Yazar "Günaydin, Serdar" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Clinical and laboratory evaluation of anti-microbial efficacy of photocatalysts
    (2011) Özpolat, Berkant; Çavuşo?lu, Tarik; Yilmaz, Seyhan; Büyükkoçak, Ünase; Günaydin, Serdar
    Aim This study aims at investigating and testing the tentative antimicrobial efficacy; in vitro and in- hospital applications of apatite coated ferrum titanate which is one of the new generation photocatalysts. Material and Methods 30 sterile petri dishes were kept under florescent light for 4 days following the application of 20 ppm apatite coated ferrum titanate aerosol. 0.5 McFarland (1.5X108 CFU/mL -CFU=colony forming unit) Pseudomonas aeruginosa and 0.5 McFarland Acinetobacter baumannii were cultured on 10 separate dishes. 10 unprocessed dishes were used as controls. Samples were evaluated for bacterial survival rate (CFUX100/CFU) after application. In the second step, same photocatalyst aerosol was applied as 0.012 L/m2 with the specific kit on the surfaces of different units within the hospital. Particle count was measured and compared before and one-month after the photocatalyst application by lumimeter. Results Bacterial survival rate was significantly lower on photocatalyst applied surfaces versus control for Pseudomonas aeruginosa after second day of application (p<0.001) (60±8% / 95±9%). This difference continued up to the 4th day gradually (3. day: 35±5% / 90±9%; 4. day:22±5% / 85±8%). Bacterial survival rate was significantly lower on photocatalyst applied surfaces versus control for Acinetobacter baumannii after the second day of application (55±7% / 87±8%) (p<0.01). This difference continued up to the 4th day gradually (3. day:40±5% / 80±8%; 4. day:15±5% / 78±7%). Particle count on photocatalyst applied surfaces diminished 97.15% in operating room, 95.61% in ICU, 98.30 in physicians' room, 94.13% in wards and 97.04% in hospital kitchen. Conclusions As a result of our pioneering study on the evaluation of photocatalyst, we think that it may be one of the economic and safe alternative methods of hospital sterilization based on bactericidal and bacteriostatic efficacy confirmed in both laboratory and clinical applications.
  • Küçük Resim
    Öğe
    Comparison of polymethoxyethylacrylate-coated circuits with leukocyte filtration and reduced heparinization protocol on heparin-bonded circuits in different risk cohorts
    (Sage Publications Ltd, 2006) Günaydin, Serdar; McCusker, Kevin; Vijay, Venkataramana; İşbir, Selim; Sari, Tamer; Onur, Mehmet Ali; Zorlutuna, Yaman
    Objectives: The relative benefits of strategic leukofiltration on polymer-coated and low-dose heparin protocol on heparin-coated circuits were studied across EuroSCORE patient risk strata for three different cohorts. Methods: In a prospective, randomized study, 270 patients undergoing coronary artery bypass grafting were allocated into three groups (n = 90): Group 1 - polymethoxyethylacrylate-coated circuits + leukocyte filters; Group 2 - polypeptide-based heparin-bonded circuits with reduced heparinization; and Group 3 - Control: uncoated circuits. Each group was further divided into three subgroups (n = 30), with respect to low- (EuroSCORE 0-2), medium- (3-5), and high- (6+) risk patients. Blood samples were collected at T1: following induction of anesthesia; T2: following heparin administration; T3: 15 min after CPB; T4: before cessation of CPB; T5: 15 min after protamine reversal; and T6: ICU. Results: In high-risk cohorts, leukocyte counts demonstrated significant differences at T4 and T5 in Group 1, and at T4 in Group 2. Platelet counts were preserved significantly better at T4 and T5 in both groups (p < 0.05 versus control). Serum IL-2 and C3a levels were significantly lower at T3, T4 and T5 in Group 1, and T4 and T5 in Group 2 (p < 0.05). Postoperative bleeding, respiratory support time and incidence of atrial fibrillation were lower in the study groups versus control. Cell counts on filter mesh and heparin-coated fibers/ circuits were significantly higher in the high-risk cohorts versus uncoated fibers. Phagocytic capacity increased on filter mesh, especially in high-risk specimens. SEM evaluation demonstrated better preserved coated circuits. Conclusion: Leukofiltration and coating reduced platelet adhesion, protein adsorption, atrial fibrillation and reduced heparinization acted via modulation of systemic inflammatory response in high-risk groups.