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    Citrate levels in fresh tomato juice: A possible dietary alternative to traditional citrate supplementation in stone-forming patients
    (Elsevier Science Inc, 2008) Yilmaz, Erdal; Batislam, Ertan; Basar, Murad; Tuglu, Devrim; Erguder, Imge
    OBJECTIVES To detect citrate levels in fresh tomato juice, to reveal whether it can be studied for prevention of recurrent hypocitraturic nephrolithiasis. METHODS Juices of tomato, orange, lemon, and mandarin were extracted and blended with a hand blender, and 10 samples of 100 mL were taken from each. Citrate, oxalate, calcium, phosphorus, magnesium, sodium, potassium, chloride, and pH levels were examined in these. The same variables were re-evaluated after the samples were stored at +4 degrees C for 1 week. RESULTS In fresh tomato juice, higher citrate and magnesium levels as well as lower sodium and oxalate levels were detected as compared with the other juices. No differences were observed with regard to all variables among fresh orange, lemon, and mandarin juices. The level of citrate in the fresh tomato juice was higher at a statistically significant level than that in tomato juice that was stored for 1 week. The amount of oxalate increased in stored tomato juice. CONCLUSIONS Fresh tomato juice is considered a rich source of citrate. Furthermore, a high level of magnesium and a low level of sodium and oxalate content were detected in fresh tomato juice, the usability of which in recurrent hypocitraturic nephrolithiasis can be investigated in clinical studies.
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    Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study
    (Turkish Soc Cardiology, 2013) Ariturk, Ozlem Karakurt; Ureten, Kemal; Sari, Munevver; Yazihan, Nuray; Ermis, Ezgi; Erguder, Imge
    Objective: There are many studies demonstrating deteriorated ventricle and endothelium functions in familial Mediterranean fever (FMF) patients. As FMF is an autoinflammatory disease with an ongoing inflammatory activity and inflammation plays an important role in the development and progression of atherosclerosis in some of the rheumatic diseases, we aimed to investigate the early markers of atherosclerosis in patients with FMF by the measurements of serum paraoxonase-1 (PON-1) activity mean platelet volume (MPV) and malondialdehyde (MDA) level. Methods: This study is a cross-sectional, observational study. Forty consecutive patients with FMF and twenty healthy volunteers were selected to form the study population. The diagnosis of FMF was based on Tel-Hashomer criteria. Serum PON-1 activity, MPV and MDA level were determined to examine their association with FMF. Student's t-test, Mann-Whitney U test, Pearson correlation analysis were used for statistical analysis. Results: The mean PON-1 activity in FMF patients was significantly lower than in the healthy population (141.46 +/- 38.29 vs. 179.62 +/- 10.73 U/I, p<0.01). Serum MDA levels were the same between the groups (1.08 +/- 0.66 vs. 1.08 +/- 0.33 nmol/mL, p=0.99). MPV was higher in FMF patients than in the control I group (8.87 +/- 0.99 vs. 8.22 +/- 0.45 fl, p=0.04). PUN, MPV and MDA levels were the same in FMF patients with acute attack and attack -free period. Conclusion: Our results show that PON-1 activity is lower in patients with FMF. Reduced PON-1 activity and increased MPV, independent of the oxidative stress status of these patients, may lead to increased atherosclerotic propensity in FMF.