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    Erratum to “IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper” [World Allergy Organ J 13/2 (2020) 100080] (World Allergy Organization Journal (2020) 13(2), (S1939455119312360), (10.1016/j.waojou.2019.100080))
    (Elsevier Inc., 2021) Ansotegui, Ignacio J.; Melioli, Giovanni; Canonica, Giorgio Walter; Caraballo, Luis; Villa, Elisa; Ebisawa, Motohiro; Passalacqua, Giovanni
    The publisher regrets we have been made aware of the below errors: 1) In Table 15, row NOVEOS chemiluminescent assay is written “utilizes 40 ?L (0.04 ml) of sample per result”. The correct value would be “4 ?L (0.004 ml)" of sample per result.2) In Table 16, is written “NOVEOS menu has 79 available allergens, consisting of 69 extracts and 10 molecular allergens”. It should say “NOVEOS menu continues to increase and it has 152 total allergens with 108 extracts and 44 components".3) In Table 15, row “Euroimmun”, column “Patient's serum”, is written “1000 ml”. The correct value would be “0.1 ml (-0.4 ml)”.The publisher would like to apologise for any inconvenience caused. © 2021 The Author(s)
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    IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper
    (Elsevier, 2020) Ansotegui, Ignacio J.; Melioli, Giovanni; Canonica, Giorgio Walter; Caraballo, Luis; Villa, Elisa; Ebisawa, Motohiro; Zuberbier, Torsten
    Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.
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    IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper (vol 12, 100080, 2020)
    (Elsevier, 2021) Ansotegui, Ignacio J.; Melioli, Giovanni; Canonica, Giorgio Walter; Caraballo, Luis; Villa, Elisa; Ebisawa, Motohiro; Passalacqua, Giovanni
    [Abstract No tAvailable]
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    Managing anaphylaxis in the office setting
    (Sage Publications Inc, 2016) Cingi, Cemal; Wallace, Dana; Muluk, Nuray Bayar; Ebisawa, Motohiro; Castells, Mariana; Sahin, Ethem; Altintoprak, Niyazi
    Background: Although the definition of anaphylaxis for clinical use may vary by professional health care organizations and individuals, the definition consistently includes the concepts of a serious, generalized or systemic, allergic or hypersensitivity reaction that can be life-threatening or even fatal. Methods: In this review, we presented the important topics in the treatment of anaphylaxis in the office setting. This review will discuss triggers and risk factors, clinical diagnosis, and management of anaphylaxis in the office setting. Results: Anaphylaxis in the office setting is a medical emergency. It, therefore, is important to prepare for it, to have a posted, written anaphylaxis emergency protocol, and to rehearse the plan regularly. In this review, we presented the important steps in managing anaphylaxis in the office. Treatment of anaphylaxis should start with epinephrine administered intramuscularly at the first sign of anaphylaxis. Oxygen and intravenous fluids may be needed for moderate-to-severe anaphylaxis or anaphylaxis that is quickly developing or if the patient is unresponsive to the first injection of epinephrine. Antihistamine therapy is considered adjunctive to epinephrine, which mainly relieves itching and urticaria. Corticosteroids, with an onset of action of 4-6 hours, have no immediate effect on anaphylaxis. Conclusion: To prevent near-fatal and fatal reactions from anaphylaxis, the patient, the family, and the physician must remember to follow the necessary steps when treating anaphylaxis. In anaphylaxis, there is no absolute contraindication for epinephrine.