural invasion (PNI), lymph node involvement, depth\rof invasion (pT) and tumor budding.\rResults: Tumor budding was low in 30.9% (n=47) of the subjects included in the study, moderate in 37.5%\r(n=57) and high in 31.4% (n=48). Statistically, as tumor budding increased, tumor size increased (p<0,05),\rfollow-up times were shortened, survival time (p<0,05), and tumor differentiation (p<0,05) decreased. A\rstatistically significant correlation was observed between tumor budding and LVI (p<0,05), PNI (p<0,05),\rpT(p<0,05), lymph node involvement(p<0,05), and mortality of the cases (p<0,05). No statistically\rsignificant correlation was observed between tumor budding and gender, age, tumor localization and\roperation type (p>0.05).\rConclusion: Tumor budding is associated with poor prognostic factors. As it may be important to guide the\rtreatment modality and follow-up, tumor budding status may be m entioned in routine pathology reports.
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    Öğe
    The relationship between mutation carriage of BRCA1/2 and clinicopathological characteristics in women with breast cancer – experience from a diagnostic centre in Turkey
    (Termedia Publishing House Ltd., 2024) Duzkale, Neslihan; Guler, Onur Can; Kutun, Suat; Emiroglu, Canan; Saridemir, Serdar; Gokce, Aysun; Kandemir, Olcay
    The 5–10% of breast cancers (BC) are hereditary, and BRCA1/2 are causative in 25% of those inherited. It was aimed to examine the BRCA1/2 genotype-BC phenotype relationship. In 170 female patients with BC, BRCA1/2 genes were investigated using Next Generation Sequencing. Demographic and clinicopathological characteristics of the patients and correlations of pedigree analysis with BRCA1/2 mutation status were analysed. BRCA1/2 carriage was found to be 9.4%. When the patients were grouped as ? 40 and > 40 according to the age at diagnosis of BC, the tumour grade was higher in the ? 40 groups. In the study, BRCA1/2 carriage and tumour grade were higher in patients with triple-negative breast cancers (TNBC). The risk of TNBC was 5.560 times higher in BRCA1/2 carriers than in non-carriers. There is a significant relationship between BRCA1/2 carrier and BC hormone receptor negativity, tumour grade, and BC diagnosis age. © 2024, Termedia Publishing House Ltd.. All rights reserved.