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Öğe BCL-2-related apoptosis markers in cutaneous human papillomavirus-associated lesions(Lippincott Williams & Wilkins, 2004) Erkek, E; Bozdogan, O; Atasoy, P; Birol, A; Kocak, MBackground: Human papilloma virus (HPV) is an etiological agent in benign and malignant epithelial tumors. Resistance to apoptotic stimuli by viral strategies represents an immunologic escape mechanism during virus-induced tumor development and is critical for efficient replication of the virus. Objective: The aim of the present study was to investigate a role of bcl-family proteins in the anti-apoptotic pathways modulated by low-risk HPVs in the development of benign HPV-associated cutaneous tumors. Methods: Forty lesional biopsy specimens from HPV-associated cutaneous lesions and 11 non-lesional control skin biopsies were studied by immunohistochemical analysis for the differential expressions of HPV antigens, the pro-apoptotic bax protein, and the antiapoptotic bcl-2 and bcl-x proteins. Results: Compared with the normal epidermis, bcl-2 and bcl-x expression were significantly reduced in the lesional epidermis. Bax was expressed in HPV-associated cutaneous lesions, although the expression did not reveal a significant deviation from that in normal skin. Conclusion: These findings indicate a discordant expression of bcl2/ bcl-x and bax proteins in HPV-associated skin lesions and suggest that low-risk HPVs mediate other pathways that bypass the action of anti-apoptotic bcl-2 and bcl-x proteins. The presence of bax expression with a prominent decrease in bcl-2/ bax ratio and the lack of massive apoptosis in HPV-associated benign epithelial lesions may imply that interference with the pro-apoptotic proteins of bcl-family may constitute one of the several mechanisms mediated by HPV oncoproteins for the suppression of apoptotic process.Öğe Doxycycline-induced staining of permanent adult dentition(Wiley, 2005) Ayashoglu, E; Erkek, E; Oba, AA; Cebecloglu, EBackground. Doxycycline, is the most, effective antibiotic for managing, brucellosis. Although it is relatively free from side, effects, complications involving the skin, nails-and teeth may rarely be encountered. Methods: Four patients with brucellosis developed yellow-brown discolouration of teeth following a 30-45 day course of doxycycline therapy during summer at a dose of 200mg/day. Results: All four patients were diagnosed as having doxycycline-induced staining of the permanent dentition. In all cases,, the staining completely resolved and the teeth recovered their original colour following abrasive dental cleaning. Conclusions: These observations indicate that the incidence of staining of the permanent dentition, as a complication of doxycycline, may be much higher than the literature indicates, especially if treatment is administered during summer, months. Fortunately, this complication is reversible and does not require termination of. doxycycline therapy. Complete resolution following abrasive cleaning may suggest that an extrinsic mechanism within the dental milieu may be involved in its pathogenesis. Strict avoidance of sunlight exposure during high-dose, long-term doxycycline therapy might prevent the development of this complication.Öğe Evidence of chronic Chlamydia pneumoniae infection in patients with Behcet's disease(Informa Healthcare, 2004) Ayaslioglu, E; Duzgun, N; Erkek, E; Inal, ABehcet's disease is a chronic vasculitis of unknown aetiology. Particular viral and bacterial pathogens have long been suspected of playing a role in the pathogenesis of the disease. Chlamydia pneumoniae is an intracellular bacterium capable of causing chronic infections. Some reports have suggested that the microorganism might be involved in the pathogenesis of vasculitis. The purpose of the present study was to investigate a possible correlation between C. pneumoniae infection and Behcet's disease. For this purpose, 90 consecutive patients with Behcet's disease and 50 healthy controls were enrolled. Immunoglobulin A (IgA) and IgG antibodies to C. pneumoniae were determined by 2 different techniques, namely indirect fluorescent antibody assay (IFA) and enzyme linked immunosorbent assay (ELISA). IgA antibodies to C. pneumoniae were detected in 17 (18.9%) patients with Behcet's disease and in 1 (2%) healthy control by IFA. By ELISA 27 patients (30.0%) and 6 controls (12.0%) had C. pneumoniae IgA. A significant difference was observed for IgA seropositivity between the 2 groups. Although IgG seropositivity between the 2 groups did not differ significantly, the number of individuals with IgG titres of greater than or equal to 1: 1000 was significantly higher in the patient group (43.1%) compared with the control group (13.9%). These finding provide serological evidence of chronic C. pneumoniae infection in association with Behcet's disease.Öğe Gianotti-Crosti syndrome preceded by oral polio vaccine and followed by varicella infection(Blackwell Publishing Inc, 2001) Erkek, E; Senturk, GB; Ozkaya, O; Bukulmez, GGianotti-Crosti syndrome (papular acrodermatitis of childhood) is considered a nonspecific cutaneous host response to a variety of infectious agents, particularly viruses. Herein we report a case of Glanotti-Crosti syndrome preceded by oral polio vaccine and followed by varicella infection. The present case may support the hypothesis of initial Immunization and following viral infection as a possible mechanism for Glanotti-Crosti syndrome.Öğe Juvenile subcorneal pustular dermatosis: A case report(Blackwell Publishing Inc, 2003) Kocak, M; Birol, A; Erkek, E; Bozdogan, O; Atasoy, PSubcorneal pustular dermatosis is a chronic, relapsing, pustular dermatosis that usually develops in elderly women. It is rarely seen in childhood and adolescence. The hallmark of the disease is formation of a subcorneal pustule detected on histopathologic examination. Herein we present a 13-year-old girl diagnosed with subcorneal pustular dermatosis based on the typical clinical and histologic findings. Direct and indirect immunofluorescence and serum protein electrophoresis had negative results. The patient partially recovered after 5 weeks of treatment consisting of oral dapsone and a topical steroid ointment.Öğe Peripheral neuropathy in Behcet's disease(Japanese Dermatolgical Assoc, 2004) Birol, A; Ulkatan, S; Kocak, M; Erkek, EBchcet's disease (BD) is a multisystem disorder. Since its first description, the involvement of many organ-systems has been studied. However, the involvement of the peripheric nervous system has not been well documented yet. Twenty-six patients involved in the study were without prominent complaints of neuropathic symptoms. They were surveyed through the outpatient clinic of the department of dermatology. Each patient filled out a total neuropathy score (TNS) questionaire after their neurologic exam. A neurology specialist conducted the electrophysiological study. Our results were noteworthy because this complication was present without significant complaint. We hypothesized that the nerve dysfunction or peripheral neuropathy of BD is an axonal type of distal polyneuropathy and predominantly involves the lower extremities. We did not find a predominant motor or sensory nerve involvement. This complication is mentioned and reported rarely in BD.Öğe Pigmented terminal hair cysts within an intradermal melanocytic naevus(European Acad Dermatology & Venereology, 2003) Erkek, E; Bozdogan, OThe combination of melanocytic naevi and cysts of adnexal or epithelial origin has been described previously. Herein we describe a case of intradermal melanocytic naevus containing pigmented terminal hair cysts, a rare variant of epithelial cysts. Our observation suggests that pigmented follicular cysts and combined cystic-melanocytic lesions may be attributed to follicular occlusion.Öğe Tetanus antitoxin Seroprevalence in patients with Behget's disease(Informa Healthcare, 2003) Ayaslioglu, E; Erkek, E; Kilic, D; Kaygusuz, S; Karaca, F; Duzgun, NAnti-tetanus antibody status was evaluated by enzyme-linked immunosorbent assay in 82 patients with Behcet's disease and 79 healthy individuals. 76 patients with Behcet's disease (92.7%) and 74 healthy controls (93.7%) had protective antibody titres against tetanus, with geometric mean levels of 1.0194+/-1.2755 and 1.3899+/-1.6533 IU/ml, respectively. The difference between the 2 groups was not statistically significant. There was a significant inverse correlation between antitoxin titres and age in patient and control groups. These findings imply that patients with Behcet's disease have intact overall immunity against tetanus.
