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  • Küçük Resim
    Öğe
    Contribution of amniotic membrane to the healing of iatrogenic vas deferens injury
    (Tubitak Scientific & Technological Research Council Turkey, 2021) Demir, Sabri; Ertürk, Ahmet; Zengin, Mehmet; Yıldız, Dinçer; Karahan, Siyami; Senel, Emrah
    Background/aim: Iatrogenic vas deferens injury is one of the most serious complications of operations in the inguinal region. Vasovasostomy is performed as treatment. However, stenosis is common after vasovasostomy. Oligospermia or azoospermia may develop and result in infertility. This study aimed to investigate the effect of amniotic membrane on healing in vas deferens injuries. Materials and methods: Four groups consisting of 10 rats each were formed. No procedure was performed in Group-I. In Group -II, the left vas deferens was transected and left to spontaneous healing. In Group-III, the left vas deferens was transected, and end -to-end anastomosis was performed. In Group-IV, the left vas deferens was transected, end-to-end anastomosis was performed, and it was closed with a wrapping of amniotic membrane on the anastomosis line. Rats were sacrificed after 60 days, and each left vas deferens was evaluated. Lumen patency was checked by passing methylene blue through the vas deferens. Subsequently, the vas deferens was evaluated both macroscopically and histopathologically. Data were evaluated using SPSS version 21.0. p < 0.05 was considered statistically significant for all variables. Results: The anastomosis lines in Group-IV healed better than those in Group-III, and less stenosis was observed. There were differences between the groups in terms of luminal patency (p = 0.009), adhesions to surrounding tissues (p = 0.02) and separation of the ends of the vas deferens (p = 0.03). Conclusion: We observed improvement on luminal patency and histology of rat vas deferens injury after surrounding human amniotic membrane on the transected and repaired surface. Further studies are needed to apply this promising result on human beings.
  • Küçük Resim
    Öğe
    Laparotomi yapılan hastalarda brid ileus risk faktörleri ve tedavi yaklaşımlarının değerlendirilmesi
    (2017) Ertürk, Ahmet; Karaman, İbrahim; Karaman, Ayşe; Yılmaz, Engin; Afşarlar, Çağatay Evrim; Erdoğan, Derya; Çavuşoğlu, Yusuf Hakan
    Amaç: Postoperatif yapışıklıklar intestinal obstrüksüyona yol açması, reoperasyon durumlarında abdominal eksplorasyonu zorlaştırması, organ yaralanmalarına sebep olması nedeniyle hem hasta hem de hekimler için önemli bir klinik durumdur. Bu çalışmada brid ileus gelişimine etki eden faktörlerin saptanması ve brid ileusdaki tedavi sonuçlarının değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: 2005-2010 yılları arasında çeşitli nedenlerle laparotomi yapılan hastalar brid ileus gelişimi açısından retrospektif olarak değerlendirildi. Bulgular: Bu çalışmaya laparotomi yapılan 3271 hasta dahil edildi. Apandisit en sık laparotomi endikasyonuydu (%66). 152 hastada (%4,6) postoperatif brid ileus geliştiği tespit edildi. Bunların %88'inin postoperatif ilk 6 ayda, %99'unun da ilk 3 yıl içinde geliştiği görüldü. Yaş ve cinsiyet ile brid ileus gelişimi arasında ilişki yoktu. Vakaların %23'ü kirli vasıfta ameliyatlardı. Temiz, temiz kontamine ameliyatlardan sonra brid ileus gelişme oranı %3,4 iken, kontamine ve kirli ameliyatlardan sonra bu oran %10,9 olarak bulundu. Batın içerisine dren yerleştirilmesinin brid ileus gelişimini etkilemediği saptandı. Ameliyat süresi uzadıkça postoperatif brid ileus gelişme oranının arttığı tespit edildi. Ayrıca ameliyatta Meckel divertikülü gibi ek patolojiler araştırılan hastalarda brid ileus gelişme oranının 3 kat arttırdığı görüldü.Brid ileus gelişen hastaların %61'i nonoperatif-konservatif yollarla tedavi edilirken %39'unda cerrahi girişim gerektiği tespit edildi. Sonuçlar: Çalışmamızda batın içinde uygulanan ek girişimlerin, operasyon süresinin uzun olmasının ve intraperitoneal kontaminasyonun brid ileus gelişimini artırdığı gösterilmiştir. Bu konulara dikkat edilmesinin brid ileus gelişimini azaltabileceği düşünülmüştür. Çocuk yaş grubunda uygun vakalarda konservatif tedavi ile daha yüksek oranlarda başarı sağlanabileceği kanısına varılmıştır
  • Küçük Resim
    Öğe
    The impact of bone marrow-derived mesenchymal stem cells on experimental testicular torsion in rats
    (Tubitak Scientific & Technological Research Council Turkey, 2022) Ertürk, Ahmet; Demir, Sabri; Günal, Yasemin Dere; Zengin, Mehmet; Çınar, Miyase; Yıldız, Dinçer; Karahan, Siyami
    Background/aim: The aim of this study was to investigate the healing effects of bone marrow-derived mesenchymal stem cells (BM-MSCs) on experimental testicular torsion in rats. Materials and methods: Three groups consisting of 10 Wistar albino rats were created. In Group I, the left testicle was explored and relocated in the scrotum without any attempt to modify it. In Group II, the left testicle underwent torsion for three h and then was detorsed and relocated. In Group III, in addition to torsion and detorsion, BM-MSCs were administered intratesticularly. The rats were sacrificed on the seventh day, and the healing status of the testicles was investigated with histopathological and biochemical analyses. BM-MSC involvement was investigated by immunofluorescence microscopy. Statistical analysis was performed using SPSS 15.0. A p-value < 0.05 was considered statistically significant for all variables. Results: Immunofluorescence microscopy showed that BM-MSCs were located around the Leydig cells in Group III. Under light microscopy, the mean Johnsen Score of Group III was significantly higher than that of Group II (p = 0.035). The interleukin-10 (IL-10) level was significantly higher in Group III compared to Group II (p = 0.003). While the malondialdehyde (MDA) values in Group I (the control group) were lower than in the other groups (p = 0.037), the superoxide dismutase (SOD) values were similar (p = 0.158). Although there was no statistically significant difference between Group II and Group III in terms of MDA, it was lower in Group III. Although the tissue SOD levels were higher in Group III than in Group II, the difference was not statistically significant. Conclusion: This study has demonstrated that BM-MSCs significantly corrected the Johnsen Score and increased anti-inflammatory cytokine levels after testicular torsion. BM-MSCs can be used in testicular torsion as supportive therapy to minimize tissue damage.