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    Comparison of Attachment Styles of Individuals with Opioid Use Disorder and Individuals with Obesity
    (Turkiye Sinir Ve Ruh Sagligi Dernegi, 2023) Acidere, Ahmet Bugra; Asan, Omer; Yalcin Sahiner, Safak; Sahiner, Ismail Volkan; Goka, Erol
    Objective: The aim of this study is to identify the attachment style displayed by obese individuals and to compare it with the attachment style of individuals diagnosed with opioid use disorder (OUD) and a healthy control group. Method: A total of 201 participants were included in the study, consisting of 66 individuals diagnosed with obesity, 62 diagnosed with OUD and 73 healthy controls. Sociodemographic Data Form and Adult Attachment Style Scale were administered to all participants, the Addiction Profile Index (API) was administered to participants diagnosed with OUD and the Yale Food Addiction Scale was administered to those diagnosed with obesity. Results: The results of the study revealed that the attachment styles of individuals diagnosed with obesity showed a similar distribution to those diagnosed with OUD, and the distribution of attachment styles in both groups was found to be different from that of the healthy control group. The mean scores for ambivalent/anxious attachment style and secure attachment style were found to be similar for the obesity group and the OUD group, while the OUD group had significantly higher avoidant attachment score. The avoidant attachment style score of OUD group increase as the severity of dependency increases. Additionally, 42.4% of the group was found to be food addicted, and in this group, the mean scores for ambivalent/ anxious attachment style were found to be significantly higher. Conclusion: In the study, significant similarities were obtained in terms of attachment styles among participants diagnosed with obesity and OUD. The differentiation of these similarities from the control group has increased the strength of the study.
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    Evaluation of galectin-1 and galectin-3 levels in patients with bipolar disorder: is galectin-3 associated with treatment response?
    (Assoc Brasileira Psiquiatria, 2024) Aytekin, Meryem Yuksel; Kahve, Aybeniz Civan; Ekinci, Rabia Nazik; Nural, Arzu Sakalli; Cakmak, Isik Batuhan; Nayci, Nagihan Ayaz; Goka, Erol
    Objective: Galectins (Gal), which have been linked with inflammatory response in the central nervous system, may play an important role in the pathogenesis of bipolar disorder. In this study, we investigated whether serum Gal-1 and Gal-3 levels are related to bipolar disorder. Methods: Thirty-six patients diagnosed with bipolar disorder were included. C-reactive protein, Gal-1, Gal-3 serum concentrations were evaluated on the first day of hospitalization and the third week of treatment and were compared with 41 healthy controls. Illness severity was evaluated with the Young Results: Upon hospitalization, the C-reactive protein levels of bipolar disorder patients were significantly higher than in the third week of treatment or in healthy controls. Gal-1 levels on the first day of hospitalization and the third week of treatment were higher than those of healthy controls.There was no significant difference between patient Gal-3 levels upon hospitalization and those of healthy controls; at the end of the third week of treatment, Gal-3 levels were significantly higher than on the first day of hospitalization. Conclusion: Our study is the first to show a change in Gal levels after treatment and to evaluate the role of Gal in bipolar disorder. Gal-1 may play a role in the pathophysiology of bipolar disorder. Gal-3 could be a biomarker candidate for assessing treatment response.