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Öğe Altered trigeminal system excitability in menstrual migraine patients(Springeropen, 2009) Varlıbaş, Ayhan; Erdemoğlu, A. KemalTo evaluate brainstem excitability in menstrual migraine (MM) patients and compare the electrophysiological parameters of the trigeminocervical reflex (TCR) during the perimenstrual (headache period) and follicular (headache-free) periods with those in healthy controls. Thirty-one patients with MM and 22 volunteer age- and sex-matched healthy women were included in the study. The TCR was studied bilaterally with stimulation of the supraorbital branch of the trigeminal nerve during the perimenstrual period and follicular phase. The electrophysiological parameters of the TCR were compared between MM patients and controls. In controls, there was no statistically significant difference in the mean reflex latencies recorded during the perimenstrual and follicular phases (P > 0.05). In MM patients, the mean reflex latencies recorded during the perimenstrual (headache period) and follicular phase (headache-free) periods were significantly different from each other and from those in controls. The latencies of MM patients during the follicular (headache-free) period were significantly longer than those of controls. Brainstem excitability differed significantly between the perimenstrual (headache period) and follicular phase (headache-free) periods in MM. Furthermore, trigeminal excitability in MM patients was significantly different from that in healthy controls in both phases of the menstrual period.Öğe Effectiveness of oxcarbazepine in symptomatic treatment of painful diabetic neuropathy(Neurol Soc India, 2006) Erdemoğlu, A. Kemal; Varlıbaş, AyhanBackground: Both basic and clinical research has demonstrated that antiepileptic drugs can be effective in alleviating neuropathic pain. It was hypothesized that oxcarbazepine might be effective in reducing the symptoms of painful diabetic neuropathy. Aims: To investigate the long-term efficacy and safety of oxcarbazepine in symptoms of painful diabetic neuropathy. Materials and Methods: This study included thirty-eight painful diabetic neuropathy patients, which were screened with clinical assessment and electrophysiological studies. The efficacy and safety of oxcarbazepine were evaluated according to the changes in pain intensity and social interference subitems scores of Short-form Brief Pain Inventory besides electrophysiological studies at the end of six months of the treatment. Statistical Analysis: The Students t, Mann-Whitney U and Rank Sum test and Chi-square tests were applied to examine variables differences. The level of statistical significance was chosen to be P<0.05. Results: A significant difference was found in all of subitems of pain intensity and social interference at the end of the study according to the baseline scores. Improvement was observed in 52.7%, 63.1%, 55.3% and 63.2% of patients for worst, least, average and pain right now at the end of six months, respectively. Improvement was observed as 60.6%, 63.2%, 52.6%, 60.5%, 68.4% and 63.2% for general activity, mood, walk, work, people relations, sleep and life enjoyment subitems, respectively. None of these patients had any prominent side effect leading to discontinue the treatment. Conclusion: Long-term oxcarbazepine treatment was found to be effective and safe in the symptoms of painful diabetic neuropathy.Öğe Effectiveness of oxcarbazepine in symptomatic treatment of painful diabetic neuropathy: an open label prospective trial(Elsevier Science Bv, 2005) Erdemoğlu, A. Kemal; Varlıbaş, Ayhan…Öğe The efficacy and safety of gabapentin in carpal tunnel patients: Open label trial(Medknow Publications, 2009) Erdemoğlu, A. KemalBackground: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by median nerve compression at the wrist. It results in loss of considerable man days and the effectiveness the various treatment modalities are still debated. Aim: To study the efficacy of gabapentin in patients with CTS. The study aim is to investigate the efficacy of gabapentin in patients with CTS patients who were refractory to the other conservative measures or unwilling for the surgical procedure. Materials and Methods: Forty one patients diagnosed as idiopathic CTS were included in the study. Patients were assessed with symptom severity scale (SSS) and functional status scale (FSS) scores of Boston Carpal Tunnel Questionnaire (BCTQ) before and at 1, 3, and 6 months of the treatment. Response to therapy was determined by using SSS and FSS scores of BCTQ. Results: The median dosage of gabapentin was 1800 mg/daily. Side effects were mild and transient. There was a statistically significant difference in both symptom SSS and FSS scores between before and after treatment in patient groups at the end of six months (P < 0.001). According to grading the changes in subscales of BCTQ, of 41 patients, 34.1 and 29.3 had a >= 40 decrease in SSS and FSS, respectively. Conclusion: Gabapentin was found to be partially effective and safe in symptomatic treatment of CTS patients.Öğe Kan glukoz, HbA1C, kortizol düzeyi ve strokun erken prognozu arasındaki ilişki(1999) Erdemoğlu, A. Kemal; Özbakır, ŞenayAmaç: Stroklu hastalarda kan glukoz ve kortizol düzeyleri ile strokun lezyon tipi, şiddeti, prognozu ve nörolojik iyileşmesi arasındaki ilişkinin incelenmesi amacıyla planlandı. Metod ve Materyal: 51 akut iskemik veya hemorajik stroklu hasta prospektif olarak çalışmaya alındı. GİA, subaraknoid kanamalı ve bilgi alınamayan hastalar çalışma grubu dışında tutuldu. Sonuç: Hiperglisemik diabetik olmayan ve diabetik hastalarda, sağ kalım oranı normoglisemik hastalardan anlamlı olarak daha düşüktü. Yüksek serum kortizol düzeyi, hiperglisemik diabetik olmayan, diabetik, klinik durumu kötüleşen ve exitus olan hastalarda yüksek olarak tespit edildi. Strokun natürü, lezyonun büyüklüğü ve arter alanı incelendiğinde başvuru ortalama kan glukoz ve kortizol düzeyinde farklılık saptanmadı. HbA1c düzeyi ile klinik durumun ağırlığı ve sağkalım arasında ilişki saptanmadı. Başvuru değerlendirmesinde şiddetli nörolojik defisit en sık hiperglisemik diabetik olmayan grupta gözlendi. Strok sonrası nörolojik iyileşmenin, normoglisemik diabetik olmayan hastalarda diğer gruplardan belirgin olarak daha iyi olduğu saptandı. Lezyon genişliği ve strok risk faktörlerinde gruplar arasında farklılık saptanmadı. Sonuç: Sonuç olarak akut hipergliseminin diabetik hastalarda nondiabetik hastalardan daha fazla zarar verici olduğu kabul edilebilir. Bu sebeple strok sonrası prognozu olumsuz yönde etkileyen bir faktör olduğu ve hastaların tedavilerinin ve takiplerinde bu durumun göz önüne alınması gerektiği görüşündeyiz.
