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Öğe A Case of COVID-19 in a Patient with Pemphigus Successfully Managed with Favipiravir(Duzce Univ, Fac Medicine, 2021) Demirbaş, Abdullah; Elmas, Ömer Faruk; Supsup, Mustafa Atasoy; Demirbaş, Gözde Ulutaş; Tursen Ümit; Lotti, Torello; Kilitci, AsumanCOVID-19 is not only a respiratory disease, but a multisystem disease that can cause organ dysfunction and coagulation disorder associated with high mortality and morbidity, particularly in vulnerable populations. Severe complications can be seen especially in elderly patients with systemic disease and immunosuppressive patients. We present the case of COVID-19 that developed in a 38-year-old female patient with pemphigus successfully managed with favipiravir.Öğe A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase(Tubitak Scientific & Technological Research Council Turkey, 2021) İlanbey, Bilal; Elmas, Ömer Faruk; Sözmen, Eser Yıldırım; Günay, Umran; Demirbaş, Abdullah; Atasoy, Mustafa; Tursen, ÜmitBackground/aim: Chitotriosidase (ChT) is an enzyme secreted by activated macrophages and neutrophils in response to proinflammatory signals. There is growing evidence indicating that ChT activity reflects the systemic inflammatory status. This study aimed to investigate whether serum ChT activity increased in patients with psoriasis and related comorbidities. Materials and methods: This cross-sectional study included 53 (28 with associated comorbidities and 25 without comorbidities) patients with psoriasis and 52 healthy volunteers. All participants underwent laboratory investigations for serum ChT levels, complete blood count, erythrocyte sedimentation rate, C-reactive protein, and serum lipid levels. Results: The patients with psoriasis showed significantly higher levels of ChT activity as compared to the healthy controls (23.5 +/- 11.4 vs. 17.5 +/- 10.4 mu mol/mL/hour; p = 0.015). Additionally, the ChT activity was significantly higher in patients with comorbidities than in those without (p = 0.042). Conclusion: Our data support the pathogenetic role of inflammatory processes induced by macrophage activation in patients with psoriasis and related comorbidities. We believe that high ChT activity in patients with psoriasis may serve as an early prediction of the possible related comorbidities.Öğe Benign Neoplasms(CRC Press, 2022) Demirbaş, Abdullah; Elmas, Ömer Faruk; Akdeniz, NecmettinMost benign cutaneous neoplasms can be diagnosed clinically. If the diagnosis is uncertain clinically, especially when there have been unexpected changes in the appearance of the lesion, a biopsy is indicated. Lesions are small hyperpigmented macules with a diameter generally not exceeding 5 mm. The melanotic macule is a benign hyperpigmentation of mucous membranes found in about 3% of the general population. There is an increase in focal melanin accumulation without an increase in melanocytes. The most important differential diagnosis of acquired melanocytic lesions is melanoma. Histologically, lesions differ from melanoma by having small nucleolus of the melanocytes, absence of atypical mitoses, uniformity of cells, normal maturation, and nesting. Destructive methods, such as cryotherapy, curettage, laser, shave excision, electrocautery, and chemical peels, can be performed for aesthetic purposes. Moles are a common finding that require intervention only when there is concern for a malignancy or when they are cosmetically unacceptable. © 2022 Taylor & Francis Group, LLC.Öğe Calcinosis Cutis in Association With Long-term Stasis After Electrical Burn Injury: a Case Report(Mattioli 1885, 2022) Uyar, Belkiz; Elmas, Ömer Faruk; Acar, Emine Müge; Has, Sümeyra[No abstract available]Öğe Clinical, Demographic and Treatment Characteristics of Pediatric Psoriasis: A Multicenter Study of 150 Patients(Galenos Publ House, 2021) Demirbaş, Abdullah; Özyurt, Kemal; Elmas, Ömer Faruk; Metin, Mahmut Sami; Atasoy, Mustafa; Türsen, Ümit; Kilitci, AsumanBACKGROUND/AIMS: Many studies have focused on the epidemiological features of adult and childhood psoriasis. However, only a few studies have been conducted to demonstrate the clinical and demographic characteristics of pediatric psoriasis in Turkey. This study aimed to determine clinical, demographic, and treatment characteristics of childhood psoriasis in a multicenter series. MATERIALS and METHODS: This study was conducted in four different centers that are located in four cities of Turkey between June 2016 and June 2020. The demographic parameters, possible triggering factors (emotional stress, physical trauma, infection, and medication), and clinical characteristics (psoriasis type, psoriasis area severity index, involved areas, nail involvement, joint involvement, subjective symptoms, disease duration, last treatments and duration of use, and history of accompanying diseases) of pediatric patients with psoriasis were retrospectively analyzed. RESULTS: A total of 150 patients from four different centers were enrolled in the study, of whom 71 (47.30%) were males and 79 (52.70%) were females, with a mean age of 13.71 +/- 42 years (age range: 1-18 years). A family history of psoriasis was determined in 20 (13.33%) patients. Possible triggering factors included emotional stress (n=90, 60%), physical trauma (n=21, 14%), infection (n=14, 9.33%), and medication (n=1, 1.67%). The most common area of involvement was the trunk (n=69, 46%) followed by the scalp (n=42, 28%), hand (n=20, 13.33%), and face (n=19, 12.67%). The prevalence of clinical types was as follows: plaque (n=125,83.33%), guttate (n=10, 6.67%), palmoplantar (n=7, 4.67%), inverse (n=6, 4%), and pustular (n=2, 1.33%) psoriasis. Nail and joint involvement were observed in 30 (20%) and 15 (10%) patients, respectively. The last treatments received included topical treatment (n=101, 67.33%), phototherapy (n=23, 15.33%), acitretin (n=16,10.67%), methotrexate (n=9, 6%), and cyclosporine (n=1, 0.67%). CONCLUSION: In our cohort, the clinical types and treatments used for childhood psoriasis were similar to those of other studies, but the rate of family history was lower, whereas the incidence of emotional stress was higher. Addressing the psychological impacts of psoriasis along with its physical aspects may provide better treatment outcomes.Öğe Melanocytes as the source of the increased melanisation in pigmented epithelial tumours: a holistic approach(Tubitak Scientific & Technological Research Council Turkey, 2022) Kilitci, Asuman; Elmas, Ömer Faruk; Akdeniz, Necmettin; Gamsizkan, MehmetBackground/aim: We aimed to elucidate the causes of the increased melanisation in basal cell carcinoma (BCC) and seborrheic keratosis (SK), and the role of melanocytes in this process. Materials and methods: This study was a retrospective-cohort study conducted in the pathology department of a university hospital between January 2019 and October 2020. Forty-nine SK and 30 pigmented BCC were included in our study. SRY-box transcription factor 10 (SOX10), CD68, and Masson???Fontana staining was used for analysis in all samples. A representative section of each specimen was photographed under ??400 magnification to facilitate the assessments of the morphology of the melanocytes and their following morphometric parameters: density, nuclear diameter, and distribution. The density of pigmented keratinocytes in the lesional epidermis was scored. The nuclear diameters of melanocytes located in the nonlesional epidermis, the density of the melanophages, and the presence or absence of ulceration and solar elastosis were also recorded. Results: The morphometric findings confirmed a statistically significant increase in melanocyte density in the BCC group compared with that in the SK group (p < 0.001). Moreover, the nuclear minor diameters in the melanocytes of the BCC sections were significantly higher than those in the SK specimens (p < 0.001). The epidermal melanocytes were distributed diffusely in almost all BCC specimens (96.7%), whereas they were mainly limited to the basal layer in the majority of the SK sections (59.2%). The number of epidermal melanised keratinocytes with a score of 3 was significantly higher in the SK group (n = 31; 63.2%) than in the BCC group (n = 6; 20%) (p = 0.001), and they were the main cells representing the pigmented appearance of the tumours. No significant difference was found between both tumour groups in terms of their melanophage density scores (p = 0.206). Conclusion: This study is the first step towards an objective quantification of the melanocytes in pigmented epithelial tumours and may provide a morphological background for future studies on these skin lesions.Öğe Potential utility of oral mucosal capillaroscopy as an indicator of microvascular damage in Behçet disease: A preliminary study(Mattioli 1885, 2021) Demirbaş, Abdullah; Elmas, Ömer Faruk; Demirbaş, Gözde Ulutaş; Atasoy, Mustafa; Türsen, Ümit; Lotti, TorelloIntroduction: Behçet disease (BD) is an auto-inflammatory condition characterized by multisystemic vasculitis. Oral mucosal capillaroscopy is an easy-to-use, repeatable, non-invasive method for evaluating mucosal microvasculature, contributing to the differential diagnosis and prognosis of various acute and chronic inflammatory diseases. Objectives: This study aims to characterize and describe the oral labial mucosal capillary findings in patients with BD using handheld dermatoscopy and to investigate the relationship between the capillary findings and the severity of the disease. Methods: This cross-sectional study included patients with BD and healthy subjects. Capillaroscopic examination of the oral labial mucosa in each subject was performed by a handheld dermatoscope using polarized light. The clinical severity of BD was evaluated using Krause's Clinical Severity Scoring for BD. Results: Sixty patients with BD and 60 healthy subjects were enrolled in the study. The frequencies of irregular capillaries, microhemorrhages, glomerular vessels, megacapillaries, and tortuous vessels were statistically significantly higher in the patient group when compared to the healthy individuals. In addition, a correlation was detected between the oral mucosal capillaroscopic findings and disease duration, severity, and vascular complications. Conclusions: Our study is the first to explore the potential role of oral mucosal capillaroscopic examination in patients with BD. Data obtained from this study indicated that oral mucosal capillaroscopy may be a useful tool to demonstrate microvascular damage in patients with BD. © 2021 Demirbaş et al.Öğe Relationship between rosacea and chronic obstructive pulmonary disease: Rosacea and comorbidities(John Wiley and Sons Inc, 2022) Demirbaş, Abdullah; Yümer, Yusuf; Elmas, Ömer Faruk; Ulutaş Demirbaş, Gözde; Atasoy, Mustafa; Türsen, Ümit; Dursun, RecepBackground: Rosacea is a chronic inflammatory skin disease that has been reported to be associated with many systemic disorders including respiratory diseases. Aims: This study aims to investigate respiratory function in patients with rosacea. Patients/Methods: Patients with rosacea and age- and gender-matched healthy volunteers were included in this cross-sectional study. Spirometric pulmonary function tests including the percentage of forced vital capacity (FVC%), percentage of forced expiratory volume in one second (FEV 1%), forced expiratory flow at 25–75% of FVC (FEF 25–75%), and FEV 1/FVC ratio was assessed in both patient and controls. The potential relationship between rosacea severity and pulmonary functions was assessed. Results: A total of 120 patients with rosacea and 120 healthy controls were enrolled in the study. Compared to the controls, FEV 1%, FEV 1/FVC%, and FEF 25–75% values were significantly lower in patients with rosacea. Lower FEV 1/FVC% values were found to be associated with disease severity. FEV 1%, FEV 1/FVC%, and FEF 25–75% values were found to be more useful in differentiating the patients from healthy subjects. Conclusions: This study showed that patients with rosacea may have abnormal respiratory function compared to healthy subjects. Besides, disease severity was associated with worse respiratory functions. We believe that patients with rosacea, particularly those with additional risk factors, should be screened for respiratory disorders. © 2021 Wiley Periodicals LLC.Öğe Survival of biological therapeutics in psoriasis: retrospective analysis of 3-years data in a Turkish registry, PSORTAKSIS(Tubitak Scientific & Technological Research Council Turkey, 2022) Özyurt, Kemal; Zararsız, Gökmen; Ertaş, Ragıp; Cephe, Ahu; Kutlu, Ömer; Elmas, Ömer Faruk; Akkuş, Muhammet ReşatBackground/aim: PSORTAKSIS is a psoriasis registry, which is used for follow-up of patients in Kayseri City Education and Research Hospital, Dermatology Clinic since 2016 in Turkey. PSORTAKSIS includes demographic data, follow-up clinical findings, laboratory output, and treatment information of patients. Here, drug survivals of biologic therapeutics (BT) according to three-year data of PSORTAKSIS will be presented. Materials and methods: Drug survival of BT in PSORTAKSIS was analyzed from 2016 to March 2019. Results: 158 patients (111 of them BT-naive) with psoriasis under BT were enrolled in the current study. Drug survival analysis of patients with ongoing BT (158 treatment periods) revealed mean survival time as 15.49 months for ustekinumab, 15.37 months for adalimumab, 14.00 months for etanercept, 5 months for infliximab, and 4.59 months for secukinumab. The differences between drug survivals of BT were statistically significant (log-rank test, chi(2) = 79.915, p < 0.0001). Age of onset was found to be the only independent risk factor of drug survival according to regression analysis (p = 0.029). Conclusion: As a conclusion, drug survival of UST was significantly higher than that of TNF-alpha inhibitors and SEC in the treatment of psoriasis. This study revealed that among predictors, age at disease onset may influence drug survival.Öğe The potential role of human HIV-1 TAT-Interactive Protein 2 levels in the pathogenesis of contact dermatitis(Tubitak Scientific & Technological Research Council Turkey, 2021) Metin, Mahmut Sami; Bilen, Handan; Elmas, Ömer Faruk; Akdeniz, NecmettinBackground/aim: Human HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is a gene that is extensively expressed in human tissues as well as in tumor tissues. This study aimed to explore the potential role of HTATIP2/TIP30 in contact dermatitis (CD), which is one of the most common inflammatory cutaneous conditions. Materials and methods: This cross-sectional study involved adult patients with acute contact dermatitis who were admitted to the outpatient dermatology clinic of a tertiary hospital and healthy adult volunteers without any cutaneous or systemic diseases. The blood concentration of HTATIP2/TIP30 was measured using ELISA kits. Results: The research sample consisted of 31 patients with CD (18 males, 13 females) and 20 healthy control subjects (14 males, 6 females). The mean ages of the patients with CD and healthy volunteers were 37 and 30 years, respectively (p > 0.05). The mean value of serum HTATIP2/TIP30 levels in patients with CD was 1.65 ng ml-1, which is 0.60 ng ml-1 in the control group (p = 0.02) Conclusion: In this study, serum levels of HTATIP2/TIP30 were statistically significantly higher in patients with CD when compared to healthy controls. This outcome may indicate possible role of HTATIP2/TIP30 in the pathogenesis of CD.Öğe The role of dermoscopy in diagnosis: A case presentation of pseudoxanthoma elasticum initially misdiagnosed as pigmented contact dermatitis(Mattioli 1885, 2021) Elmas, Ömer Faruk; Demirbaş, Abdullah; Kılıç, Raşit; Kilitçi, Asuman[No abstract available]
