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    Adenosine deaminase and 5 '-nucleotidase activities in saliva from patients with oral and laryngeal cancer
    (Wiley, 2005) Saracoğlu, Umut; Güven, Orhan; Durak, İlker
    Objective: The aim of this study was to evaluate saliva's activities of adenosine deaminase (ADA) and 5'-nucleotidase (5'-NT) enzymes and their utility as diagnostic and therapeutic markers in oral and laryngeal cancer. Materials and Methods: Pre- and post-operative saliva's activities of ADA and 5'-NT enzymes were measured in patients with squamous cell oral (n=10) and laryngeal cancer (n=17) and compared with control saliva samples (n=19). Results: The ADA was found to be lower in saliva of the patients with oral cancer compared with the laryngeal cancer and controls. However, no significant differences were found between pre- and post-operative values for both enzymes in the patient groups. We also could not find statistically significant differences between saliva's activities of 5'-NT in patients and control subjects. Conclusions: Low activity of ADA observed in saliva of the patients with oral cancer has been suggested as a compensatory mechanism against rapid purine and DNA metabolism in cancer cells. The current study does not support the hypothesis that saliva's activities of these enzymes may be used as additional diagnostic and prognostic cancer markers.
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    Changes in pharyngeal airway space and hyoid bone positions after body ostectomies and sagittal split ramus osteotomies
    (Lippincott Williams & Wilkins, 2005) Güven, Orhan; Saraçoğlu, Umut
    Although mandibular setback might lead to possible pharyngeal narrowing, the development of obstructive sleep-related breathing disorders may occur because of multiple factors. In this study, the changes in the pharyngeal airway space (PAS) and the hyoid bone position have been evaluated before and after surgery in patients who underwent body ostectomy (BO) and sagittal split ramus osteotomy (SSRO). In addition, the effects of the BO on PAS and on hyoid bone position have been compared with the effects of the SSRO. Material and Methods: Thirty patients with mandibular prognathism underwent mandibular setback osteotomy. The patients were divided into two groups: BO group, 15 patients (5 men, 10 women) who underwent BO; and SSRO group, 15 patients (11 men, 4 women) who underwent SSRO. Changes in PAS and hyoid bone position were analyzed throughout the preoperative and early and long-term postoperative periods via lateral cephalometric radiographs. Results: A decrease has been observed in the PAS area and the anteroposterior dimension of the PAS detected in all patients in the long-term period. Hyoid bone revealed backward and downward movement during the early postoperative period; however, it showed a tendency to return to its original anatomic position during the long-term postoperative period. None of the patients had disturbances in respiration. Conclusion: After BO and SSRO, a decrease in PAS area was observed, and this decrease also continued in the long-term period. Our results revealed a decrease in PAS area after BO, but the decrease was less than that in cases having SSRO.
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    Healing of bone defects by an osteopromotion technique using solvent-dehydrated cortical bone plate: A clinical and radiological study
    (Lippincott Williams & Wilkins, 2006) Güven, Orhan; Tekin, Umut Saraçoğlu
    Osseous defects of the jaws following trauma, cysts, infection or congenital deformity may show poor osteogenesis and the affected area may never be completely filled with bone. It is widely accepted in guided tissue regeneration that physically halting soft connective tissue proliferation into bone allows bone regeneration. This concept is called the "osteopromotion principle." The purpose of the present study was to evaluate the effect of solvent-dehydrated cortical bone plates as a barrier to allow bone regeneration by assessing the osteopromotion principle. 30 patients (18 male, 12 female) with cystic lesions of the jaws were assigned to two different groups. The patients in Group A were treated by enucleation. In Group B, were treated by removal of the lesion and placing a solvent-dehydrated cortical bone plate on top of the cyst cavity to avoid ingrowth of connective tissue. Both groups were evaluated radiographically using spiral-computed tomography (CT) before surgery and 12 months postoperatively. In group B, all cystic cavities showed complete bone healing in 12 months. At the same period, invasion of the soft connective tissue were observed in the patients treated only by enuclation. This study demonstrates that solvent-dehydrated cortical bone plates can be used as a barrier in treatment of cyst cavities and they hinder ingrowth of connective tissues and promote successful bone healing.
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    Surgical and Prosthodontic Rehabilitation in a Patient With Freeman-Sheldon Syndrome
    (Lippincott Williams & Wilkins, 2010) Güven, Orhan; Tekin, Umut; Hatipoğlu, Murat
    Dental and prosthetic rehabilitation possess significant challenges in patients who have Freeman-Sheldon syndrome. Microsomia is one of the main diagnostic criteria for Freeman-Sheldon syndrome, and it creates difficulty in working in the intraoral cavity. Most patients with small orifice often have difficulties in oral hygiene maintenance, and it gives rise to loss of some of the teeth. It incurs the need for dental and oral treatment. In the presented study, the patient with limited mouth opening that disabled the dentists to perform dental treatment was given prosthodontic therapy after having commissuroplasty and implant placement simultaneously.