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Öğe Effects Of Acetamiprid, Methomyl, And Deltamethrin On Steroidogenesis In Cultured Bovine Luteal Cells(Parlar Scientific Publications (P S P), 2017) Arikan, Sevket; Simsek, Ozkan; Kalender, Hakan; Essiz, Dinc; Atmaca, Nurgul; Kabakci, Ruhi; Bilmen, Fatih SultanAcetamiprid, methomyl, and deltamethrinare widely used insecticides in agriculture and industry; thus, livestock may receive substantial exposure to such substances. This study was designed to evaluate the effect of these agents on bovine luteal cell steroidogenesis.Cells were incubated with acetamiprid (0.1 mM, 1 mM, or 10 mM), methomyl (0.1 mM, 1 mM, or 10 mM), or deltamethrin (0.01 mM, 0.1 mM, or 1 mM) for 5 days. Incubation with 1 mMacetamiprid resulted in significantly reducedpro-gesterone production by day 5. Incubation with 1 mM methomyl had no effect on progesterone pro-ductionby day 3 but did result in significant inhibi-tionby day 5. Incubation in 0.1 mM and 1 mMdelta-methrin resulted in significant reduction on both days 3 and 5. All three insecticides diminish luteal progesterone synthesis, with rank order methomylÖğe The effects of experimental aflatoxicosis on the exocrine pancreas in quails (Coturnix coturnix japonica)(Springer Heidelberg, 2007) Şimşek, Nejdet; Ergun, Levent; Ergun, Emel; Alabay, Belma; Essiz, DincThe present investigation was undertaken to assess the effects of aflatoxin (AF) on the exocrine pancreas in quails by means of light and electron microscopy. A total of 30 quails were divided into three groups, each composed of ten animals. Total AF was incorporated into the diet of these groups, at doses of 0, 2.5, and 5.0 mg of AF/kg feed, ppm, respectively. The quails were raised in cages with electrical heating and 24-h lighting for a period of 3 weeks. Ad libitum access was provided to feed and drinking water. Pancreas samples were taken for light and electron microscopic examination from animals that were killed by means of cervical dislocation at the end of the study. Light microscopic examination demonstrated mild mononuclear cell infiltration of exocrine tissue and vacuolisation of acinar cells in the group fed on AF at 2.5 ppm. On the other hand, electron microscopic examination demonstrated degranulation of the rough endoplasmic reticulum (rER) of acinar cells, decrease in the number of zymogen granules and free ribosomes and polisomes, and dilatation of capillaries in the group fed on AF at a dose of 2.5 ppm. Numerous degenerative acinar cells were determined in the group fed a diet containing 5.0 ppm AF, in addition to the findings common with the other group exposed to the toxin.Öğe Effects of mancozeb, metalaxyl and tebuconazole on steroid production by bovine luteal cells in vitro(Elsevier Science Bv, 2018) Atmaca, Nurgul; Arikan, Sevket; Essiz, Dinc; Kalender, Hakan; Simsek, Ozkan; Bilmen, Fatih Sultan; Kabakci, RuhiMancozeb, metalaxyl and tebucanazole are widely used pesticides in agriculture and industry to treat plant pathogenic fungi. Livestock may be exposed to such substances by consuming contaminated plants. The present study was designed to evaluate the effects of these three fungicides on bovine luteal cell steroidogenesis. Luteal slices from mid-cycle corpus luteum were dissociated into single cell suspension in aerated (02) culture media (DMEM/F12) by enzymatic digestion. The cells were incubated in newborn calf serum (10%) for 18 h and then with serum-free media containing mancozeb (0.01 mu M, 0.1 mu M, 1 mu M), tebuconazole (1 mu M, 10 mu M, 100 mu M) or metalaxyl (100 mu M, 500 mu M, 2500 mu M) for additional 96 h. The medium was replaced on day 1 and 3; and the retrieved medium was stored at - 20 degrees C until progesterone assay. Treatment of cells with three different fungicides induced dose dependent variable decrease in steroid synthesis during incubation periods. Incubation of cells with 1 pM mancozeb exhibited a 33% decline in steroid synthesis on day 3 and 48% decline on day 5 compared with controls. Treatment of cells with 100 M tebuconazole and 500 mu M metalaxyl resulted in a 65% and 31% decrease, respectively, in progesterone accumulation on day 5 of incubation. Fungicide induced suppressive effects on luteal steroidogenesis were as metalaxyl < tebuconazole < mancozeb. Results of the present study suggest that designated concentrations of all three fungicides studied might have varying degrees of adverse effects on luteal steroidogenesis.Öğe Effects Of Moldstop® On Aflatoxicosis In Quails(Natl Veterinary Research Inst, 2008) Cengiz, Oezcan; Cakir, Serkan; Sehu, Adnan; Essiz, Dinc; Erguen, Emel; Erguen, Levent; Altintas, LeventThis study was conducted to evaluate the toxic effects of anatoxin (AF) oil the growth performance of quails, and to determine the preventive efficacy of MOLDSTOP (R) (calcium formate, calcium propionate, citric acid, sorbic acid, acetic acid, and carrier). A total of 60 one-clay-old quails (Coturnix coturnix japonica) of both sexes were equally divided into four experimental groups each comprising of five replicates of three birds. The supplementation of diet with AF decreased significantly (P<0.001) the feed consumption. The 0.5% addition of MOLDSTOP (R) to the AF diet did not significantly prevent or reduce negative effect of AF on feed consumption at any time period. Light microscopic examination demonstrated that the addition of MOLDSTOP (R) did not decrease flat deposition Caused by the toxin, and besides, an electron microscopic examination indicated the reorganisation in the endoplasmic reticulum and increase in the number of ribosomes and polisomes compared to the AF plus MOLDSTOP (R) group. The data indicated that the addition of MOLDSTOP (R) to diets containing AF did not prevent the negative effects of AF observed in the quail.Öğe Effects of selected fungicides on steroid synthesis by bovine luteal cells(Wiley-Blackwell, 2016) Atmaca, Nurgul; Arikan, Sevket; Essiz, Dinc; Kalender, Hakan; Simsek, Ozkan; Bilmen, Fatih Sultan; Kabakci, Ruhi…Öğe In vitro Effects of Linuron on Luteal Progesterone Synthesis(Wiley-Blackwell, 2016) Bilmen, Fatih Sultan; Arikan, Sevket; Simsek, Ozkan; Atmaca, Nurgul; Kalender, Hakan; Essiz, Dinc; Kabakci, Ruhi…Öğe Protective effects of silymarin on fumonisin B-1-induced hepatotoxicity in mice(Korean Soc Veterinary Science, 2014) Sozmen, Mahmut; Devrim, Alparslan Kadir; Tunca, Recai; Bayezit, Murat; Dag, Serpil; Essiz, DincThe present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B-1 (FB1) in BALB/c mice. The mice were divided into six groups (n = 15). Group 1 served as the control. Group 2 was the silymarin control (100 mg/kg by gavage). Groups 3 and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1, intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5 received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), and Group 6 was given a higher dose of FB1 (4.5 mg/kg FB1) with silymarin (100 mg/kg). Silymarin treatment significantly decreased (p < 0.0001) the apoptotic rate. FB1 administration significantly increased (p < 0.0001) proliferating cell nuclear antigen and Ki-67 expression. Furthermore, FB1 elevated the levels of caspase-8 and tumor necrosis factor-alpha mediators while silymarin significantly reduced (p < 0.0001) the expression of these factors. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expressions were significantly elevated in Group 4 (p < 0.0001). Silymarin administration alleviated increased VEGF and FGF-2 expression levels (p < 0.0001). In conclusion, silymarin ameliorated toxic liver damage caused by FB1 in BALB/c mice.
