Yazar "Guzoglu, Nilufer" seçeneğine göre listele

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    A key challenge in gestational diabetes screening: resistance to oral glucose tolerance test screening and implications for neonatal health
    (2021) Tursun, Serkan; Yeral, Mahmut İlkin; Yıldız, Volkan; Ünal, Elif Gökçe; Guzoglu, Nilufer; Aliefendioglu, Didem
    Objective: Gestational diabetes mellitus (GDM) is the most common endocrine disorder in pregnancy, and the number of pregnant women resistant to oral glucose tolerance test (OGTT) has increased significantly in recent years. In this study, we investigated the extent of resistance to OGTT screening among pregnant women followed-up in our hospital and the effects of this situation on the newborn. Materials and Method: We conducted this study with pregnant women and their babies who were regularly followed up in the Obstetrics and Gynecology Department and Pediatrics Department of our hospital between December 1, 2015, and December 31, 2017. While we included those who did not accept an OGTT in the study group (Group 1), and we created the control group with those who accepted the test. Besides, the control group was divided into two groups as those accepted as GDM (Group 2) and normal (Group 3). Ultimately, we scrutinized the relationship between the OGTT and clinicopathological findings. Results: We included a total of 906 pregnant women and their babies in the study. Of women, 374 (41.3%) did not accept the test. The cesarean (C/S) delivery rate was significantly lower in the babies of mothers who did not have an OGTT (p<0.05). In addition, the hospitalization rate of the newborn babies of mothers who had an OGTT but did not have gestational diabetes was significantly lower than the other two groups (p<0.05). Conclusion: Our study revealed that resistance to the OGTT was a far-reaching issue and may lead to an increase in the hospitalization of newborns. Our results suggested that the inability to perform OGTT may have been due to some unidentified problems.
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    Congenital Microvillus Inclusion Disease in the Differential Diagnosis of Intractable Metabolic Acidosis
    (Elsevier Taiwan, 2017) Guzoglu, Nilufer; Aliefendioglu, Didem; Gulerman, Fulya; Gucer, Safak; Kaymaz, Figen
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    Evaluation of Patients with Neonatal Thrombosis
    (Springer India, 2023) Guzoglu, Nilufer; Albayrak, Meryem; Aliefendioglu, Didem
    The aim of the study is to characterize acquired and genetic risk factors and to give an account of the hereditary thrombophilia panel in neonatal thrombosis. All newborns diagnosed with neonatal thrombosis in a level III NICU were included in this retrospective cohort study. A total of 1850 patients were admitted to the NICU during the 5-y period; and 11 patients were diagnosed with thrombosis (0.58%). The most common risk factors were central venous catheter placement, hypoxia and prematurity and related complications, and sepsis. Four patients were investigated regarding the inherited risk factors for thrombosis. In these 4 patients, homozygous A1298C alleles of MTHFR and heterozygous FXIIIV34L mutations; homozygous PAI-SERPINE1 and heterozygous MTHFRA1298C mutations; compound heterozygous mutations of MTHFRC677T and MTHFRA1298C; and compound heterozygous mutations of MTHFRC677T, MTHFRA1298C, and PAISERPINE1 were detected respectively. In conclusion, neonatal thrombosis is multifactorial; newborns with acquired risk factors may also have hereditary risk factors.Trial InformationClinicalTrials.govIdentifier: NCT05367466
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    Haemorrhagic pneumonia caused by Stenotrophomonas maltophilia in two newborns
    (J Infection Developing Countries, 2015) Guzoglu, Nilufer; Demirkol, Fatma N.; Aliefendioglu, Didem
    Invasive procedures and antibiotic treatment increase the risk of nosocomial infections in neonatal intensive care units. Early identification and appropriate treatment is important. Herein we report two cases of massive hemorrhagic pneumonia caused by Stenotrophomonas maltophilia. The first case was diagnosed with congenital pneumonia; a chest tube was inserted because of pneumothorax on the third day of life. The second case had been referred with respiratory distress syndrome, and bilateral pneumothorax was present on admission. Upon follow up, the cases' clinical condition worsened; acute respiratory distress syndrome and massive pulmonary haemorrhage developed. After Stenotrophomonas maltophilia was isolated in blood cultures, the cases were treated successfully using a combination of trimethoprim/sulfamethoxazole and fluoroquinolone.
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    Influence of Intensive Care Unit Enlightenment on Premature Infants on Functional Brain Maturation Assessed by Amplitude-Integrated Electroencephalograph
    (Thieme Medical Publ Inc, 2021) Tandircioglu, Umit Ayse; Guzoglu, Nilufer; Gucuyener, Kivilcim; Aliefendioglu, Didem
    Objective Amplitude-integrated electroencephalograph (aEEG) presents a valuable tool for functional brain maturation of preterm infants. However, the effect of enlightenment on functional brain maturation of premature infants has not been investigated. We aimed to do this with aEEG. Study Design A total of 32 infants, 30 to 35 gestational weeks, were involved in the study. They were randomly distributed into three groups in which different lighting protocols were applied. In group 1, the infants' incubators were covered for 24 hours. In group 2, the infants' incubators were open for 24 hours. In group 3, the infants' incubators were covered for 12 hours and open for another 12 hours. The infants are evaluated with aEEG recordings done on the 3rd (first measurement) and 10th days (second measurement) along with the Burdjalov scoring. Analysis of aEEG recordings was performed, based on sleep-wake cycles (SWCs), upper and lower margin amplitudes, narrowband and broadband of SWC, and bandwidth of SWC. Results At first, the narrowband lower amplitudes in group 1 were higher than those of the other groups (p = 0.042), but the difference was not significant in the second measurement (p = 0.110). The Burdjalov scores were higher in group 1 and group 3 on 10th day, though not statistically significant (p = 0.871). When the infants were reevaluated according to the gestational weeks, the Burdjalov scores of the two groups less than 34 weeks (30-31 and 32-33 weeks) were similar, whereas 34 to 35 weeks were higher when compared with those of the two groups. Conclusion The difference observed between groups in terms of narrowband lower amplitude in the first measurement may reflect the effect of intrauterine environment rather than enlightenment at the same gestational age because it was made on the third day. However, the fact that all groups have similar results on day 10 suggests that other factors in the intensive care setting may diminish the effect of enlightenment. Burdjalov scores are associated with maturation, and high scores found in the 34- to 35-week group suggest that the 34-week maturation might be a threshold for SWC and development in our group sample.
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    Management of hyperbilirubinemia in preterm infants in Turkey
    (Tubitak Scientific & Technical Research Council Turkey, 2016) Guzoglu, Nilufer; Tandircioglu, Umit Ayse; Aliefendioglu, Didem
    Background/aim: Prematurity is a significant risk factor for developing unconjugated hyperbilirubinemia. This study investigated the current approach to managing hyperbilirubinemia in preterm newborns in Turkey. Materials and methods: A study-specific questionnaire on the management of jaundice in preterm infants was sent to 100 level III neonatal intensive care units in Turkey. Results: Responses were obtained from 84 centers from all regions of Turkey. Of the centers, 75.3% used the Turkish Neonatology Society guidelines for deciding to start phototherapy, and 24.7% used different guidelines. The monitoring of bilirubin varied among the participants. Of the participants, 53.6% believed that prophylactic phototherapy was necessary if the infant's birth weight was below 1000 g. The participants reported 6 cases of kernicterus in preterm infants in recent years. Conclusion: There is no single standard approach for managing neonatal hyperbilirubinemia in preterm infants in Turkey. Prophylactic phototherapy for extremely low birth-weight infants might be added to the guidelines for Turkey.
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    Rupture and displacement of umbilical arterial catheter: Bilateral arterial occlusion in a very low birth weight preterm
    (Soc Argentina Pediatria, 2015) Dilli, Dilek; Ozyazici, Elif; Fettah, Nurdan; Kaya, Ozkan; Akdogan, Melek Pala; Zenciroglu, Aysegul; Guzoglu, Nilufer
    Umbilical vessel catheterization is a common procedure in Neonatal Intensive Care Units, especially in very low birthweight infants. Rarely, umbilical artery catheters break, and the retained fragments can cause thrombosis, infection, distal embolization, and even death. Herein, we describe a neonate with clinically significant bilateral limb ischemia developing after removal of a broken umbilical artery catheter. He was under vasodilator treatment in addition to fibrinolytic and anticoagulants. The evolution was favourable.
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    THE EFFECT OF PHOTOTHERAPY TREATMENT ON OXIDATIVE STRESS AND INFLAMMATORY RESPONSE IN NEWBORNS
    (2023) Agirtas, Gulsah; Guzoglu, Nilufer; Akbas, Ozgul Tunc; Kısa, Üçler; Aliefendioglu, Didem
    Objective: A reason for oxidative stress is photodynamic reactions with phototherapy. It is thought that phototherapy changes cytokine production which leads to different effects on the immune system. The aim of this study is to investigate the effects of light-emitting diode (LED) phototherapy and conventional phototherapy on oxidative stress and inflammatory response in neonatal hyperbilirubinemia. Material and Methods: Thirty-term newborns treated with phototherapy were enrolled on the study group. The study group was divided into LED phototherapy (n=15) and conventional phototherapy (n=15) subgroups. The control group consisted of 30-term healthy newborns. Blood samples were taken before phototherapy, at the 24th hours of phototherapy and after phototherapy treatment. Bilirubin, malonaldehyde (MDA), total oxidative stress (TOS), total antioxidant capacity (TAC), TNF- ?, IL-6 and IL-8 levels were evaluated between groups. Results: There were no significant differences in MDA and TAC in the conventional phototherapy group both before and after phototherapy. However, TOS levels were significantly higher during and after phototherapy than before phototherapy in the conventional phototherapy group. In the same group, IL-8 levels were significantly higher during phototherapy than after phototherapy levels. Whereas, there were no significant differences in oxidative stress and inflammatory response parameters in the LED phototherapy group. Conclusion: While conventional phototherapy increases oxidative stress and acts at some stages of the inflammatory response, there are no effects of LED phototherapy on antioxidant defence systems and inflammatory response.