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    Carotid Artery Dissection and Cerebral Infarction Secondary to Blunt Trauma
    (Turkish Neurological Soc, 2012) Gokce, Burcu; Erdemoglu, A. Kemal
    Traumatic carotid artery dissection may appear after blunt head or neck traumas. Patients can be asymptomatic or clinical symptoms may include headache, transient ischemic attack, stroke, loss of consciousness, hemiparesis, aphasia and Horner syndrome, typically occurring within hours to days. Prognosis is good if diagnosed and treated early. As cerebral ischemia and neurological deficits may develop subsequently, it is essential that carotid artery dissection should be considered, and possible cases evaluated and diagnosed appropriately. In this article, we present a case of internal carotid artery dissection with diagnostic neuro-imaging findings, that occurred after 6 hours of blunt trauma and subsequent cerebral infarction following a car accident. Clinical features, neuro-radiological diagnostic methods and treatments options are discussed with relevant literature.
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    Dorsal Sural Nerve Conduction Study in Early Diabetic Polyneuropathy Patients and Relationship of Adiponectin and High Sensitive-C Reactive Protein Levels
    (Journal Neurological Sciences, 2009) Kokoglu, Fatma; Leventoglu, Alev; Erdemoglu, A. Kemal
    Objective: In this study, we aimed to investigate the change in dorsal sural nerve (DSN) conduction studies in early diabetic neuropathic patients and to evaluate whether high sensitive C-reactive protein (hs-CRP), inflammatory marker, and adiponektin, important role in insulin resistance and diabetes, have any effect on DSN studies or not. Material and Method: Forty-six patients with early stages (Dyck classification N1)diabetic neuropathy and age-sex matched forty-four control subject were included in the study. Informed consent was obtained after approval of ethical committee. In all subject DSN conduction studies were performed with conventional electrophysiological studies. DSN electrophysiological parameters of diabetics were compared with controls. The relationship between plasma adiponectin and hs-CRP levels and DSN conduction study parameters were analyzed. Results: In diabetic patients, DSN parameters were significantly different than controls. The level of adiponectin was found to be lower in diabetic (p:0.01) but not statistically significant for hs-CRP levels (p:0.40). There was not any relationship between DSN parameters and the level of adiponectin or hs-CRP (p>0.05). Sixty-three % of diabetics, whom routine electrophysiological studies were in normal limits, had abnormal DSN parameters. Fifty% of diabetics had bilateral abnormalities. However, there was no difference in hs-CRP and adiponectin levels between patients with abnormal and normal DSN studies (p>0.05). Conclusion: DSN studies are useful methods to detect subclinical early diabetic polyneuropathy according to the results of our study. Although adiponectin level was found lower in early diabetic neuropathic patients, both adiponectin and hs-CRP do not have any relationship with DSN studies.
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    Validity and Reliability of the Turkish Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) Questionnaire
    (Oxford Univ Press, 2010) Koc, Rabia; Erdemoglu, A. Kemal
    Objective. The Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) is a 7-item self-report scale developed to identify pain of predominantly neuropathic origin. The aim of this study was to develop a Turkish version of the S-LANSS and to test its validity and reliability in chronic pain patients. Method and Patients. We enrolled 244 chronic pain patients treated at the Neurology Department. The original version of the S-LANSS was translated into Turkish by standard procedures. An independent clinician determined the pain type (neuropathic vs nociceptive). The reliability (internal consistency and test-retest reliability) and validity (agreement with the reference diagnosis and sensitivity, specificity, and positive and negative predictive values) were determined. Results. Two-hundred and forty-four patients with chronic pain (167 women, 43.1 +/- 11.4 years), 137, neuropathic pain and 107, nociceptive pain, were asked to complete the S-LANSS twice. Cronbach's alpha-coefficient was 0.74 for the test and 0.73 for the retest. Total S-LANSS scores for subjects did not significantly differ between applications (P = 0.46). Correlation coefficient was r: 0.97 (P < 0.01), which is fairly high for a self-assessment tool. Compared with the clinical assessment, the sensitivity and specificity of the S-LANSS were 72.3% (95% CI, 64.0-79.6%) and 80.4% (95% CI, 71.6-87.4%), respectively, for both the test and retest. The sensitivity and specificity of the Turkish S-LANSS were similar to those determined in the original validation study. Conclusion. This study reports the first validation of a translated version of the S-LANNS into another language. The results suggest that the Turkish version of S-LANSS is a reliable and valid differential diagnostic measure of neuropathic pain in chronic pain patients.
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    Validity and Reliability of Turkish Translation of Neuropathic Pain Impact on Quality-of-Life (NePIQoL) Questionnaire
    (Wiley-Blackwell, 2016) Acar, Betul; Turkel, Yakup; Kocak, Orhan M.; Erdemoglu, A. Kemal
    ObjectivesThe aim of this study was to adapt the Neuropathic Pain Impact on Quality-of-Life Questionnaire (NePIQoL) into Turkish and to test its validity and reliability in neuropathic pain patients. MethodsWe enrolled 200 chronic pain patients who admitted to the Neurology Department of Kirikkale University, Faculty of Medicine, in our study. Patients were diagnosed with neuropathic or nociceptive pain based on medical history, physical examination, electromyography and nerve conduction studies, laboratory examinations, and imaging techniques. Discriminant analysis was used to diagnose the neuropathic pain regarding sensitivity and specificity. The original version of the NePIQoL was translated into Turkish by standard procedures. ResultsTotal NePIQoL scores were statistically different between neuropathic and nociceptive pain patients in both the first and second NePIQoL applications (P<0.001). Cronbach's alpha coefficient of total 12 items of the first and second applications was 0.95. These results suggest a high validity level for the Turkish version of the NePIQoL. ConclusionsThe Turkish version of NePIQoL appears to be reliable and valid for neuropathic pain impact on quality of life in patients with neuropathic pain.