Yazar "Eryol, Merve" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • [ X ]
    Öğe
    Comparison of Gleason scoring and the new grade-group system in prostate cancers: a 15-year retrospective study
    (2020) Zengin, Mehmet; Eryol, Merve; Akkaya, Merva Aydemir; Balcı, Mahi; Yalçın, Selim; Tuğlu, Devrim
    Aim: Prostate cancer is the most common malignant tumour in men. The most widely used histological grading scheme for prostate cancer is Gleason scoring. After the original, this system has been modified several times. In this study, we retrospectively investigated the new Grade-group system (GGS). Material and Method: This study includes 486 cases diagnosed with prostate cancer between 2000 and 2015. All cases were re-grouped for the new Grade-group system and its relationship with prognosis was examined. Results: Grade-group system subgroups had a statistically significant relationship between prognostic factors and this relationship was more significant between GGS 2 and GGS 3 [tumor status (p<0.001), age (p=0.045), PN invasion (p<0.001), stage (p=0.004), and LN status (p<0.001)]. In univariable survival analysis, there was a significant difference between Grade-group system subgroups (for GGS 2-GGS 3, RFS: p=0.035 and OS: p=0.012; for GGS 4-GGS 5, RFS: p=0.001 and OS: p=0.001). In multivariable survival analysis, GGS subgroups were found to be an independent survival parameter for prostate cancer (for GGS 2-GGS 3, OS: HR=2.56, p=0.012 and RFS: HR=2.69, p=0.038; for GGS 4-GGS 5, OS: HR=2.84, p=0.011 and RFS: HR=2.59, p<0.001). Conclusions: According to our results, the new Grade-group system performs the prognostic risk grading more accurately than the old classification. Also, the fact that this system contains fewer categories and is simpler has increased the interobserver compatibility.
  • [ X ]
    Öğe
    İNSİDENTAL SAPTANAN MEZENTERİK KALSİFİYE FİBRÖZ TÜMÖR: OLGU SUNUMU
    (2021) Balcı, Mahi; Eryol, Merve
    Kalsifiye fibröz tümör, nadir görülen iğsi hücreli bir tümördür. Genelikle insidental olarak saptanır, fakat semptomatik olduğunda tutulum bölgesine göre klinik prezentasyon farklılık gösterir. İntra abdominal bölge, yumuşak doku ve plevra predileksiyonu gösterir. Sıklıkla çocuk ve genç erişkinlerde izlenir. Hücreden fakir fibrokollagenöz stroma zemini, lenfoplazmositik agregatlar ve lenfoid foliküller, distrofik ve/veya psammomatöz kalsifikasyon içeren spesifik histopatolojik özelliklere sahiptir. Az sayıdaki iğsi hücrelerde vimentin ve faktör XIIIa pozitivitesi saptanır. Biz burada insidental olarak saptanan mezenterik kalsifiye fibröz tümör vakasını benign ve malign lezyonlarla klinikopatolojik olarak karışabilmesi, nadir görüldüğü için akla gelmesi zor bir antite olması sebebiyle, literatür bilgisi eşliğinde sunmayı amaçladık.
  • Küçük Resim
    Öğe
    Rare Plasmacytoid Urothelial Carcinoma of the Bladder: Two Case Reports
    (Urol & Nephrol Res Ctr-Unrc, 2019) Devrim, Tuba; Atac, Fatih; Altunkaya, Canan; Ozbek, Aye; Ozdemir, Gulhan; Eryol, Merve
    Plasmacytoid urothelial carcinoma is a rare and aggressive form of urothelial carcinoma characterized with delayed presentation and poor prognosis. Very few cases of this carcinoma have been reported in the literature. Here, we report and discuss two cases of bladder plasmacytoid urothelial carcinoma of a 57-year-old male presented with renal colic, and a 33-year-old female presented with macroscopic hematuria. Pathologic examinations of the transurethral biopsies revealed urothelial carcinoma with plasmacytoid appearance. Subsequently, immunohistochemical evaluation showed positive expression of epithelial markers and CD138. Additionally, losing of the membranous expression of E-cadherin verified the diagnosis of plasmacytoid urothelial carcinoma.