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Öğe Arnold-Chiari malformation presenting with recurrent syncope attacks(Wiley-Blackwell, 2012) Gokce, B.; Erdemoglu, A. K.…Öğe Brief Pain Inventory score identifying and discriminating neuropathic and nociceptive pain(Wiley, 2013) Erdemoglu, A. K.; Koc, R.ObjectiveThe aim of this study was to evaluate the psychometric properties of the Brief Pain Inventory (BPI) as well as tests of its reliability, validity, and discriminative utility for estimating the status of chronic pain in neuropathic and nociceptive pain patients. Method and patientsWe enrolled 224 chronic pain (126 neuropathic pain and 98 nociceptive pain) patients. The original version of the BPI was translated into Turkish by standard procedures. An independent clinician determined the pain type. The factor analysis, reliability (internal consistency and test-retest reliability), and validity (agreement with the reference diagnosis and sensitivity, specificity, and positive and negative predictive values) were determined. Discriminant function analysis was then employed to determine whether BPI could differentiate between neuropathic and nociceptive pain. ResultsCronbach's -coefficient was 0.84 for the test and 0.83 for the retest. BPI scores for subjects did not significantly differ between applications r:0.96 (P<0.01). Principal axis factoring with oblimin rotation revealed three interpretable factors: severity scale, activity interference, and sleep and mood interference. Compared to the clinical assessment, sensitivity, specificity, and positive and negative predictive values for criterion total BPI score were 79.37%, 46.9%, 65.8%, and 63.9%, respectively. ConclusionThe results suggest that Turkish version of BPI is a reliable and valid evaluation measure of neuropathic and nociceptive pain patients. This is the first study reporting the comparison and validation of psychometric properties of BPI in neuropathic and nociceptive pain group. Our data suggest that BPI may able to discriminate the origin of chronic pain.Öğe Evaluation of oxidative stress markers and antioxidant status in dementia and Parkinson disease(Wiley-Blackwell, 2011) Gonenc, A.; Hacisevki, A.; Erdemoglu, A. K.; Dagkiran, E.; Torun, M.…Öğe Evaluation Of Oxidative Stress Markers And Antioxidant Status In The Alzheimer Disease, Vascular Dementia And The Parkinson Disease(Scibulcom Ltd, 2013) Gonenc, A.; Hacisevki, A.; Erdemoglu, A. K.; Dagkiran, M. E.; Torun, M.Oxidative stress may be involved in pathogenesis of neurodegenerative diseases. We aimed to measure MDA, NO, 8-OHdG and TAC, SOD and CAT levels in the Alzheimer disease, Parkinson disease and vascular dementia, and evaluate oxidant and antioxidant status in these diseases. Oxidative stress parameters were measured in 20 patients with vascular dementia, 20 patients with the Alzheimer disease, 20 patients with the Parkinson disease and 20 matching controls. MDA, NO and TAC were assayed with spectrophotometric methods. 8-OHdG was quantitated by the Elisa method. SOD and CAT were assayed with colorimetric methods. MDA, NO, 8-OHdG and SOD levels in total patient group were higher (p = 0.039, 0.041, 0.021 and 0.045, respectively), while TAC levels were lower (p = 0.010) as compared with controls. When compared to controls, the following were higher: MDA in the Parkinson disease (p = 0.036); NO in the Alzheimer disease (p = 0.028). However, TAC in the Alzheimer disease (p = 0.024) were lower. We observed negative correlations between TAC and MDA in the Parkinson disease (r = -0.496, p = 0.026); between SOD and 8-OHdG in the Alzheimer disease (r = 0.526, p = 0.017). These findings support the idea that the oxidative stress may play an important role in the pathogenesis of neurodegenerative diseases. This preliminary study shows an increase in free radical production in the Alzheimer disease and Parkinson disease. Also, there is a defect in the antioxidant defense system, which may lead to oxidative damage in patients with the Alzheimer disease.Öğe Fatigue and excessive daytime sleepiness in migraine patients compared to controls(Wiley-Blackwell, 2008) Doner, H.; Erdemoglu, A. K.…Öğe Greater occipital nerve blockade for the treatment of chronic migraine: a randomized, multicenter, double-blind, and placebo-controlled study(Wiley, 2015) Inan, L. E.; Inan, N.; Karadas, O.; Gul, H. L.; Erdemoglu, A. K.; Turkel, Y.; Akyol, A.ObjectivesWe aimed to assess the efficacy of greater occipital nerve (GON) blockade at chronic migraine (CM) treatment. Materials and methodsPatients with CM were randomly divided into two groups of 42. GON blockade was administered four times (once per week) with saline in group A or bupivacaine in group B. After 4weeks of treatment, blinding was removed; in group A, GON blockade was achieved using bupivacaine, while group B continued to receive bupivacaine, and blockade was administered once per month, then followed for 2months. Primary endpoint was the difference in number of headache days, duration of headache, and pain scores. ResultsSeventy-two of 84 patients completed the study. After 1month of treatment, number of headache days had decreased from 16.95.7 to 13.2 +/- 6.7 in group A (P=0.035) and from 18.1 +/- 5.3 to 8.8 +/- 4.8 in group B (P<0.001), (P=0.004, between groups); duration of headache (hour) had decreased from 24.2 +/- 13.7 to 21.2 +/- 13.4 in group A (P=0.223) and from 25.9 +/- 16.3 to 19.3 +/- 11.5 in group B (P<0.001), (P=0.767, between groups). VAS score decreased from 8.1 +/- 0.9 to 6.7 +/- 1.6 in group A (P=0.002) and from 8.4 +/- 1.5 to 5.3 +/- 2.1 in group B (P<0.001), (P=0.004, between groups). After blinding was removed (in 2nd and 3rd month), group A exhibited similar results like group B in 3rd month. ConclusionsOur results suggest that GON blockade with bupivacaine was superior to placebo and was found to be effective, safe, and cost-effective for the treatment of CM. According to our knowledge, this is the first randomized, multicentre, double-blind, and placebo-controlled study in the literature in this field of work.Öğe Greater occipital nerve blocks with bupivacaine in the treatment of chronic migraine. Randomized, multicenter, double-blind, parallel, placebo-controlled study(Wiley-Blackwell, 2014) Inan, L.; Inan, N.; Karadas, O.; Gul, H. L.; Erdemoglu, A. K.; Turkel, Y.; Akyol, A.[Abstract No tAvailable]Öğe Greater occipital nerve blocks with bupivacaine in the treatment of chronic migraine: randomized, multicenter, double-blind, parallel, placebo-controlled study(Springer Heidelberg, 2014) Inan, L.; Inan, N.; Karadas, O.; Gul, H. L.; Erdemoglu, A. K.; Turkel, Y.; Akyol, A.…Öğe No difference in pain threshold between migraine patients and healthy controls(Wiley-Blackwell, 2012) Gokce, B.; Durusoy, L.; Erdemoglu, A. K.…Öğe The preliminary results of validation of Turkish brief pain inventory in neuropathic and nociceptive patients(Wiley-Blackwell, 2008) Koc, E. R.; Erdemoglu, A. K.…Öğe Surgery of nasal contact point headache: assessment with quality of life(Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2018) Yalcinozan, E. T.; Kazkayasi, M.; Muluk, N. Bayar; Gokce, B.; Erdemoglu, A. K.Objectives: The purpose of this study was to determine the efficiency of surgery in the treatment of referred headaches which might originate from nasal mucosal contact points. Methods: This study involved 20 patients who had complaints of headaches for three months or longer in duration and had nasal mucosal contact points in the physical examination. The patients were examined during the preoperative and postoperative period with nasal endoscopy, topical lidocaine tests, computerized tomography of paranasal sinuses, a visual analogue scale, the short-form 36-item health survey and acoustic rhinometry. The type of surgery required was decided according to the localization of the nasal mucosal contact point. Results: The differences in the comparison of the visual analogue scale scores between the preoperative period after the lidocaine test and the postoperative period of the eighth week and 24th week were statistically significant (p<0.013). The scores of the short-form 36-item health survey from the preoperative period, postoperative eighth week, and postoperative 24th week showed statistically significant differences in a paired comparison test (p<0.017). No statistically significant differences were observed in acoustic rhinometry results between the preoperative period, the postoperative eighth week and the postoperative 24th week. In the first-year period, the visual analogue scale and short-form 36-item health survey scores designated a statistically significant improvement (p>0.05). Conclusions: This study points out the importance of rhinologic surgery for nasal mucosal contact points which might be the cause of referred headaches.
