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Öğe Common surgical pitfalls in the skull(Elsevier Science Inc, 2003) Keskil, S..; Gozil, R.; Calguner, E.BACKGROUND A detailed knowledge of the morphologic variations in the ossicles, foramina, and ridges of the skull vault and skull base is vital to performing safe radical surgery. METHODS A surgical reminder of possible pitfalls was composed based on the incidences of most of the minor variations such as the supraorbital notch, frontal foramen, metopism, foramen caecum, parietal foramina, bony defects in the fossa occipitalis cerebellaris, Inca bone, foramen lacerum anterius, incomplete posterolateral wall of the foramen ovale, absence of the medial or posterior wall of the foramen spinosum, foramen innominatus, foramen meningoorbitale, bony dehiscence of the internal carotid canal, bony ridge or torus in the floor of the external auditory meatus, foramen of Huschke, precondylar tubercle, foramen hypoglossi, anterior condylar canal, hypoglossal bridging, divided articular surface of the occipital condyle, high jugular bulb, paramastoid process, atlantooccipital assimilation, ossicle of Kerkring, delta or keyhole shaped bony defects in the anterior border of foramen magnum, foramen of Vesalius, posterior condylar canal, mastoid emissary foramen and occipital foramen in 200 skulls. CONCLUSION Recognition of these structures and their possible variations will help in distinguishing normal from potentially abnormal structures during computed tomography and magnetic resonance imaging examinations, and in avoiding misinterpretations that lead to confusion during surgical interventions. Instrumentation near potential bone gaps may traumatize important neural or vascular structures. (C) 2003 Elsevier Science Inc.Öğe Effects of vasoconstriction on the acute anterior pituitary hormonal response to head injury(Churchill Livingstone, 2002) Keskil, Z.; Evrenkaya, T.; Gozil, R.; Calguner, E.; Keskil, S.Since cerebral vasoconstriction alone may impair the hypothalamic and pituitary circulation, we planned to investigate whether the hormonal response to the vasoconstriction that may be induced by the head injury is a significant component of the general acute hormonal response to head injury. Although diffuse adrenocorticotropic hormone immunohistochemical staining of the adenohypophysis of rabbits was observed in the head trauma administered group, only mild positive staining was present in the Endothelin-1 administered group. However, decreased prolactin staining was found in both of the groups. It is postulated that trauma induced vasoconstriction may not be an important manipulating factor in the corticotrophic hormone response to injury, while it may be responsible for the decreased prolactin response. (C) 2002 Elsevier Science Ltd. All rights reserved.Öğe The immunohistochemical approach to determine the origin and possible function of the juxtaoral organ in dogs(Saudi Med J, 2005) Bahçelioğlu, M.; Çalgüner, E.; Erdoğan, D.; Elmas, C.; Gozil, R.; Keşkil, S.; Kadıoğlu, D.Objective: In this study, we applied immunohistochemical techniques on the functionally little known organ of Chievitz (juxtaoral organ [JOO]) in dogs to determine its origin and possible function. Methods: The term abortive materials of 6 Doberman dogs were used for experimental procedures in July 2002 to June 2003 at Gazi University Faculty of Medicine, Ankara, Turkey, after routine light microscopic tissue preparation, the sections were stained with Masson's trichrome stain. In order to elucidate the function -related origin of the organ, we used epidermal growth factor (EGF-r), transforming growth factor (TGF-alpha) and nerve growth factor (NGF-beta) immunohistochemical stains. Results: We observed a very strong and 'widespread immunoreactivity of EGF-r and TGF-a on simple squamous capsular cells. We detected nerve growth factor-beta positivity in granular form both in simple squamous capsular cells and in neighboring connective tissue. However, we did not detect EGF-r reactivity on parenchymal cells except a weak immunoreactivity on central ones. We noticed transforming growth factor-a in most of the parenchymal cells while we observed NGF-beta strongly in all the parenchymal cells. Conclusion: These results may point out that the JOO may be of mesothelial or epithelial origin. Having NGF-alpha. positive granules and close relationship with blood vessels may imply a neurosecretory function. We believe that our study may add new perspectives to the function of the JOO.