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Öğe Androgen receptor status in lesional and normal skin of patients with rosacea(Blackwell Publishing Ltd, 2004) Erkek, E.; Bozdogan, O.; Kocak, M.; Birol, A.; Atasoy, P.…Öğe Annular verrucous psoriasis with exaggerated papillomatosis(Lippincott Williams & Wilkins, 2001) Erkek, E.; Bozdoğan, O.Psoriasis is a disease of substantial clinical and microscopic diversity. We report a case of annular verrucous psoriasis associated with abnormal papillomatosis, resulting in finger-like projections. We believe that this finding may represent another odd histopathologic feature in psoriasis with verrucous and rupial clinical morphology.Öğe Bcl-2-related proteins, (alpha)-smooth muscle actin and amyloid deposits in aggressive and non-aggressive basal cell carcinomas(Taylor & Francis As, 2002) Bozdoğan, Ö.; Erkek, E.; Atasoy, P.; Koçak, M.; Birol, A.; Caydere, M.Aberrant expression of bcl-gene products has been implicated in the development of non-melanoma skin cancers. Recently, altered expression of alpha-smooth muscle actin has been proposed as predictive of tumour behaviour in basal cell carcinomas. The purpose of this study was to compare the aggressive and non-aggressive basal cell carcinomas in terms of bcl-gene products and alpha-smooth muscle actin expression. Fifty excisional biopsy samples were studied by immunohistochemical technique for the differential expressions of bcl-2, bax, bcl-x and alpha-smooth muscle actin. Bcl-2, bcl-x and bax were expressed in 34 (68%), 38 (76%) and 41 (82%) specimens, respectively. Immunoreactivity for alpha-smooth muscle actin was noted both in tumour nests (64%) and within the stroma (54%). There was a significant difference between aggressive and non-aggressive basal cell carcinomas in terms of bcl-2 and stromal alpha-smooth muscle actin immunoreactivity. Non-aggressive basal cell carcinomas display a concordant expression of bcl-family proteins, whereas aggressive tumours reveal a discordant pattern. An increased expression of stromal alpha-smooth muscle actin with a concomitant decrease or loss of bcl-2 expression may be highly suggestive of aggressiveness in basal cell carcinoma.Öğe A case of cheilitis glandularis superimposed on oral lichen planus: successful palliative treatment with topical tacrolimus and pimecrolimus(Blackwell Publishing, 2007) Erkek, E.; Sahin, S.; Kilic, R.; Erdogan, S.…Öğe Confluent and reticulated papillomatosis: favourable response to low-dose isotretinoin(Wiley, 2009) Erkek, E.; Ayva, S.; Atasoy, P.; Emeksiz, M. C.…Öğe Erythema multiforme associated with acute hepatitis B virus infection(Blackwell Publishing, 2006) Olut, A. I.; Erkek, E.; Özünlü, H.; Özsakarya, F.…Öğe Examination of Bcl-2, Bcl-X and bax protein expression in psoriasis(Blackwell Publishing Ltd, 2003) Koçak, M.; Bozdogan, O.; Erkek, E.; Atasoy, P.; Birol, A.Background Psoriasis is an inflammatory skin disease characterized by epidermal hyperplasia and greatly accelerated epidermal turnover. The blockage of normal apoptotic process in the epidermis is one of the factors implicated in the pathogenesis of psoriasis. Objective The purpose of the present study was to elucidate whether bcl-family proteins are significantly involved in the hypothetical antiapoptotic cascade in lesional psoriatic epidermis. Methods Twenty-six lesional biopsy samples of 26 patients with psoriasis and five control specimens from normal skin were studied by immunohistochemical method for the differential expression of pro-apoptotic bax and antiapoptotic bcl-2 and bcl-x proteins. Results Compared with the normal epidermis, bcl-2 expression was significantly reduced, whereas bax and bcl-x were significantly overexpressed in the psoriatic epidermis. The localization of bcl-2/bax/bcl-x proteins in the psoriatic epidermis did not show a significant deviation from that in the normal epidermis. Conclusion These findings indicate a discordant expression of bcl-2 and bax/bcl-x in psoriatic epidermis. Increased bcl-x expression might contribute to the antiapoptotic response in psoriatic keratinocytes. The presence of strong bax expression with a concomitant decrease in bcl-2 expression suggests either a functional defect in bax protein or an inherent/acquired resistance to bax-mediated apoptosis in psoriatic keratinocytes.Öğe Focal acral hyperkeratosis: A rare cutaneous disorder within the spectrum of costa acrokeratoelastoidosis(Wiley, 2004) Erkek, E.; Kocak, M.; Bozdogan, Ö.; Atasoy, P.; Birol, A.Acrokeratoelastoidosis and focal acral hyperkeratosis share similar clinical features and identical histologic epidermal alterations. These disorders are distinguished solely on the basis of the absence of elastorrhexis in the latter. We present a case of focal acral hyperkeratosis in a 9-year-old girl. The lesions consisted of translucent polygonal papules clustered on the thenar regions of the palms and over the metacarpophalangeal and interphalangeal joints. Histopathologic examination revealed orthohyperkeratosis within focal clavus-like depressions of the epidermis and prominent hypergranulosis. There was no evidence of alterations in elastic tissue. The clinicopathologic distinction between focal acral hyperkeratosis and acrokeratoelastoidosis is blurred. There is enough evidence to consider the former as a histologic variant of Costa acrokeratoelastoidosis syndrome, and a better nomenclature for this disorder would be "acrokeratoelastoidosis without elastorrhexis."Öğe Keloid secondary to therapeutic cupping: an unusual complication(Wiley, 2005) Birol, A.; Erkek, E.; Kurtipek, G. S.; Koçak, M.…Öğe Leptin resistance and genetic predisposition as potential mechanisms in the development of skin tags(Medcom Ltd, 2011) Erkek, E.; Kisa, U.; Bagci, Y.; Sezikli, H.Background and objective: The cause of skin tags (ST) remains elusive. The present study was designed to elucidate the role of leptin and to unravel other potential aetiological factors in the pathogenesis of ST. Methods: The study population comprised 58 patients with ST and 24 control individuals. Demographic and other variables were recorded. A detailed laboratory evaluation including serum leptin was performed. Results: Statistical analysis revealed significant differences between the two groups in terms of body weight, body mass index (BMI), family history of ST, triglyceride, cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and serum leptin levels. A family history of ST was the most important predictor of ST development by logistic regression analysis. Conclusions: These findings indicate that ST correlate with serum leptin levels and that leptin resistance may be involved in the pathogenesis of ST in susceptible individuals.Öğe Suction bullae as a complication of prolonged cupping(Wiley, 2006) Tuncez, F.; Bagcı, Y.; Kurtipek, G. S.; Erkek, E.…Öğe Unexpected clinical involvement of hereditary total leuconychia with congenital fibrosis of the extraocular muscles in three generations(Wiley-Blackwell, 2009) Karadeniz, N.; Erkek, E.; Taner, P.We report familial segregation of hereditary total leuconychia (HTL) with ptosis and restriction of ocular motility due to congenital fibrosis of the extraocular muscles type 1 (CFEOM1) in three generations. In this family, 4 people have HTL and ptosis, and there is restriction of ocular motility due to CFEOM1 in 10 members of the family. To our knowledge, this is the first description of familial segregation of CFEOM1 and HTL, and the second report of unexpected clinical involvement of CFEOM1. We suggest that CFEOM1 is not an isolated phenomenon in these cases. These phenotypes provide valuable insight into the function of the gene(s) localized to 12q13, giving a new perspective on the clinical component of molecular dysmorphology, but this requires further clarification.Öğe Unilateral lesions in a patient with keratosis follicularis(European Acad Dermatology & Venereology, 2001) Erkek, E.; Atasoy, P.…Öğe Vasculopathic skin lesions following epilation, leading to a discovery of hepatitis C virus infection(Wiley, 2007) Erkek, E.; Ayaşlıoğlu, E.; Erdoğan, S.; Bagci, Y.…Öğe Wood's light excites white fluorescence of type I hereditary punctate keratoderma(Blackwell Publishing, 2007) Erkek, E.; Ayva, S.…
